Articles

Using neighborhood gray tone difference matrix texture features on dual time point PET/CT images to differentiate malignant from benign FDG-avid solitary pulmonary nodules

Lung cancer usually presents as a solitary pulmonary nodule (SPN) on diagnostic imaging during the early stages of the disease. Since the early diagnosis of lung cancer is very important for treatment, the acc...

Authors: Song Chen, Stephanie Harmon, Timothy Perk, Xuena Li, Meijie Chen, Yaming Li and Robert Jeraj

Retraction Note to: Ultrasound Elastography supplement assessing nodal status of magnetic resonance imaging staged cervical N0 patients with nasopharyngeal carcinoma

The Editors have retracted this article [1] because figure 2 has been substantially duplicated from a previously published article by Chen B et al., 2018 [2]. There is also significant and uncited overlap in t...

Authors: Jian Li, Fei Han, Yunxian Mo, Xindan Chen, Yong Li and Feifei Zuo

Clinical impact of variability on CT radiomics and suggestions for suitable feature selection: a focus on lung cancer

Radiomics suffers from feature reproducibility. We studied the variability of radiomics features and the relationship of radiomics features with tumor size and shape to determine guidelines for optimal radiomi...

Authors: Seung-Hak Lee, Hwan-ho Cho, Ho Yun Lee and Hyunjin Park

Imaging and clinical features of Castleman Disease

Castleman disease (CD) is a group of uncommon lymphoproliferative disorders that is easily confused with lymphoma or other solid tumors. The purpose of our study was to evaluate the imaging and clinical findin...

Authors: Shuang Zhao, Ying Wan, Zixing Huang, Bin Song and Jianqun Yu

PET/MRI and PET/CT hybrid imaging of rectal cancer – description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study

The role of hybrid imaging using ¹⁸F-fluoro-2-deoxy-D-glucose positron-emission tomography (FDG-PET), computed tomography (CT) and magnetic resonance imaging (MRI) to improve preoperative evaluation of rectal can...

Authors: Miriam K. Rutegård, Malin Båtsman, Jan Axelsson, Patrik Brynolfsson, Fredrik Brännström, Jörgen Rutegård, Ingrid Ljuslinder, Lennart Blomqvist, Richard Palmqvist, Martin Rutegård and Katrine Riklund

Accuracy and complications of CT-guided pulmonary core biopsy in small nodules: a single-center experience

Computed tomography (CT)-guided pulmonary core biopsies of small pulmonary nodules less than 15 millimeters (mm) are challenging for radiologists, and their diagnostic accuracy has been shown to be variable in...

Authors: Ming-De Huang, Hsu-Huei Weng, Sheng-Lung Hsu, Li-Sheng Hsu, Wei-Ming Lin, Chien-Wei Chen and Yuan-Hsiung Tsai

Diagnostic value of spectral reconstructions in detecting incidental skeletal muscle metastases in CT staging examinations

To investigate if iodine density overlay maps (IDO) and virtual monoenergetic images at 40 keV (VMI_40keV) acquired from spectral detector computed tomography (SDCT) can improve detection of incidental skeletal mu...

Authors: Simon Lennartz, Nils Große Hokamp, Nuran Abdullayev, Markus Le Blanc, Andra-Iza Iuga, Grischa Bratke, David Zopfs, David Maintz, Jan Borggrefe and Thorsten Persigehl

Prediction for early recurrence of intrahepatic mass-forming cholangiocarcinoma: quantitative magnetic resonance imaging combined with prognostic immunohistochemical markers

Partial hepatectomy is the first option for intrahepatic mass-forming cholangiocarcinoma (IMCC) treatment, which would prolong survival. The main reason for the poor outcome after curative resection is the hig...

Authors: Li Zhao, Xiaohong Ma, Meng Liang, Dengfeng Li, Peiqing Ma, Sicong Wang, Zhiyuan Wu and Xinming Zhao

Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling

Imaging techniques can provide information about the tumor non-invasively and have been shown to provide information about the underlying genetic makeup. Correlating image-based phenotypes (radiomics) with gen...

Authors: Albert C. Yeh, Hui Li, Yitan Zhu, Jing Zhang, Galina Khramtsova, Karen Drukker, Alexandra Edwards, Stephanie McGregor, Toshio Yoshimatsu, Yonglan Zheng, Qun Niu, Hiroyuki Abe, Jeffrey Mueller, Suzanne Conzen, Yuan Ji, Maryellen L. Giger…

Comparing clinicopathological features and prognosis of primary pulmonary invasive mucinous adenocarcinoma based on computed tomography findings

To evaluate the relationship between clinicopathologic characteristics and prognosis in patients with invasive mucinous adenocarcinoma (IMA) of the lung.

Authors: Kai Nie, Wei Nie, Yu-Xuan Zhang and Hong Yu

Does establishing a preoperative nomogram including ultrasonographic findings help predict the likelihood of malignancy in patients with microcalcifications?

Mammography (MG) is highly sensitive for detecting microcalcifications, but has low specificity. This study investigates whether establishing a preoperative nomogram including ultrasonographic findings can hel...

Authors: Hongli Wang, Jianguo Lai, Jiao Li, Ran Gu, Fengtao Liu, Yue Hu, Jingsi Mei, Xiaofang Jiang, Shiyu Shen, Fengyan Yu and Fengxi Su

Multi-window CT based Radiomic signatures in differentiating indolent versus aggressive lung cancers in the National Lung Screening Trial: a retrospective study

We retrospectively evaluated the capability of radiomic features to predict tumor growth in lung cancer screening and compared the performance of multi-window radiomic features and single window radiomic featu...

Authors: Hong Lu, Wei Mu, Yoganand Balagurunathan, Jin Qi, Mahmoud A. Abdalah, Alberto L. Garcia, Zhaoxiang Ye, Robert J. Gillies and Matthew B. Schabath

Percutaneous radiofrequency ablation of adrenal metastases from hepatocellular carcinoma: a single-center experience

The prognosis of adrenal metastases (AM) from hepatocellular carcinoma (HCC) with surgical contraindication was poor. This study evaluated the feasibility, safety and treatment efficacy of percutaneous ultraso...

Authors: Jingzhi Huang, Xiaohua Xie, Jinhua Lin, Wei Wang, Xiaoer Zhang, Ming Liu, Xiaoju Li, Guangliang Huang, Baoxian Liu and Xiaoyan Xie

Enhancing prognosis prediction using pre-treatment nodal SUVmax and HPV status in cervical squamous cell carcinoma

This study was to evaluate the prognostic value of metabolic parameters on F-18-FDG PET/CT and the status of human papillomavirus (HPV) infection and known prognostic variables for predicting tumor recurrence ...

Authors: Chae Moon Hong, Shin-Hyung Park, Gun Oh Chong, Yoon Hee Lee, Ju Hye Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn and Shin Young Jeong

Value of CT-guided percutaneous needle biopsy of bone in the diagnosis of lymphomas based on PET/CT results

To evaluate the value of CT-guided percutaneous needle biopsy of bone in the diagnosis of lymphomas based on PET/CT results.

Authors: Zhiwei Wang, Haifeng Shi, Xiaobo Zhang, Jie Pan and Zhengyu Jin

Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study

To determine if mammographic features from deep learning networks can be applied in breast cancer to identify groups at interval invasive cancer risk due to masking beyond using traditional breast density meas...

Authors: Benjamin Hinton, Lin Ma, Amir Pasha Mahmoudzadeh, Serghei Malkov, Bo Fan, Heather Greenwood, Bonnie Joe, Vivian Lee, Karla Kerlikowske and John Shepherd

Improved detection of metastatic lymph nodes in oesophageal squamous cell carcinoma by combined interpretation of fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography

We sought to evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography (¹⁸F-FDG PET/CT) in the detection of metastatic lymph nodes by combined interpre...

Authors: Ji Young Lee, Young Hwan Kim, Yong-Jin Park, Soo Bin Park, Hyun Woo Chung, Jae Il Zo, Young Mog Shim, Kyung Soo Lee and Joon Young Choi

Non-mono-exponential diffusion models for assessing early response of liver metastases to chemotherapy in colorectal Cancer

Preoperative chemotherapy is becoming standard therapy for liver metastasis from colorectal cancer, so early assessment of treatment response is crucial to make a reasonable therapeutic regimen and avoid overt...

Authors: Yang Zhou, Hong-Xia Zhang, Xiu-Shi Zhang, Yun-Feng Sun, Kuang-Bang He, Xi-Qiao Sang, Yue-Min Zhu and Zi-Xiang Kuai

Comparative effect of iso-osmolar versus low-osmolar contrast media on the incidence of contrast-induced acute kidney injury in diabetic patients: a systematic review and meta-analysis

Contrast-induced acute kidney injury (CI-AKI) is a major adverse effect caused by intravascular administration of iodinated contrast medium. Whether there is a difference in CI-AKI incidence between iso-osmola...

Authors: Fei Zhao, Rong Lei, Shi-Kun Yang, Min Luo, Wei Cheng, Ye-Qing Xiao, Xu-Wei Li, Jun Guo and Shao-Bin Duan

⁶⁸Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

The purpose of this study was to evaluate the imaging properties of hepatic metastases in ⁶⁸Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC).

Authors: Jonathan Damjanovic, Jan-Carlo Janssen, Vikas Prasad, Gerd Diederichs, Thula Walter, Winfried Brenner and Marcus R. Makowski

Predicting malignant potential of subsolid nodules: can radiomics preempt longitudinal follow up CT?

To assess if radiomics can differentiate benign and malignant subsolid lung nodules (SSNs) on baseline or follow up chest CT examinations. If radiomics can differentiate between benign and malignant subsolid l...

Authors: Subba R. Digumarthy, Atul M. Padole, Shivam Rastogi, Melissa Price, Meghan J. Mooradian, Lecia V. Sequist and Mannudeep K. Kalra

Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results

Correct staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial re...

Authors: Lisa C. Adams, Keno K. Bressem, Phillipp Jurmeister, Ute L. Fahlenkamp, Bernhard Ralla, Guenther Engel, Bernd Hamm, Jonas Busch and Marcus R. Makowski

CT imaging-based histogram features for prediction of EGFR mutation status of bone metastases in patients with primary lung adenocarcinoma

To identify imaging markers that reflect the epidermal growth factor receptor (EGFR) mutation status by comparing computed tomography (CT) imaging-based histogram features between bone metastases with and with...

Authors: Tong-xu Shen, Lin Liu, Wen-hui Li, Ping Fu, Kai Xu, Yu-qing Jiang, Feng Pan, Yan Guo and Meng-chao Zhang

Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules

For subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maxim...

Authors: Shingo Iwano, Hiroyasu Umakoshi, Shinichiro Kamiya, Kohei Yokoi, Koji Kawaguchi, Takayuki Fukui and Shinji Naganawa

Primary hepatic perivascular epithelioid cell tumors: imaging findings with histopathological correlation

Hepatic PEComas are very rare. Few systematic reports are available characterizing the imaging and pathological features of hepatic PEComa. The aim of this study was to investigate the imaging findings of prim...

Authors: Pei Nie, Jie Wu, Hexiang Wang, Ruizhi Zhou, Lingling Sun, Jingjing Chen and Guangjie Yang

Chemosaturation with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience

To investigate the outcome and safety data of chemosaturation with percutaneous hepatic perfusion (CS-PHP) of melphalan in patients with liver-dominant metastatic uveal melanoma.

Authors: Christoph Artzner, Oliver Mossakowski, Gerald Hefferman, Ulrich Grosse, Rüdiger Hoffmann, Andrea Forschner, Thomas Eigentler, Roland Syha and Gerd Grözinger

Comparison of diffusion kurtosis imaging versus diffusion weighted imaging in predicting the recurrence of early stage single nodules of hepatocellular carcinoma treated by radiofrequency ablation

This study aimed to compare the diffusion kurtosis imaging (DKI) versus diffusion weighted imaging (DWI) in predicting the recurrence of early stage single nodules of hepatocellular carcinoma (HCC) treated by ...

Authors: Zhen-Guo Yuan, Zong-Ying Wang, Meng-Ying Xia, Feng-Zhi Li, Yao Li, Zhen Shen and Xi-Zhen Wang

Prediction of hepatocellular carcinoma response to ⁹⁰Yttrium radioembolization using volumetric ADC histogram quantification: preliminary results

To assess the predictive value of volumetric apparent diffusion coefficient (vADC) histogram quantification obtained before and 6 weeks (6w) post-treatment for assessment of hepatocellular carcinoma (HCC) resp...

Authors: Sonja Gordic, Mathilde Wagner, Riccardo Zanato, Stefanie Hectors, Cecilia Besa, Shingo Kihira, Edward Kim and Bachir Taouli

The role of ¹⁸F-FDG-PET/CT in evaluating retroperitoneal masses -Keeping your eye on the ball!

Testicular germ cell tumour is the commonest malignancy affecting males aged between 15 and 35, with an increased relative risk amongst those with a history of cryptorchidism. In patients presenting with locor...

Authors: Te-Jui Hung, Luke McLean, Catherine Mitchell, Claire Pascoe, Nathan Lawrentschuk, Declan G. Murphy, Amir Iravani, Dalveer Singh, Michael S. Hofman, Lamiaa Zidan, Tim Akhurst, Jeremy Lewin and Rodney J. Hicks

Behavior of FDG-avid supradiaphragmatic lymph nodes in PET/CT throughout primary therapy in advanced serous epithelial ovarian cancer: a prospective study

Epithelial ovarian cancer (EOC) typically spreads intra-abdominally, but preoperative evaluation with FDG PET/CT often reveals metabolically active supradiaphragmatic lymph nodes (sdLNs). Their clinical signif...

Authors: Maren Laasik, Jukka Kemppainen, Annika Auranen, Sakari Hietanen, Seija Grénman, Marko Seppänen and Johanna Hynninen

Optimizing prostate cancer accumulating model: combined PI-RADS v2 with prostate specific antigen and its derivative data

To establish a new accumulating model to enhance the accuracy of prostate cancer (PCa) diagnosis by incorporating prostate-specific antigen (PSA) and its derivative data into the Prostate Imaging-Reporting and...

Authors: Yuan-Fei Lu, Qian Zhang, Wei-Gen Yao, Hai-Yan Chen, Jie-Yu Chen, Cong-Cong Xu and Ri-Sheng Yu

Quantitative computed tomography texture analysis: can it improve diagnostic accuracy to differentiate malignant lymph nodes?

Mediastinal lymph node (LN) staging in individuals with non-small-cell lung cancer plays an important role in staging and treatment planning. This study aimed to assess the accuracy of computed tomography (CT)...

Authors: So Youn Shin, Il Ki Hong and Yong Suk Jo

Diagnostic value of multislice spiral computed tomography (CT) combined with CT angiography for intra-abdominal undescended testis secondary seminomas

To discuss the diagnostic value of multislice spiral tomography (CT) combined with CT angiography (CTA) technology in intra-abdominal undescended testis secondary seminoma cases.

Authors: Si-qi Wang, Fang-yuan Ren, Jian-hua Wang, Zhi-hao Ren, Zhong-gao Jin, Yu Xu, Zhen-hui Li, Qian-jiang Ding and Chao Zhong

Intra-individual comparison of ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL normal-organ biodistribution

Detailed data comparing the biodistribution of PSMA radioligands is still scarce, raising concerns regarding the comparability of different compounds. We investigated differences in normal-organ biodistributio...

Authors: Gonçalo Ferreira, Amir Iravani, Michael S. Hofman and Rodney J. Hicks

Hepatocellular carcinoma: radiomics nomogram on gadoxetic acid-enhanced MR imaging for early postoperative recurrence prediction

This study was performed to prospectively develop and validate a radiomics nomogram for predicting postoperative early recurrence (≤1 year) of hepatocellular carcinoma (HCC) using whole-lesion radiomics featur...

Authors: Zhen Zhang, Hanyu Jiang, Jie Chen, Yi Wei, Likun Cao, Zheng Ye, Xin Li, Ling Ma and Bin Song

Prediction early recurrence of hepatocellular carcinoma eligible for curative ablation using a Radiomics nomogram

Predicting early recurrence (ER) after radical therapy for HCC patients is critical for the decision of subsequent follow-up and treatment. Radiomic features derived from the medical imaging show great potenti...

Authors: Chunwang Yuan, Zhenchang Wang, Dongsheng Gu, Jie Tian, Peng Zhao, Jingwei Wei, Xiaozhen Yang, Xiaohan Hao, Di Dong, Ning He, Yu Sun, Wenfeng Gao and Jiliang Feng

Investigating the diagnostic value of quantitative parameters based on T2-weighted and contrast-enhanced MRI with psoas muscle and outer myometrium as internal references for differentiating uterine sarcomas from leiomyomas at 3T MRI

Post-hysterectomy histopathological examination is currently the main diagnostic tool for differentiating uterine sarcomas from leiomyomas. This study aimed to investigate the diagnostic accuracy of preoperati...

Authors: Mahrooz Malek, Maryam Rahmani, Seyyedeh Mahdieh Seyyed Ebrahimi, Elnaz Tabibian, Azadeh Alidoosti, Pariya Rahimifar, Setareh Akhavan and Ziba Gandomkar

Application of a machine learning method to whole brain white matter injury after radiotherapy for nasopharyngeal carcinoma

The purpose/aim of this study was to 1) use magnetic resonance diffusion tensor imaging (DTI), fibre bundle/tract-based spatial statistics (TBSS) and machine learning methods to study changes in the white matt...

Authors: Xi Leng, Peng Fang, Huan Lin, Chunhong Qin, Xin Tan, Yi Liang, Chi Zhang, Hongzhuo Wang, Jie An, Donglin Wu, Qihui Liu and Shijun Qiu

Metabolic tumor burden on postsurgical PET/CT predicts survival of patients with gastric cancer

The prognostic value of postoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with gastric cancer remains unclear. This study aims to investigate the...

Authors: Gaofeng Sun, Chao Cheng, Xiao Li, Tao Wang, Jian Yang and Danni Li

Choroid plexus tumours on MRI: similarities and distinctions in different grades

The therapeutic planning varies for different grades of choroid plexus tumours (CPTs). The aim of this study was to define the similarities and distinctions among MRIs for different grades of CPTs, providing m...

Authors: Huan Lin, Xi Leng, Chun-hong Qin, Yong-xing Du, Wen-sheng Wang and Shi-jun Qiu

Ultrasound-guided percutaneous laser ablation for papillary thyroid microcarcinoma: a retrospective analysis of 37 patients

Over the past ten years, more papillary thyroid microcarcinoma (PTMC) has been diagnosed more frequently due to the development of imaging technology, and the incidence of PTMC has increased significantly. Ult...

Authors: Lili Ji, Qin Wu, Jun Gu, Xuedong Deng, Wei Zhou, Xing Fan and Feng Zhou

Evaluation of percutaneous unilateral trans-femoral implantation of side-hole port-catheter system with coil only fixed-catheter-tip for hepatic arterial infusion chemotherapy

The technique for arterial infusion chemotherapy (HAIC) is not standardized which limits its widely application. The aim of this study was to evaluate the long-term functionality and complications of port-cath...

Authors: Jungang Hu, Xu Zhu, Xiaodong Wang, Guang Cao, Xiao Wang and Renjie Yang

Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors

To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibil...

Authors: Ararat Chakhoyan, Catalina Raymond, Jason Chen, Jodi Goldman, Jingwen Yao, Tania B. Kaprealian, Nader Pouratian and Benjamin M. Ellingson

Asymptomatic versus symptomatic solid pseudopapillary tumors of the pancreas: clinical and MDCT manifestations

To delineate the features of multi-detector computed tomography (MDCT) images and clinical characteristics of pancreatic solid pseudopapillary tumors (SPTs) of the pancreas in asymptomatic patients and compare...

Authors: Shudong Hu, Heng Zhang, Xian Wang, Zongqiong Sun, Yuxi Ge, Gen Yan, Changyong Zhao and Kemin Chen

RETRACTED ARTICLE: Ultrasound Elastography supplement assessing nodal status of magnetic resonance imaging staged cervical N0 patients with nasopharyngeal carcinoma

To determine whether ultrasound elastography can distinguish reactive or metastatic small lymph nodes (sLN) of magnetic resonance imaging (MRI) staged cervical N0 patients with nasopharyngeal carcinoma (NPC).

Authors: Jian Li, Fei Han, Yunxian Mo, Xindan Chen, Yong Li and Feifei Zuo

CT-based peritumoral radiomics signatures to predict early recurrence in hepatocellular carcinoma after curative tumor resection or ablation

To construct a prediction model based on peritumoral radiomics signatures from CT images and investigate its efficiency in predicting early recurrence (ER) of hepatocellular carcinoma (HCC) after curative trea...

Authors: Quan-yuan Shan, Hang-tong Hu, Shi-ting Feng, Zhen-peng Peng, Shu-ling Chen, Qian Zhou, Xin Li, Xiao-yan Xie, Ming-de Lu, Wei Wang and Ming Kuang

Dynamic contrast-enhanced MRI of malignant pleural mesothelioma: a comparative study of pharmacokinetic models and correlation with mRECIST criteria

Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvas...

Authors: Martina Vivoda Tomšič, Sotirios Bisdas, Viljem Kovač, Igor Serša and Katarina Šurlan Popovič

Comparative analysis of the value of diffusion kurtosis imaging and diffusion-weighted imaging in evaluating the histological features of endometrial cancer

This study evaluated and compared the performances of diffusion kurtosis imaging (DKI) and diffusion-weighted imaging (DWI) for diagnosing and histologically grading endometrial cancer.

Authors: Wei Yue, Nan Meng, Jing Wang, Wenling Liu, Xuejia Wang, Minghuan Yan, Dongming Han and Jingliang Cheng

Application of magnetic resonance diffusion kurtosis imaging for distinguishing histopathologic subtypes and grades of rectal carcinoma

To evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) for distinguishing different histopathological subtypes and grades of rectal carcinoma and to compare DKI with conventional diffusion-...

Authors: Ziqiang Wen, Yan Chen, Xinyue Yang, Baolan Lu, Yiyan Liu, Bingqi Shen and Shenping Yu

2020 vision or myopia? A personal perspective on the future of cancer imaging and an introduction to the sequels to the “How I Read Series”

Authors: Rodney J. Hicks