Articles

Role of whole-body MRI for treatment response assessment in multiple myeloma: comparison between clinical response and imaging response

Whole-body MRI (WB-MRI) including diffusion-weighted image (DWI) have been widely used in patients with multiple myeloma. However, evidence for the value of WB-MRI in the evaluation of treatment response remai...

Authors: Ho Young Park, Kyung Won Kim, Min A. Yoon, Min Hee Lee, Eun Jin Chae, Jeong Hyun Lee, Hye Won Chung and Dok Hyun Yoon

Contrast-enhanced CT radiomics for predicting lymph node metastasis in pancreatic ductal adenocarcinoma: a pilot study

We developed a computational model integrating clinical data and imaging features extracted from contrast-enhanced computed tomography (CECT) images, to predict lymph node (LN) metastasis in patients with panc...

Authors: Ke Li, Qiandong Yao, Jingjing Xiao, Meng Li, Jiali Yang, Wenjing Hou, Mingshan Du, Kang Chen, Yuan Qu, Lian Li, Jing Li, Xianqi Wang, Haoran Luo, Jia Yang, Zhuoli Zhang and Wei Chen

Early metabolic response of breast cancer to neoadjuvant endocrine therapy: comparison to morphological and pathological response

Neoadjuvant endocrine therapy (NET) has shown efficacy in terms of clinical response and surgical outcome in postmenopausal patients with estrogen receptor-positive / HER2-negative breast cancer (ER+/HER2- BC)...

Authors: Sarah Boughdad, Laurence Champion, Veronique Becette, Pascal Cherel, Emmanuelle Fourme, Jerome Lemonnier, Florence Lerebours and Jean-Louis Alberini

PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review

PSMA PET is a promising method for primary lymph node staging in prostate cancer. However, recent systematic reviews have identified only a limited number of studies with histopathology as a reference test.

Authors: Lars J. Petersen and Helle D. Zacho

Intravoxel incoherent motion and ADC measurements for differentiating benign from malignant thyroid nodules: utilizing the most repeatable region of interest delineation at 3.0 T

There is a growing need for a reproducible and effective imaging method for the quantitative differentiation of benign from malignant thyroid nodules. This study aimed to investigate the performances of intrav...

Authors: Minghui Song, Yunlong Yue, Yanfang Jin, Jinsong Guo, Lili Zuo, Hong Peng and Queenie Chan

The value of DWI in predicting the response to synchronous radiochemotherapy for advanced cervical carcinoma: comparison among three mathematical models

Diffusion weighted imaging(DWI) mode mainly includes intravoxel incoherent motion (IVIM), stretched exponential model (SEM) and Gaussian diffusion model, but it is still unclear which mode is the most valuable in...

Authors: Hui Zhang, Yuyang Zhou, Jie Li, Pengjuan Zhang, Zhenzhen Li and Junwu Guo

A Delta-radiomics model for preoperative evaluation of Neoadjuvant chemotherapy response in high-grade osteosarcoma

The difficulty of assessment of neoadjuvant chemotherapeutic response preoperatively may hinder personalized-medicine strategies that depend on the results from pathological examination.

Authors: Peng Lin, Peng-Fei Yang, Shi Chen, You-You Shao, Lei Xu, Yan Wu, Wangsiyuan Teng, Xing-Zhi Zhou, Bing-Hao Li, Chen Luo, Lei-Ming Xu, Mi Huang, Tian-Ye Niu and Zhao-Ming Ye

Quantification of tumor burden in multiple myeloma by atlas-based semi-automatic segmentation of WB-DWI

Whole-body diffusion weighted imaging (WB-DWI) has proven value to detect multiple myeloma (MM) lesions. However, the large volume of imaging data and the presence of numerous lesions makes the reading process...

Authors: Sílvia D. Almeida, João Santinha, Francisco P. M. Oliveira, Joana Ip, Maria Lisitskaya, João Lourenço, Aycan Uysal, Celso Matos, Cristina João and Nikolaos Papanikolaou

Development and validation of a nomogram based on CT images and 3D texture analysis for preoperative prediction of the malignant potential in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs), which are the most common mesenchymal tumors of the digestive system, are treated varyingly according to the malignancy. The purpose of this study is to develop and val...

Authors: Caiyue Ren, Shengping Wang and Shengjian Zhang

¹⁸F-FDG PET/CT imaging findings in anaplastic large cell lymphoma, a rare subtype of lymphoma

To investigate the ¹⁸F-FDG PET/CT imaging manifestations for anaplastic large cell lymphoma (ALCL), a rare subtype of T/NK cell lymphoma.

Authors: Yanping Jiang, Lijuan Wang, Wenlan Zhou, Jiamei Gu, Ying Tian, Ye Dong, Lilan Fu and Hu-bing Wu

Utility of diffusion weighted imaging with the quantitative apparent diffusion coefficient in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization: a meta-analysis

Accurate and early diagnosis of residual tumors or intrahepatic recurrences after TACE is critically needed for determining the success of treatments and for guiding subsequent therapeutic planning. This meta-...

Authors: Zhao Liu, Jin-Ming Fan, Chen He, Zhi-Fan Li, Yong-Sheng Xu, Zhao Li, Hai-Feng Liu and Jun-Qiang Lei

iRECIST: how to do it

iRECIST for the objective monitoring of immunotherapies was published by the official RECIST working group in 2017.

Authors: Thorsten Persigehl, Simon Lennartz and Lawrence H. Schwartz

Contrast-enhanced ultrasound findings of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma

To investigate the contrast-enhanced ultrasound (CEUS) findings of renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene fusion (Xp11.2/TFE3) in adult patients by comparison with those of c...

Authors: Shuping Wei, Fuli Tian, Qiuyuan Xia, Pengfei Huang, Yidan Zhang, Zhichao Xia, Min Wu and Bin Yang

Superb microvascular imaging technique in depicting vascularity in focal liver lesions: more hypervascular supply patterns were depicted in hepatocellular carcinoma

To investigate the capacity of Superb Microvascular Imaging (SMI) to detect microvascular details and to explore the different SMI features in various focal liver lesions (FLLs) and the correlation between SMI...

Authors: Fan Yang, Jing Zhao, Chunwei Liu, Yiran Mao, Jie Mu, Xi Wei, Jinyan Jia, Sheng Zhang, Xiaojie Xin and Jian Tan

Breast MRI and tumour biology predict axillary lymph node response to neoadjuvant chemotherapy for breast cancer

In patients who have had axillary nodal metastasis diagnosed prior to neoadjuvant chemotherapy for breast cancer, there is little consensus on how to manage the axilla subsequently. The aim of this study was t...

Authors: Samia Al-Hattali, Sarah J. Vinnicombe, Nazleen Muhammad Gowdh, Andrew Evans, Sharon Armstrong, Douglas Adamson, Colin A. Purdie and E. Jane Macaskill

Comparison of biparametric and multiparametric MRI in the diagnosis of prostate cancer

To compare the diagnostic accuracy of biparametric MRI (bpMRI) and multiparametric MRI (mpMRI) for prostate cancer (PCa) and clinically significant prostate cancer (csPCa) and to explore the application value ...

Authors: Lili Xu, Gumuyang Zhang, Bing Shi, Yanhan Liu, Tingting Zou, Weigang Yan, Yu Xiao, Huadan Xue, Feng Feng, Jing Lei, Zhengyu Jin and Hao Sun

The effects of volume of interest delineation on MRI-based radiomics analysis: evaluation with two disease groups

Manual delineation of volume of interest (VOI) is widely used in current radiomics analysis, suffering from high variability. The tolerance of delineation differences and possible influence on each step of rad...

Authors: Xiao Zhang, Liming Zhong, Bin Zhang, Lu Zhang, Haiyan Du, Lijun Lu, Shuixing Zhang, Wei Yang and Qianjin Feng

Ultra-early changes in vascular parameters from dynamic contrast enhanced MRI of breast cancer xenografts following systemic therapy with doxorubicin and liver X receptor agonist

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) may be used to depict tumour vascular structure and for therapy response assessment in various tumour sites. The purpose of the current work is to...

Authors: Kathinka E. Pitman, Kine M. Bakke, Alexandr Kristian and Eirik Malinen

Use of percutaneous microwave ablation for the treatment of bone tumors: a retrospective study of clinical outcomes in 47 patients

The present study aimed to evaluate the short-term clinical performance and safety of percutaneous microwave ablation (MWA) techniques for the treatment of bone tumors.

Authors: Min-hao Wu, Ling-fei Xiao, Fei-fei Yan, Shi-Liang Chen, Chong Zhang, Jun Lei and Zhou-ming Deng

High negative predictive value of 68Ga PSMA PET-CT for local lymph node metastases in high risk primary prostate cancer with histopathological correlation

Current guidelines highlight the importance of accurate staging in the management and prognostication of high risk primary prostate cancer. Conventional radiologic imaging techniques are insufficient to reliab...

Authors: Labib Ataur Rahman, Damacent Rutagengwa, Peter Lin, Michael Lin, June Yap, Ken Lai, Pascal Mancuso, Prem Rathore, Kayvan Haghighi, Paul Gassner, Lee Hao Wong and Nestor Lalak

RECIST and CHOI criteria in the evaluation of tumor response in patients with metastatic colorectal cancer treated with regorafenib, a prospective multicenter study

To evaluate the objective response rate (ORR) at 2 months of treatment with regorafenib according to RECIST 1.1, Choi, and modified Choi (mChoi) criteria in patients with metastatic colorectal cancer (mCRC).

Authors: Olivier Lucidarme, Mathilde Wagner, Paul Gillard, Stefano Kim, Jean-Baptiste Bachet, Benoit Rousseau, Thibault Mazard, Christophe Louvet, Benoist Chibaudel, Romain Cohen, Marie-Line Garcia-Larnicol, Aurelien Gobert, Julie Henriques and Thierry André

Man or machine? Prospective comparison of the version 2018 EASL, LI-RADS criteria and a radiomics model to diagnose hepatocellular carcinoma

The Liver Imaging Reporting and Data System (LI-RADS) and European Association for the Study of the Liver (EASL) criteria are widely used for diagnosing hepatocellular carcinoma (HCC). Radiomics allows further...

Authors: Hanyu Jiang, Xijiao Liu, Jie Chen, Yi Wei, Jeong Min Lee, Likun Cao, Yuanan Wu, Ting Duan, Xin Li, Ling Ma and Bin Song

Diagnostic performance in T staging for patients with esophagogastric junction cancer using high-resolution MRI: a comparison with conventional MRI at 3 tesla

To investigate and compare the diagnostic performance in T staging for patients with esophagogastric junction cancer using high-resolution magnetic resonance imaging (HR MRI), as compared with conventional MRI...

Authors: Yuan Yuan, Luguang Chen, Shengnan Ren, Zhen Wang, Yukun Chen, Aiguo Jin, Shuai Li, Xu Fang, Tiegong Wang, Yun Bian, Qingsong Yang, Chenguang Bai, Qiang Hao and Jianping Lu

CT-assessed sarcopenia is a predictive factor for both long-term and short-term outcomes in gastrointestinal oncology patients: a systematic review and meta-analysis

The impact of sarcopenia on the outcome of gastrointestinal (GI) oncological patients is still controversial. We aim to discuss the prevalence of sarcopenia and its relation to the oncological outcome.

Authors: Huaiying Su, Junxian Ruan, Tianfeng Chen, Enyi Lin and Lijing Shi

Radiological semantics discriminate clinically significant grade prostate cancer

Identification of imaging traits to discriminate clinically significant prostate cancer is challenging due to the multi focal nature of the disease. The difficulty in obtaining a consensus by the Prostate Imag...

Authors: Qian Li, Hong Lu, Jung Choi, Kenneth Gage, Sebastian Feuerlein, Julio M. Pow-Sang, Robert Gillies and Yoganand Balagurunathan

An exploratory study of CT-guided percutaneous radiofrequency ablation for stage I thymoma

Thymoma is a rare tumor that originates from thymic epithelial cells and is usually associated with myasthenia gravis. Radiofrequency ablation (RFA) is a minimally invasive and curative treatment for other tum...

Authors: Jun Dong, Shaofei Yuan, Boyang Chang, Jinsheng Huang, Xiaojing Geng, Xiuyu Cai, Pili Hu, Bei Zhang, Liangping Xia and Peihong Wu

Contrast-enhanced ultrasound in detecting wall invasion and differentiating bland from tumor thrombus during robot-assisted inferior vena cava thrombectomy for renal cell carcinoma

Vena cava thrombus is one of the main clinical manifestations of locally aggressive renal cell carcinoma (RCC). Inferior vena cava (IVC) wall invasion and presence of bland thrombus could affect the surgical o...

Authors: Qiu-Yang Li, Nan Li, Qing-Bo Huang, Yu-Kun Luo, Bao-Jun Wang, Ai-Tao Guo, Xin Ma, Xu Zhang and Jie Tang

Lesion measurement on a combined “all-in-one” window for chest CT: effect on intra- and interobserver variability

A newly developed image processing technique fuses conventional windows into a single ‘All-In-One’ (AIO) window. This study aims to evaluate variability of CT measurement of lesions in thoracic oncology patien...

Authors: Annemiek Snoeckx, Jeroen Cant, Caro Franck, Elisa Luyckx, Ken Carpentier, Simon Nicolay, Astrid Van Hoyweghen, Maarten J. Spinhoven, Pieter Vuylsteke and Paul M. Parizel

Dual-energy spectral CT characteristics in surgically resected lung adenocarcinoma: comparison between Kirsten rat sarcoma viral oncogene mutations and epidermal growth factor receptor mutations

Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) are the two most frequent and well-known oncogene of lung adenocarcinoma. The purpose of this study is to compare the ...

Authors: Meng Li, Li Zhang, Wei Tang, Jian-Chun Duan, Yu-Jing Jin, Lin-Lin Qi and Ning Wu

Tumor treating fields in the management of Glioblastoma: opportunities for advanced imaging

Alternating electric fields have been successfully applied to cancer cells in-vitro to disrupt malignant progression and this antimitotic therapy has now been proven to be efficacious in Phase II and Phase III...

Authors: Vikram S. Soni and Ted K. Yanagihara

Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response

To evaluate the predictive value of the lipiodol retention pattern for local progression of HCC with a complete response (CR) on CT according to mRECIST criteria after a first session of conventional chemoembo...

Authors: Marco Dioguardi Burgio, Riccardo Sartoris, Claudia Libotean, Magaly Zappa, Annie Sibert, Valérie Vilgrain and Maxime Ronot

Diffusion-weighted imaging for identifying patients at high risk of tumor recurrence following liver transplantation

Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver...

Authors: Yi-Hsuan Chuang, Hsin-You Ou, Chun-Yen Yu, Chao-Long Chen, Ching-Chun Weng, Leo Leung-Chit Tsang, Hsien-Wen Hsu, Wei-Xiong Lim, Tung-Liang Huang and Yu-Fan Cheng

The added diagnostic value of complementary gadoxetic acid-enhanced MRI to ¹⁸F-DOPA-PET/CT for liver staging in medullary thyroid carcinoma

A high proportion of patients with advanced stages of medullary thyroid carcinoma (MTC) present with liver metastasis metastases. The aim of our study was to investigate the added diagnostic value of complemen...

Authors: Daniel Puhr-Westerheide, Clemens C. Cyran, Josef Sargsyan-Bergmann, Andrei Todica, Franz-Josef Gildehaus, Wolfgang G. Kunz, Robert Stahl, Christine Spitzweg, Jens Ricke and Philipp M. Kazmierczak

CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer

The objectives of this retrospective study were to evaluate the usefulness of computed tomography lymphography (CTL) and to clarify the optimal timing of CTL in sentinel lymph node (SLN) mapping of clinically ...

Authors: Satomi Sugiyama, Toshinori Iwai, Toshiharu Izumi, Keita Ishiguro, Junichi Baba, Senri Oguri and Kenji Mitsudo

Local application of doxorubicin- loaded Iron oxid nanoparticles and the vascular disrupting agent via the hepatic artery: chemoembolization–photothermal ablation treatment of hepatocellular carcinoma in rats

This study investigates the effectiveness of local application of doxorubicin(Dox)-loaded, polydopamine (PDA)- coated single crystal hematite (α- Fe₂O₃) nanocubes (Fe₂O₃-PDA-Dox) and combretastatin A-4 phosphate ...

Authors: Hongjun Yuan, Xin Li, Jing Tang, Min Zhou and Fengyong Liu

Non-invasive MR assessment of the microstructure and microcirculation in regional lymph nodes for rectal cancer: a study of intravoxel incoherent motion imaging

The aim of this study is to evaluate the microstructure and microcirculation of regional lymph nodes (LNs) in rectal cancer by using non-invasive intravoxel incoherent motion MRI (IVIM-MRI), and to distinguish...

Authors: Xinyue Yang, Yan Chen, Ziqiang Wen, Yiyan Liu, Xiaojuan Xiao, Wen Liang and Shenping Yu

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biop...

Authors: Min-hao Wu, Ling-fei Xiao, Huo-wen Liu, Zhi-qiang Yang, Xiao-xiao Liang, Yan Chen, Jun Lei and Zhou-ming Deng

Radiogenomic analysis of vascular endothelial growth factor in patients with diffuse gliomas

To predict vascular endothelial growth factor (VEGF) expression in patients with diffuse gliomas using radiomic analysis.

Authors: Zhiyan Sun, Yiming Li, Yinyan Wang, Xing Fan, Kaibin Xu, Kai Wang, Shaowu Li, Zhong Zhang, Tao Jiang and Xing Liu

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Increasing numbers of breast cancer patients receive neoadjuvant chemotherapy (NACT). We seek to investigate whether baseline mammographic and ultrasound features are associated with complete pathological resp...

Authors: Sarah L. Savaridas, Yee Ting Sim, Sarah J. Vinnicombe, Colin A. Purdie, Alastair M. Thompson and Andy Evans

CT radiomic features for predicting resectability of oesophageal squamous cell carcinoma as given by feature analysis: a case control study

Computed tomography (CT) is commonly used in all stages of oesophageal squamous cell carcinoma (SCC) management. Compared to basic CT features, CT radiomic features can objectively obtain more information abou...

Authors: Jing Ou, Rui Li, Rui Zeng, Chang-qiang Wu, Yong Chen, Tian-wu Chen, Xiao-ming Zhang, Lan Wu, Yu Jiang, Jian-qiong Yang, Jin-ming Cao, Sun Tang, Meng-jie Tang and Jiani Hu

Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

MRI-guided laser interstitial thermal therapy (LITT) is the selective ablation of a lesion or a tissue using heat emitted from a laser device. LITT is considered a less invasive technique compared to open surg...

Authors: Usama Salem, Vinodh A. Kumar, John E. Madewell, Donald F. Schomer, Dhiego Chaves de Almeida Bastos, Pascal O. Zinn, Jeffrey S. Weinberg, Ganesh Rao, Sujit S. Prabhu and Rivka R. Colen

Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution

As artificial intelligence methods for the diagnosis of disease advance, we aimed to evaluate machine learning in the predictive task of distinguishing between malignant and benign breast lesions on an indepen...

Authors: Yu Ji, Hui Li, Alexandra V. Edwards, John Papaioannou, Wenjuan Ma, Peifang Liu and Maryellen L. Giger

Utility of diffusion-weighted and contrast-enhanced magnetic resonance imaging in diagnosing and differentiating between high- and low-grade uterine endometrial stromal sarcoma

Endometrial stromal sarcoma (ESS) is a rare uterine malignancy that features different prognoses for its high- and low-grade subtypes. We investigated the diagnostic accuracy of magnetic resonance (MR) imaging...

Authors: Yen-Ling Huang, Shir-Hwa Ueng, Kueian Chen, Yu-Ting Huang, Hsin-Ying Lu, Koon-Kwan Ng, Ting-Chang Chang, Chyong-Huey Lai and Gigin Lin

The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course

Authors:

Early differentiating between the chemotherapy responders and nonresponders: preliminary results with ultrasonic spectrum analysis of the RF time series in preclinical breast cancer models

This study was aimed to assess whether ultrasonic spectrum analysis of radiofrequency (RF) time series using a clinical ultrasound system allows for early differentiating between the chemotherapy responders an...

Authors: Fei Li, Yini Huang, Jianwei Wang, Chunyi Lin, Qing Li, Xueyi Zheng, Yun Wang, Longhui Cao and Jianhua Zhou

Radiomics models for diagnosing microvascular invasion in hepatocellular carcinoma: which model is the best model?

To explore the feasibility of diagnosing microvascular invasion (MVI) with radiomics, to compare the diagnostic performance of different models established by each method, and to determine the best diagnostic ...

Authors: Ming Ni, Xiaoming Zhou, Qian Lv, Zhiming Li, Yuanxiang Gao, Yongqi Tan, Jihua Liu, Fang Liu, Haiyang Yu, Linlin Jiao and Gang Wang

Diffusion-weighted magnetic resonance imaging in bladder cancer: comparison of readout-segmented and single-shot EPI techniques

To evaluate whether readout-segment echo-planar imaging (RS-EPI) can provide better image quality in assessing bladder cancer than single-shot echo-planar imaging (SS-EPI) and to compare quantitative imaging p...

Authors: Haihu Chen, Luguang Chen, Fang Liu, Jianping Lu, Chuanliang Xu and Li Wang

¹⁸F-FDG-PET-based Radiomics signature predicts MGMT promoter methylation status in primary diffuse glioma

The methylation status of the O⁶-methylguanine-DNA methyltransferase (MGMT) promoter has emerged as a favorable independent prognostic and predictive biomarker in glioma. This study aimed to build a radiomics sig...

Authors: Ziren Kong, Yusong Lin, Chendan Jiang, Longfei Li, Zehua Liu, Yuekun Wang, Congxin Dai, Delin Liu, Xuying Qin, Yu Wang, Zhenyu Liu, Xin Cheng, Jie Tian and Wenbin Ma

How we read: the combined use of MRI and novel PET tracers for the characterisation and treatment planning of masses in neuro-oncology

Technical advances in imaging are well demonstrated by MRI (Magnetic Resonance Imaging) and PET (Positron Emission Tomography). Excellent anatomical detail and a lack of ionising radiation make MRI the standar...

Authors: Arian Lasocki and Rodney J. Hicks

Using neighborhood gray tone difference matrix texture features on dual time point PET/CT images to differentiate malignant from benign FDG-avid solitary pulmonary nodules

Lung cancer usually presents as a solitary pulmonary nodule (SPN) on diagnostic imaging during the early stages of the disease. Since the early diagnosis of lung cancer is very important for treatment, the acc...

Authors: Song Chen, Stephanie Harmon, Timothy Perk, Xuena Li, Meijie Chen, Yaming Li and Robert Jeraj