Articles

Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results

Correct staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial re...

Authors: Lisa C. Adams, Keno K. Bressem, Phillipp Jurmeister, Ute L. Fahlenkamp, Bernhard Ralla, Guenther Engel, Bernd Hamm, Jonas Busch and Marcus R. Makowski

CT imaging-based histogram features for prediction of EGFR mutation status of bone metastases in patients with primary lung adenocarcinoma

To identify imaging markers that reflect the epidermal growth factor receptor (EGFR) mutation status by comparing computed tomography (CT) imaging-based histogram features between bone metastases with and with...

Authors: Tong-xu Shen, Lin Liu, Wen-hui Li, Ping Fu, Kai Xu, Yu-qing Jiang, Feng Pan, Yan Guo and Meng-chao Zhang

Primary hepatic perivascular epithelioid cell tumors: imaging findings with histopathological correlation

Hepatic PEComas are very rare. Few systematic reports are available characterizing the imaging and pathological features of hepatic PEComa. The aim of this study was to investigate the imaging findings of prim...

Authors: Pei Nie, Jie Wu, Hexiang Wang, Ruizhi Zhou, Lingling Sun, Jingjing Chen and Guangjie Yang

Chemosaturation with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience

To investigate the outcome and safety data of chemosaturation with percutaneous hepatic perfusion (CS-PHP) of melphalan in patients with liver-dominant metastatic uveal melanoma.

Authors: Christoph Artzner, Oliver Mossakowski, Gerald Hefferman, Ulrich Grosse, Rüdiger Hoffmann, Andrea Forschner, Thomas Eigentler, Roland Syha and Gerd Grözinger

Comparison of diffusion kurtosis imaging versus diffusion weighted imaging in predicting the recurrence of early stage single nodules of hepatocellular carcinoma treated by radiofrequency ablation

This study aimed to compare the diffusion kurtosis imaging (DKI) versus diffusion weighted imaging (DWI) in predicting the recurrence of early stage single nodules of hepatocellular carcinoma (HCC) treated by ...

Authors: Zhen-Guo Yuan, Zong-Ying Wang, Meng-Ying Xia, Feng-Zhi Li, Yao Li, Zhen Shen and Xi-Zhen Wang

Prediction of hepatocellular carcinoma response to ⁹⁰Yttrium radioembolization using volumetric ADC histogram quantification: preliminary results

To assess the predictive value of volumetric apparent diffusion coefficient (vADC) histogram quantification obtained before and 6 weeks (6w) post-treatment for assessment of hepatocellular carcinoma (HCC) resp...

Authors: Sonja Gordic, Mathilde Wagner, Riccardo Zanato, Stefanie Hectors, Cecilia Besa, Shingo Kihira, Edward Kim and Bachir Taouli

The role of ¹⁸F-FDG-PET/CT in evaluating retroperitoneal masses -Keeping your eye on the ball!

Testicular germ cell tumour is the commonest malignancy affecting males aged between 15 and 35, with an increased relative risk amongst those with a history of cryptorchidism. In patients presenting with locor...

Authors: Te-Jui Hung, Luke McLean, Catherine Mitchell, Claire Pascoe, Nathan Lawrentschuk, Declan G. Murphy, Amir Iravani, Dalveer Singh, Michael S. Hofman, Lamiaa Zidan, Tim Akhurst, Jeremy Lewin and Rodney J. Hicks

Behavior of FDG-avid supradiaphragmatic lymph nodes in PET/CT throughout primary therapy in advanced serous epithelial ovarian cancer: a prospective study

Epithelial ovarian cancer (EOC) typically spreads intra-abdominally, but preoperative evaluation with FDG PET/CT often reveals metabolically active supradiaphragmatic lymph nodes (sdLNs). Their clinical signif...

Authors: Maren Laasik, Jukka Kemppainen, Annika Auranen, Sakari Hietanen, Seija Grénman, Marko Seppänen and Johanna Hynninen

Optimizing prostate cancer accumulating model: combined PI-RADS v2 with prostate specific antigen and its derivative data

To establish a new accumulating model to enhance the accuracy of prostate cancer (PCa) diagnosis by incorporating prostate-specific antigen (PSA) and its derivative data into the Prostate Imaging-Reporting and...

Authors: Yuan-Fei Lu, Qian Zhang, Wei-Gen Yao, Hai-Yan Chen, Jie-Yu Chen, Cong-Cong Xu and Ri-Sheng Yu

Quantitative computed tomography texture analysis: can it improve diagnostic accuracy to differentiate malignant lymph nodes?

Mediastinal lymph node (LN) staging in individuals with non-small-cell lung cancer plays an important role in staging and treatment planning. This study aimed to assess the accuracy of computed tomography (CT)...

Authors: So Youn Shin, Il Ki Hong and Yong Suk Jo

Diagnostic value of multislice spiral computed tomography (CT) combined with CT angiography for intra-abdominal undescended testis secondary seminomas

To discuss the diagnostic value of multislice spiral tomography (CT) combined with CT angiography (CTA) technology in intra-abdominal undescended testis secondary seminoma cases.

Authors: Si-qi Wang, Fang-yuan Ren, Jian-hua Wang, Zhi-hao Ren, Zhong-gao Jin, Yu Xu, Zhen-hui Li, Qian-jiang Ding and Chao Zhong

Intra-individual comparison of ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL normal-organ biodistribution

Detailed data comparing the biodistribution of PSMA radioligands is still scarce, raising concerns regarding the comparability of different compounds. We investigated differences in normal-organ biodistributio...

Authors: Gonçalo Ferreira, Amir Iravani, Michael S. Hofman and Rodney J. Hicks

Hepatocellular carcinoma: radiomics nomogram on gadoxetic acid-enhanced MR imaging for early postoperative recurrence prediction

This study was performed to prospectively develop and validate a radiomics nomogram for predicting postoperative early recurrence (≤1 year) of hepatocellular carcinoma (HCC) using whole-lesion radiomics featur...

Authors: Zhen Zhang, Hanyu Jiang, Jie Chen, Yi Wei, Likun Cao, Zheng Ye, Xin Li, Ling Ma and Bin Song

Prediction early recurrence of hepatocellular carcinoma eligible for curative ablation using a Radiomics nomogram

Predicting early recurrence (ER) after radical therapy for HCC patients is critical for the decision of subsequent follow-up and treatment. Radiomic features derived from the medical imaging show great potenti...

Authors: Chunwang Yuan, Zhenchang Wang, Dongsheng Gu, Jie Tian, Peng Zhao, Jingwei Wei, Xiaozhen Yang, Xiaohan Hao, Di Dong, Ning He, Yu Sun, Wenfeng Gao and Jiliang Feng

Investigating the diagnostic value of quantitative parameters based on T2-weighted and contrast-enhanced MRI with psoas muscle and outer myometrium as internal references for differentiating uterine sarcomas from leiomyomas at 3T MRI

Post-hysterectomy histopathological examination is currently the main diagnostic tool for differentiating uterine sarcomas from leiomyomas. This study aimed to investigate the diagnostic accuracy of preoperati...

Authors: Mahrooz Malek, Maryam Rahmani, Seyyedeh Mahdieh Seyyed Ebrahimi, Elnaz Tabibian, Azadeh Alidoosti, Pariya Rahimifar, Setareh Akhavan and Ziba Gandomkar

Application of a machine learning method to whole brain white matter injury after radiotherapy for nasopharyngeal carcinoma

The purpose/aim of this study was to 1) use magnetic resonance diffusion tensor imaging (DTI), fibre bundle/tract-based spatial statistics (TBSS) and machine learning methods to study changes in the white matt...

Authors: Xi Leng, Peng Fang, Huan Lin, Chunhong Qin, Xin Tan, Yi Liang, Chi Zhang, Hongzhuo Wang, Jie An, Donglin Wu, Qihui Liu and Shijun Qiu

Metabolic tumor burden on postsurgical PET/CT predicts survival of patients with gastric cancer

The prognostic value of postoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with gastric cancer remains unclear. This study aims to investigate the...

Authors: Gaofeng Sun, Chao Cheng, Xiao Li, Tao Wang, Jian Yang and Danni Li

Choroid plexus tumours on MRI: similarities and distinctions in different grades

The therapeutic planning varies for different grades of choroid plexus tumours (CPTs). The aim of this study was to define the similarities and distinctions among MRIs for different grades of CPTs, providing m...

Authors: Huan Lin, Xi Leng, Chun-hong Qin, Yong-xing Du, Wen-sheng Wang and Shi-jun Qiu

Ultrasound-guided percutaneous laser ablation for papillary thyroid microcarcinoma: a retrospective analysis of 37 patients

Over the past ten years, more papillary thyroid microcarcinoma (PTMC) has been diagnosed more frequently due to the development of imaging technology, and the incidence of PTMC has increased significantly. Ult...

Authors: Lili Ji, Qin Wu, Jun Gu, Xuedong Deng, Wei Zhou, Xing Fan and Feng Zhou

Evaluation of percutaneous unilateral trans-femoral implantation of side-hole port-catheter system with coil only fixed-catheter-tip for hepatic arterial infusion chemotherapy

The technique for arterial infusion chemotherapy (HAIC) is not standardized which limits its widely application. The aim of this study was to evaluate the long-term functionality and complications of port-cath...

Authors: Jungang Hu, Xu Zhu, Xiaodong Wang, Guang Cao, Xiao Wang and Renjie Yang

Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors

To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibil...

Authors: Ararat Chakhoyan, Catalina Raymond, Jason Chen, Jodi Goldman, Jingwen Yao, Tania B. Kaprealian, Nader Pouratian and Benjamin M. Ellingson

Asymptomatic versus symptomatic solid pseudopapillary tumors of the pancreas: clinical and MDCT manifestations

To delineate the features of multi-detector computed tomography (MDCT) images and clinical characteristics of pancreatic solid pseudopapillary tumors (SPTs) of the pancreas in asymptomatic patients and compare...

Authors: Shudong Hu, Heng Zhang, Xian Wang, Zongqiong Sun, Yuxi Ge, Gen Yan, Changyong Zhao and Kemin Chen

RETRACTED ARTICLE: Ultrasound Elastography supplement assessing nodal status of magnetic resonance imaging staged cervical N0 patients with nasopharyngeal carcinoma

To determine whether ultrasound elastography can distinguish reactive or metastatic small lymph nodes (sLN) of magnetic resonance imaging (MRI) staged cervical N0 patients with nasopharyngeal carcinoma (NPC).

Authors: Jian Li, Fei Han, Yunxian Mo, Xindan Chen, Yong Li and Feifei Zuo

CT-based peritumoral radiomics signatures to predict early recurrence in hepatocellular carcinoma after curative tumor resection or ablation

To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative trea...

Authors: Quan-yuan Shan, Hang-tong Hu, Shi-ting Feng, Zhen-peng Peng, Shu-ling Chen, Qian Zhou, Xin Li, Xiao-yan Xie, Ming-de Lu, Wei Wang and Ming Kuang

Dynamic contrast-enhanced MRI of malignant pleural mesothelioma: a comparative study of pharmacokinetic models and correlation with mRECIST criteria

Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvas...

Authors: Martina Vivoda Tomšič, Sotirios Bisdas, Viljem Kovač, Igor Serša and Katarina Šurlan Popovič

Comparative analysis of the value of diffusion kurtosis imaging and diffusion-weighted imaging in evaluating the histological features of endometrial cancer

This study evaluated and compared the performances of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) for diagnosing and histologically grading endometrial cancer.

Authors: Wei Yue, Nan Meng, Jing Wang, Wenling Liu, Xuejia Wang, Minghuan Yan, Dongming Han and Jingliang Cheng

Application of magnetic resonance diffusion kurtosis imaging for distinguishing histopathologic subtypes and grades of rectal carcinoma

To evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) for distinguishing different histopathological subtypes and grades of rectal carcinoma and to compare DKI with conventional diffusion-...

Authors: Ziqiang Wen, Yan Chen, Xinyue Yang, Baolan Lu, Yiyan Liu, Bingqi Shen and Shenping Yu

2020 vision or myopia? A personal perspective on the future of cancer imaging and an introduction to the sequels to the “How I Read Series”

Authors: Rodney J. Hicks

CT texture analysis: a potential tool for predicting the Fuhrman grade of clear-cell renal carcinoma

The purpose of this study was to analyze the image heterogeneity of clear-cell renal-cell carcinoma (ccRCC) by computer tomography texture analysis and to provide new objective quantitative imaging parameters ...

Authors: Zhan Feng, Qijun Shen, Ying Li and Zhengyu Hu

The utility of MRI histogram and texture analysis for the prediction of histological diagnosis in head and neck malignancies

To assess the utility of histogram and texture analysis of magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for the prediction of histological diagnosis of head and neck squamous cell carci...

Authors: Noriyuki Fujima, Akihiro Homma, Taisuke Harada, Yukie Shimizu, Khin Khin Tha, Satoshi Kano, Takatsugu Mizumachi, Ruijiang Li, Kohsuke Kudo and Hiroki Shirato

Prediction of high nodal burden with ultrasound and magnetic resonance imaging in clinically node-negative breast cancer patients

Although the role of axillary imaging has been redirected for predicting high nodal burden rather than predicting nodal metastases since ACOSOG Z1011 trial, it remains unclear whether and how axillary lymph no...

Authors: Won Hwa Kim, Hye Jung Kim, So Mi Lee, Seung Hyun Cho, Kyung Min Shin, Sang Yub Lee and Jae Kwang Lim

Computed tomographic features of adenoid cystic carcinoma in the palate

To evaluate the computed tomographic features and create a prediction model for clinical diagnosis of adenoid cystic carcinoma (ACC) in the palate with intact mucosa.

Authors: Wu-tong Ju, Tong-chao Zhao, Ying Liu, Yi-ran Tan, Min-jun Dong, Qi Sun, Li-zhen Wang, Jiang Li and Lai-ping Zhong

Distribution of metastasis in the brain in relation to the hippocampus: a retrospective single-center analysis of 565 metastases in 116 patients

To examine the distribution of brain metastases (BM) in relation to the hippocampus, so as to determine the risk of metastasis in the hippocampus, and thus provide experimental evidence for the hippocampal avo...

Authors: Qian Sun, Min Li, Gengming Wang, Hongbo Xu, Zelai He, Yongchun Zhou, Yan Zhou, Yufu Zhou, Hongwei Song and Hao Jiang

Whole-body diffusion-weighted MRI for operability assessment in patients with colorectal cancer and peritoneal metastases

Correct staging of patients with colorectal cancer is of utmost importance for the prediction of operability. Although computed tomography (CT) has a good overall performance, estimation of peritoneal cancer s...

Authors: Raphaëla Carmen Dresen, Sofie De Vuysere, Frederik De Keyzer, Eric Van Cutsem, Hans Prenen, Ragna Vanslembrouck, Gert De Hertogh, Albert Wolthuis, André D’Hoore and Vincent Vandecaveye

“Sentinel lymph node imaging with sequential SPECT/CT lymphoscintigraphy before and after neoadjuvant chemoradiotherapy in patients with cancer of the oesophagus or gastro-oesophageal junction – a pilot study”

In current best practise, curatively intended treatment for oesophageal cancer usually consists of neoadjuvant chemo-radiotherapy (nCRT) or perioperative chemotherapy, and oesophagectomy. Sentinel Lymph Node B...

Authors: Stefan Gabrielson, Jon A. Tsai, Fuat Celebioglu, Magnus Nilsson, Ioannis Rouvelas, Mats Lindblad, Annie Bjäreback, Artur Tomson and Rimma Axelsson

CT texture analysis of lung adenocarcinoma: can Radiomic features be surrogate biomarkers for EGFR mutation statuses

To investigate whether radiomic features can be surrogate biomarkers for epidermal growth factor receptor (EGFR) mutation statuses.

Authors: Dongdong Mei, Yan Luo, Yan Wang and Jingshan Gong

IDEAL-IQ in an oncologic population: meeting the challenge of concomitant liver fat and liver iron

Cancer patients often have a history of chemotherapy, putting them at increased risk of liver toxicity and pancytopenia, leading to elevated liver fat and elevated liver iron respectively. T1-in-and-out-of-pha...

Authors: Sarah Eskreis-Winkler, Giuseppe Corrias, Serena Monti, Junting Zheng, Marinela Capanu, Simone Krebs, Maggie Fung, Scott Reeder and Lorenzo Mannelli

Discrepancies of assessments in a RECIST 1.1 phase II clinical trial – association between adjudication rate and variability in images and tumors selection

In imaging-based clinical trials, it is common practice to perform double reads for each image, discrepant interpretations can result from these two different evaluations. In this study we analyzed discrepanci...

Authors: Hubert Beaumont, Tracey L. Evans, Catherine Klifa, Ali Guermazi, Sae Rom Hong, Mustapha Chadjaa and Zsuzsanna Monostori

Preoperative prediction of peripancreatic vein invasion by pancreatic head cancer

Pancreatic adenocarcinoma is often diagnosed at an advanced stage when adjacent vascular invasion is present. Accurate evaluation of presence of vascular invasion can help guide therapy. The aim of this study ...

Authors: Yi-Nan Shen, Cheng-Xiang Guo, Yao Pan, Yi-Wen Chen, Tian-Yu Tang, Yu-Wei Li, Jun-Hua Lu, Gang Jin, Ren-Yi Qin, Wei-Yun Yao, Ting-Bo Liang and Xue-Li Bai

Comparison of gadoxetic acid versus gadopentetate dimeglumine for the detection of hepatocellular carcinoma at 1.5 T using the liver imaging reporting and data system (LI-RADS v.2017)

The goal of this study was to investigate the Liver Imaging Reporting and Data System (LI-RADS) v.2017 for the categorization of hepatocellular carcinomas (HCCs) with gadoxetic acid compared with gadopentetate...

Authors: Ying Ding, Sheng-xiang Rao, Wen-tao Wang, Cai-zhong Chen, Ren-chen Li and Mengsu Zeng

The eye of the beholder: orbital metastases from midgut neuroendocrine tumors, a two institution experience

Metastases to the orbit occur rarely in midgut neuroendocrine tumor (NET) patients with only 20 cases reported to date. Patients typically present with bilateral involvement of the recti muscles and experience...

Authors: Satya Das, Gino Pineda, Laura Goff, Rachel Sobel, Jordan Berlin and George Fisher

Tumor heterogeneity in gastrointestinal stromal tumors of the small bowel: volumetric CT texture analysis as a potential biomarker for risk stratification

To explore whether volumetric CT texture analysis (CTTA) can serve as a potential imaging biomarker for risk stratification of small bowel gastrointestinal stromal tumors (small bowel-GISTs).

Authors: Cui Feng, Fangfang Lu, Yaqi Shen, Anqin Li, Hao Yu, Hao Tang, Zhen Li and Daoyu Hu

Endometrial cancer: an overview of novelties in treatment and related imaging keypoints for local staging

Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based on surgery. Pre-operative imaging is...

Authors: Stefania Rizzo, Marco Femia, Valentina Buscarino, Dorella Franchi, Annalisa Garbi, Vanna Zanagnolo, Maria Del Grande, Lucia Manganaro, Sarah Alessi, Caterina Giannitto, Francesca Ruju and Massimo Bellomi

Mono, bi- and tri-exponential diffusion MRI modelling for renal solid masses and comparison with histopathological findings

To compare diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM), and tri-exponential models of the diffusion magnetic resonance imaging (MRI) signal for the characterization of renal lesions in ...

Authors: Sophie van Baalen, Martijn Froeling, Marino Asselman, Caroline Klazen, Claire Jeltes, Lotte van Dijk, Bart Vroling, Pieter Dik and Bennie ten Haken

Diffusion-weighted imaging of rectal cancer on repeatability and cancer characterization: an effect of b-value distribution study

To explore the effect of b-value distributions on the repeatability and diagnostic performance of the ADC value in rectal cancer patients using multiple b-values and mono-exponential model diffusion-weighted i...

Authors: Luguang Chen, Fu Shen, Zhihui Li, Haidi Lu, Yukun Chen, Zhen Wang and Jianping Lu

Detection of gastric cancer and its histological type based on iodine concentration in spectral CT

Computed tomography (CT) imaging is the most common imaging modality for the diagnosis and staging of gastric cancer. The aim of this study is was to prospectively explore the ability of quantitative spectral ...

Authors: Rui Li, Jing Li, Xiaopeng Wang, Pan Liang and Jianbo Gao

Evaluation of pancreatic tumor development in KPC mice using multi-parametric MRI

Pancreatic ductal adenocarcinoma (PDA) is a fatal disease with very poor prognosis. Development of sensitive and noninvasive methods to monitor tumor progression in PDA is a critical and unmet need. Magnetic r...

Authors: Ravneet Vohra, Joshua Park, Yak-Nam Wang, Kayla Gravelle, Stella Whang, Joo-Ha Hwang and Donghoon Lee

Pain control for patients with hepatocellular carcinoma undergoing CT-guided percutaneous microwave ablation

Hepatic percutaneous microwave ablation (MWA) is usually performed in patients under conscious sedation. Nonetheless, many patients reported pain during the procedure. The current study investigated the safety...

Authors: Hong-Zhi Zhang, Jie Pan, Jing Sun, Yu-Mei Li, Kang Zhou, Yang Li, Jin Cheng, Ying Wang, Dong-Lei Shi and Shao-Hui Chen

68Ga-PSMA PET/CT in prostate cancer patients – patterns of disease, benign findings and pitfalls

68Ga-PSMA PET/CT has an important role in assessment of prostate cancer patients with biochemical recurrence and is evolving in staging high- and intermediate risk disease. The aim of present study was to desc...

Authors: Zohar Keidar, Ronit Gill, Elinor Goshen, Ora Israel, Tima Davidson, Maryna Morgulis, Natalia Pirmisashvili and Simona Ben-Haim

Diffusion-weighted MR imaging of locally advanced breast carcinoma: the optimal time window of predicting the early response to neoadjuvant chemotherapy

It is very difficult to predict the early response to NAC only on the basis of change in tumor size. ADC value derived from DWI promises to be a valuable parameter for evaluating the early response to treatmen...

Authors: Li Yuan, Jian-Jun Li, Chang-Qing Li, Cheng-Gong Yan, Ze-Long Cheng, Yuan-Kui Wu, Peng Hao, Bing-Quan Lin and Yi-Kai Xu