Articles

Tumor treating fields in the management of Glioblastoma: opportunities for advanced imaging

Alternating electric fields have been successfully applied to cancer cells in-vitro to disrupt malignant progression and this antimitotic therapy has now been proven to be efficacious in Phase II and Phase III...

Authors: Vikram S. Soni and Ted K. Yanagihara

Lipiodol retention pattern after TACE for HCC is a predictor for local progression in lesions with complete response

To evaluate the predictive value of the lipiodol retention pattern for local progression of HCC with a complete response (CR) on CT according to mRECIST criteria after a first session of conventional chemoembo...

Authors: Marco Dioguardi Burgio, Riccardo Sartoris, Claudia Libotean, Magaly Zappa, Annie Sibert, Valérie Vilgrain and Maxime Ronot

Diffusion-weighted imaging for identifying patients at high risk of tumor recurrence following liver transplantation

Tumor recurrence is the major risk factor affecting post-transplant survival. In this retrospective study, we evaluate the prognostic values of magnetic resonance (MR) diffusion-weighted imaging (DWI) in liver...

Authors: Yi-Hsuan Chuang, Hsin-You Ou, Chun-Yen Yu, Chao-Long Chen, Ching-Chun Weng, Leo Leung-Chit Tsang, Hsien-Wen Hsu, Wei-Xiong Lim, Tung-Liang Huang and Yu-Fan Cheng

The added diagnostic value of complementary gadoxetic acid-enhanced MRI to ¹⁸F-DOPA-PET/CT for liver staging in medullary thyroid carcinoma

A high proportion of patients with advanced stages of medullary thyroid carcinoma (MTC) present with liver metastasis metastases. The aim of our study was to investigate the added diagnostic value of complemen...

Authors: Daniel Puhr-Westerheide, Clemens C. Cyran, Josef Sargsyan-Bergmann, Andrei Todica, Franz-Josef Gildehaus, Wolfgang G. Kunz, Robert Stahl, Christine Spitzweg, Jens Ricke and Philipp M. Kazmierczak

CT lymphography for sentinel lymph node mapping of clinically N0 early oral cancer

The objectives of this retrospective study were to evaluate the usefulness of computed tomography lymphography (CTL) and to clarify the optimal timing of CTL in sentinel lymph node (SLN) mapping of clinically ...

Authors: Satomi Sugiyama, Toshinori Iwai, Toshiharu Izumi, Keita Ishiguro, Junichi Baba, Senri Oguri and Kenji Mitsudo

Local application of doxorubicin- loaded Iron oxid nanoparticles and the vascular disrupting agent via the hepatic artery: chemoembolization–photothermal ablation treatment of hepatocellular carcinoma in rats

This study investigates the effectiveness of local application of doxorubicin(Dox)-loaded, polydopamine (PDA)- coated single crystal hematite (α- Fe₂O₃) nanocubes (Fe₂O₃-PDA-Dox) and combretastatin A-4 phosphate ...

Authors: Hongjun Yuan, Xin Li, Jing Tang, Min Zhou and Fengyong Liu

Non-invasive MR assessment of the microstructure and microcirculation in regional lymph nodes for rectal cancer: a study of intravoxel incoherent motion imaging

The aim of this study is to evaluate the microstructure and microcirculation of regional lymph nodes (LNs) in rectal cancer by using non-invasive intravoxel incoherent motion MRI (IVIM-MRI), and to distinguish...

Authors: Xinyue Yang, Yan Chen, Ziqiang Wen, Yiyan Liu, Xiaojuan Xiao, Wen Liang and Shenping Yu

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biop...

Authors: Min-hao Wu, Ling-fei Xiao, Huo-wen Liu, Zhi-qiang Yang, Xiao-xiao Liang, Yan Chen, Jun Lei and Zhou-ming Deng

Radiogenomic analysis of vascular endothelial growth factor in patients with diffuse gliomas

To predict vascular endothelial growth factor (VEGF) expression in patients with diffuse gliomas using radiomic analysis.

Authors: Zhiyan Sun, Yiming Li, Yinyan Wang, Xing Fan, Kaibin Xu, Kai Wang, Shaowu Li, Zhong Zhang, Tao Jiang and Xing Liu

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Increasing numbers of breast cancer patients receive neoadjuvant chemotherapy (NACT). We seek to investigate whether baseline mammographic and ultrasound features are associated with complete pathological resp...

Authors: Sarah L. Savaridas, Yee Ting Sim, Sarah J. Vinnicombe, Colin A. Purdie, Alastair M. Thompson and Andy Evans

CT radiomic features for predicting resectability of oesophageal squamous cell carcinoma as given by feature analysis: a case control study

Computed tomography (CT) is commonly used in all stages of oesophageal squamous cell carcinoma (SCC) management. Compared to basic CT features, CT radiomic features can objectively obtain more information abou...

Authors: Jing Ou, Rui Li, Rui Zeng, Chang-qiang Wu, Yong Chen, Tian-wu Chen, Xiao-ming Zhang, Lan Wu, Yu Jiang, Jian-qiong Yang, Jin-ming Cao, Sun Tang, Meng-jie Tang and Jiani Hu

Neurosurgical applications of MRI guided laser interstitial thermal therapy (LITT)

MRI-guided laser interstitial thermal therapy (LITT) is the selective ablation of a lesion or a tissue using heat emitted from a laser device. LITT is considered a less invasive technique compared to open surg...

Authors: Usama Salem, Vinodh A. Kumar, John E. Madewell, Donald F. Schomer, Dhiego Chaves de Almeida Bastos, Pascal O. Zinn, Jeffrey S. Weinberg, Ganesh Rao, Sujit S. Prabhu and Rivka R. Colen

Independent validation of machine learning in diagnosing breast Cancer on magnetic resonance imaging within a single institution

As artificial intelligence methods for the diagnosis of disease advance, we aimed to evaluate machine learning in the predictive task of distinguishing between malignant and benign breast lesions on an indepen...

Authors: Yu Ji, Hui Li, Alexandra V. Edwards, John Papaioannou, Wenjuan Ma, Peifang Liu and Maryellen L. Giger

Utility of diffusion-weighted and contrast-enhanced magnetic resonance imaging in diagnosing and differentiating between high- and low-grade uterine endometrial stromal sarcoma

Endometrial stromal sarcoma (ESS) is a rare uterine malignancy that features different prognoses for its high- and low-grade subtypes. We investigated the diagnostic accuracy of magnetic resonance (MR) imaging...

Authors: Yen-Ling Huang, Shir-Hwa Ueng, Kueian Chen, Yu-Ting Huang, Hsin-Ying Lu, Koon-Kwan Ng, Ting-Chang Chang, Chyong-Huey Lai and Gigin Lin

The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course

Authors:

Early differentiating between the chemotherapy responders and nonresponders: preliminary results with ultrasonic spectrum analysis of the RF time series in preclinical breast cancer models

This study was aimed to assess whether ultrasonic spectrum analysis of radiofrequency (RF) time series using a clinical ultrasound system allows for early differentiating between the chemotherapy responders an...

Authors: Fei Li, Yini Huang, Jianwei Wang, Chunyi Lin, Qing Li, Xueyi Zheng, Yun Wang, Longhui Cao and Jianhua Zhou

Radiomics models for diagnosing microvascular invasion in hepatocellular carcinoma: which model is the best model?

To explore the feasibility of diagnosing microvascular invasion (MVI) with radiomics, to compare the diagnostic performance of different models established by each method, and to determine the best diagnostic ...

Authors: Ming Ni, Xiaoming Zhou, Qian Lv, Zhiming Li, Yuanxiang Gao, Yongqi Tan, Jihua Liu, Fang Liu, Haiyang Yu, Linlin Jiao and Gang Wang

Diffusion-weighted magnetic resonance imaging in bladder cancer: comparison of readout-segmented and single-shot EPI techniques

To evaluate whether readout-segment echo-planar imaging (RS-EPI) can provide better image quality in assessing bladder cancer than single-shot echo-planar imaging (SS-EPI) and to compare quantitative imaging p...

Authors: Haihu Chen, Luguang Chen, Fang Liu, Jianping Lu, Chuanliang Xu and Li Wang

¹⁸F-FDG-PET-based Radiomics signature predicts MGMT promoter methylation status in primary diffuse glioma

The methylation status of the O⁶-methylguanine-DNA methyltransferase (MGMT) promoter has emerged as a favorable independent prognostic and predictive biomarker in glioma. This study aimed to build a radiomics sig...

Authors: Ziren Kong, Yusong Lin, Chendan Jiang, Longfei Li, Zehua Liu, Yuekun Wang, Congxin Dai, Delin Liu, Xuying Qin, Yu Wang, Zhenyu Liu, Xin Cheng, Jie Tian and Wenbin Ma

How we read: the combined use of MRI and novel PET tracers for the characterisation and treatment planning of masses in neuro-oncology

Technical advances in imaging are well demonstrated by MRI (Magnetic Resonance Imaging) and PET (Positron Emission Tomography). Excellent anatomical detail and a lack of ionising radiation make MRI the standar...

Authors: Arian Lasocki and Rodney J. Hicks

Using neighborhood gray tone difference matrix texture features on dual time point PET/CT images to differentiate malignant from benign FDG-avid solitary pulmonary nodules

Lung cancer usually presents as a solitary pulmonary nodule (SPN) on diagnostic imaging during the early stages of the disease. Since the early diagnosis of lung cancer is very important for treatment, the acc...

Authors: Song Chen, Stephanie Harmon, Timothy Perk, Xuena Li, Meijie Chen, Yaming Li and Robert Jeraj

Retraction Note to: Ultrasound Elastography supplement assessing nodal status of magnetic resonance imaging staged cervical N0 patients with nasopharyngeal carcinoma

The Editors have retracted this article [1] because figure 2 has been substantially duplicated from a previously published article by Chen B et al., 2018 [2]. There is also significant and uncited overlap in t...

Authors: Jian Li, Fei Han, Yunxian Mo, Xindan Chen, Yong Li and Feifei Zuo

Clinical impact of variability on CT radiomics and suggestions for suitable feature selection: a focus on lung cancer

Radiomics suffers from feature reproducibility. We studied the variability of radiomics features and the relationship of radiomics features with tumor size and shape to determine guidelines for optimal radiomi...

Authors: Seung-Hak Lee, Hwan-ho Cho, Ho Yun Lee and Hyunjin Park

Imaging and clinical features of Castleman Disease

Castleman disease (CD) is a group of uncommon lymphoproliferative disorders that is easily confused with lymphoma or other solid tumors. The purpose of our study was to evaluate the imaging and clinical findin...

Authors: Shuang Zhao, Ying Wan, Zixing Huang, Bin Song and Jianqun Yu

PET/MRI and PET/CT hybrid imaging of rectal cancer – description and initial observations from the RECTOPET (REctal Cancer trial on PET/MRI/CT) study

The role of hybrid imaging using ¹⁸F-fluoro-2-deoxy-D-glucose positron-emission tomography (FDG-PET), computed tomography (CT) and magnetic resonance imaging (MRI) to improve preoperative evaluation of rectal can...

Authors: Miriam K. Rutegård, Malin Båtsman, Jan Axelsson, Patrik Brynolfsson, Fredrik Brännström, Jörgen Rutegård, Ingrid Ljuslinder, Lennart Blomqvist, Richard Palmqvist, Martin Rutegård and Katrine Riklund

Accuracy and complications of CT-guided pulmonary core biopsy in small nodules: a single-center experience

Computed tomography (CT)-guided pulmonary core biopsies of small pulmonary nodules less than 15 millimeters (mm) are challenging for radiologists, and their diagnostic accuracy has been shown to be variable in...

Authors: Ming-De Huang, Hsu-Huei Weng, Sheng-Lung Hsu, Li-Sheng Hsu, Wei-Ming Lin, Chien-Wei Chen and Yuan-Hsiung Tsai

Diagnostic value of spectral reconstructions in detecting incidental skeletal muscle metastases in CT staging examinations

To investigate if iodine density overlay maps (IDO) and virtual monoenergetic images at 40 keV (VMI_40keV) acquired from spectral detector computed tomography (SDCT) can improve detection of incidental skeletal mu...

Authors: Simon Lennartz, Nils Große Hokamp, Nuran Abdullayev, Markus Le Blanc, Andra-Iza Iuga, Grischa Bratke, David Zopfs, David Maintz, Jan Borggrefe and Thorsten Persigehl

Prediction for early recurrence of intrahepatic mass-forming cholangiocarcinoma: quantitative magnetic resonance imaging combined with prognostic immunohistochemical markers

Partial hepatectomy is the first option for intrahepatic mass-forming cholangiocarcinoma (IMCC) treatment, which would prolong survival. The main reason for the poor outcome after curative resection is the hig...

Authors: Li Zhao, Xiaohong Ma, Meng Liang, Dengfeng Li, Peiqing Ma, Sicong Wang, Zhiyuan Wu and Xinming Zhao

Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling

Imaging techniques can provide information about the tumor non-invasively and have been shown to provide information about the underlying genetic makeup. Correlating image-based phenotypes (radiomics) with gen...

Authors: Albert C. Yeh, Hui Li, Yitan Zhu, Jing Zhang, Galina Khramtsova, Karen Drukker, Alexandra Edwards, Stephanie McGregor, Toshio Yoshimatsu, Yonglan Zheng, Qun Niu, Hiroyuki Abe, Jeffrey Mueller, Suzanne Conzen, Yuan Ji, Maryellen L. Giger…

Comparing clinicopathological features and prognosis of primary pulmonary invasive mucinous adenocarcinoma based on computed tomography findings

To evaluate the relationship between clinicopathologic characteristics and prognosis in patients with invasive mucinous adenocarcinoma (IMA) of the lung.

Authors: Kai Nie, Wei Nie, Yu-Xuan Zhang and Hong Yu

Does establishing a preoperative nomogram including ultrasonographic findings help predict the likelihood of malignancy in patients with microcalcifications?

Mammography (MG) is highly sensitive for detecting microcalcifications, but has low specificity. This study investigates whether establishing a preoperative nomogram including ultrasonographic findings can hel...

Authors: Hongli Wang, Jianguo Lai, Jiao Li, Ran Gu, Fengtao Liu, Yue Hu, Jingsi Mei, Xiaofang Jiang, Shiyu Shen, Fengyan Yu and Fengxi Su

Multi-window CT based Radiomic signatures in differentiating indolent versus aggressive lung cancers in the National Lung Screening Trial: a retrospective study

We retrospectively evaluated the capability of radiomic features to predict tumor growth in lung cancer screening and compared the performance of multi-window radiomic features and single window radiomic featu...

Authors: Hong Lu, Wei Mu, Yoganand Balagurunathan, Jin Qi, Mahmoud A. Abdalah, Alberto L. Garcia, Zhaoxiang Ye, Robert J. Gillies and Matthew B. Schabath

Percutaneous radiofrequency ablation of adrenal metastases from hepatocellular carcinoma: a single-center experience

The prognosis of adrenal metastases (AM) from hepatocellular carcinoma (HCC) with surgical contraindication was poor. This study evaluated the feasibility, safety and treatment efficacy of percutaneous ultraso...

Authors: Jingzhi Huang, Xiaohua Xie, Jinhua Lin, Wei Wang, Xiaoer Zhang, Ming Liu, Xiaoju Li, Guangliang Huang, Baoxian Liu and Xiaoyan Xie

Enhancing prognosis prediction using pre-treatment nodal SUVmax and HPV status in cervical squamous cell carcinoma

This study was to evaluate the prognostic value of metabolic parameters on F-18-FDG PET/CT and the status of human papillomavirus (HPV) infection and known prognostic variables for predicting tumor recurrence ...

Authors: Chae Moon Hong, Shin-Hyung Park, Gun Oh Chong, Yoon Hee Lee, Ju Hye Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn and Shin Young Jeong

Value of CT-guided percutaneous needle biopsy of bone in the diagnosis of lymphomas based on PET/CT results

To evaluate the value of CT-guided percutaneous needle biopsy of bone in the diagnosis of lymphomas based on PET/CT results.

Authors: Zhiwei Wang, Haifeng Shi, Xiaobo Zhang, Jie Pan and Zhengyu Jin

Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study

To determine if mammographic features from deep learning networks can be applied in breast cancer to identify groups at interval invasive cancer risk due to masking beyond using traditional breast density meas...

Authors: Benjamin Hinton, Lin Ma, Amir Pasha Mahmoudzadeh, Serghei Malkov, Bo Fan, Heather Greenwood, Bonnie Joe, Vivian Lee, Karla Kerlikowske and John Shepherd

Improved detection of metastatic lymph nodes in oesophageal squamous cell carcinoma by combined interpretation of fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography

We sought to evaluate the diagnostic performance of fluorine-18-fluorodeoxyglucose positron-emission tomography/computed tomography (¹⁸F-FDG PET/CT) in the detection of metastatic lymph nodes by combined interpre...

Authors: Ji Young Lee, Young Hwan Kim, Yong-Jin Park, Soo Bin Park, Hyun Woo Chung, Jae Il Zo, Young Mog Shim, Kyung Soo Lee and Joon Young Choi

Non-mono-exponential diffusion models for assessing early response of liver metastases to chemotherapy in colorectal Cancer

Preoperative chemotherapy is becoming standard therapy for liver metastasis from colorectal cancer, so early assessment of treatment response is crucial to make a reasonable therapeutic regimen and avoid overt...

Authors: Yang Zhou, Hong-Xia Zhang, Xiu-Shi Zhang, Yun-Feng Sun, Kuang-Bang He, Xi-Qiao Sang, Yue-Min Zhu and Zi-Xiang Kuai

Comparative effect of iso-osmolar versus low-osmolar contrast media on the incidence of contrast-induced acute kidney injury in diabetic patients: a systematic review and meta-analysis

Contrast-induced acute kidney injury (CI-AKI) is a major adverse effect caused by intravascular administration of iodinated contrast medium. Whether there is a difference in CI-AKI incidence between iso-osmola...

Authors: Fei Zhao, Rong Lei, Shi-Kun Yang, Min Luo, Wei Cheng, Ye-Qing Xiao, Xu-Wei Li, Jun Guo and Shao-Bin Duan

⁶⁸Ga-PSMA-PET/CT for the evaluation of liver metastases in patients with prostate cancer

The purpose of this study was to evaluate the imaging properties of hepatic metastases in ⁶⁸Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC).

Authors: Jonathan Damjanovic, Jan-Carlo Janssen, Vikas Prasad, Gerd Diederichs, Thula Walter, Winfried Brenner and Marcus R. Makowski

Predicting malignant potential of subsolid nodules: can radiomics preempt longitudinal follow up CT?

To assess if radiomics can differentiate benign and malignant subsolid lung nodules (SSNs) on baseline or follow up chest CT examinations. If radiomics can differentiate between benign and malignant subsolid l...

Authors: Subba R. Digumarthy, Atul M. Padole, Shivam Rastogi, Melissa Price, Meghan J. Mooradian, Lecia V. Sequist and Mannudeep K. Kalra

Use of quantitative T2 mapping for the assessment of renal cell carcinomas: first results

Correct staging and grading of patients with clear cell renal cell carcinoma (cRCC) is of clinical relevance for the prediction of operability and for individualized patient management. As partial or radial re...

Authors: Lisa C. Adams, Keno K. Bressem, Phillipp Jurmeister, Ute L. Fahlenkamp, Bernhard Ralla, Guenther Engel, Bernd Hamm, Jonas Busch and Marcus R. Makowski

CT imaging-based histogram features for prediction of EGFR mutation status of bone metastases in patients with primary lung adenocarcinoma

To identify imaging markers that reflect the epidermal growth factor receptor (EGFR) mutation status by comparing computed tomography (CT) imaging-based histogram features between bone metastases with and with...

Authors: Tong-xu Shen, Lin Liu, Wen-hui Li, Ping Fu, Kai Xu, Yu-qing Jiang, Feng Pan, Yan Guo and Meng-chao Zhang

Postoperative recurrence of clinical early-stage non-small cell lung cancers: a comparison between solid and subsolid nodules

For subsolid non-small cell lung cancers (NSCLCs), solid size (SS), which is the maximal diameter of the solid component, correlates more accurately with tumor prognosis than the total size, which is the maxim...

Authors: Shingo Iwano, Hiroyasu Umakoshi, Shinichiro Kamiya, Kohei Yokoi, Koji Kawaguchi, Takayuki Fukui and Shinji Naganawa

Primary hepatic perivascular epithelioid cell tumors: imaging findings with histopathological correlation

Hepatic PEComas are very rare. Few systematic reports are available characterizing the imaging and pathological features of hepatic PEComa. The aim of this study was to investigate the imaging findings of prim...

Authors: Pei Nie, Jie Wu, Hexiang Wang, Ruizhi Zhou, Lingling Sun, Jingjing Chen and Guangjie Yang

Chemosaturation with percutaneous hepatic perfusion of melphalan for liver-dominant metastatic uveal melanoma: a single center experience

To investigate the outcome and safety data of chemosaturation with percutaneous hepatic perfusion (CS-PHP) of melphalan in patients with liver-dominant metastatic uveal melanoma.

Authors: Christoph Artzner, Oliver Mossakowski, Gerald Hefferman, Ulrich Grosse, Rüdiger Hoffmann, Andrea Forschner, Thomas Eigentler, Roland Syha and Gerd Grözinger

Comparison of diffusion kurtosis imaging versus diffusion weighted imaging in predicting the recurrence of early stage single nodules of hepatocellular carcinoma treated by radiofrequency ablation

This study aimed to compare the diffusion kurtosis imaging (DKI) versus diffusion weighted imaging (DWI) in predicting the recurrence of early stage single nodules of hepatocellular carcinoma (HCC) treated by ...

Authors: Zhen-Guo Yuan, Zong-Ying Wang, Meng-Ying Xia, Feng-Zhi Li, Yao Li, Zhen Shen and Xi-Zhen Wang

Prediction of hepatocellular carcinoma response to ⁹⁰Yttrium radioembolization using volumetric ADC histogram quantification: preliminary results

To assess the predictive value of volumetric apparent diffusion coefficient (vADC) histogram quantification obtained before and 6 weeks (6w) post-treatment for assessment of hepatocellular carcinoma (HCC) resp...

Authors: Sonja Gordic, Mathilde Wagner, Riccardo Zanato, Stefanie Hectors, Cecilia Besa, Shingo Kihira, Edward Kim and Bachir Taouli

The role of ¹⁸F-FDG-PET/CT in evaluating retroperitoneal masses -Keeping your eye on the ball!

Testicular germ cell tumour is the commonest malignancy affecting males aged between 15 and 35, with an increased relative risk amongst those with a history of cryptorchidism. In patients presenting with locor...

Authors: Te-Jui Hung, Luke McLean, Catherine Mitchell, Claire Pascoe, Nathan Lawrentschuk, Declan G. Murphy, Amir Iravani, Dalveer Singh, Michael S. Hofman, Lamiaa Zidan, Tim Akhurst, Jeremy Lewin and Rodney J. Hicks

Behavior of FDG-avid supradiaphragmatic lymph nodes in PET/CT throughout primary therapy in advanced serous epithelial ovarian cancer: a prospective study

Epithelial ovarian cancer (EOC) typically spreads intra-abdominally, but preoperative evaluation with FDG PET/CT often reveals metabolically active supradiaphragmatic lymph nodes (sdLNs). Their clinical signif...

Authors: Maren Laasik, Jukka Kemppainen, Annika Auranen, Sakari Hietanen, Seija Grénman, Marko Seppänen and Johanna Hynninen