Articles

FDG-PET/CT imaging for evaluating durable responses to immune check point inhibitors in patients with advanced cutaneous squamous cell carcinoma

The role of FDG-PET/CT imaging in assessing response to immunotherapy in advanced cutaneous squamous cell carcinoma (CSCC) is unknown. This study compared complete metabolic response (CMR) rates by FDG-PET and...

Authors: Luke S. McLean, Karda Cavanagh, Rodney J. Hicks, Jason Callahan, Jing Xie, Anthony Cardin, Annette M. Lim and Danny Rischin

Predicting microvascular invasion in hepatocellular carcinoma: a deep learning model validated across hospitals

The accuracy of estimating microvascular invasion (MVI) preoperatively in hepatocellular carcinoma (HCC) by clinical observers is low. Most recent studies constructed MVI predictive models utilizing radiologic...

Authors: Shu-Cheng Liu, Jesyin Lai, Jhao-Yu Huang, Chia-Fong Cho, Pei Hua Lee, Min-Hsuan Lu, Chun-Chieh Yeh, Jiaxin Yu and Wei-Ching Lin

Clustering subtypes of breast cancer by combining immunohistochemistry profiles and metabolism characteristics measured using FDG PET/CT

The aim of this study was to investigate the effect of combining immunohistochemical profiles and metabolic information to characterize breast cancer subtypes.

Authors: Hyun Woo Kwon, Jeong Hyeon Lee, Kisoo Pahk, Kyong Hwa Park and Sungeun Kim

Differentiating prostate cancer from benign prostatic hyperplasia using whole-lesion histogram and texture analysis of diffusion- and T2-weighted imaging

To explore the usefulness of analyzing histograms and textures of apparent diffusion coefficient (ADC) maps and T2-weighted (T2W) images to differentiate prostatic cancer (PCa) from benign prostatic hyperplasi...

Authors: Pengyi Xing, Luguang Chen, Qingsong Yang, Tao Song, Chao Ma, Robert Grimm, Caixia Fu, Tiegong Wang, Wenjia Peng and Jianping Lu

Proceedings of the International Cancer Imaging Society Meeting and 20th Annual Teaching Course

Authors:

CT and MRI findings of cystic renal cell carcinoma: comparison with cystic collecting duct carcinoma

Cystic renal cell carcinoma (CRCC) and cystic collecting duct carcinoma (CCDC) share similar oncogeni and some imaging findings. The aim of this study was to characterize the clinical and CT imagings features ...

Authors: Qingqiang Zhu, Jun Ling, Jing Ye, Wenrong Zhu, Jingtao Wu and Wenxin Chen

Emergency room imaging in pediatric patients with cancer: analysis of the spectrum and frequency of imaging modalities and findings in a tertiary cancer center and their relationship with survival

To assess the spectrum and frequency of modalities used for emergency room (ER) imaging and their findings in pediatric cancer patients and assess their relationship with survival.

Authors: Sungmin Woo, Abdallah Araji, Mohammad Ali El Amine, Natalie Gangai, Elizabeth Acquafredda, Anita P. Price, Tanya M. Trippett, Hedvig Hricak, Hebert Alberto Vargas and Gerald G. Behr

Tumor stiffness measured by 3D magnetic resonance elastography can help predict the aggressiveness of endometrial carcinoma: preliminary findings

Preoperative evaluation of aggressiveness, including tumor histological subtype, grade of differentiation, Federation International of Gynecology and Obstetrics (FIGO) stage, and depth of myometrial invasion, ...

Authors: Linqi Zhang, Xi Long, Mayidili Nijiati, Tianhui Zhang, Mengsi Li, Ying Deng, Sichi Kuang, Yuanqiang Xiao, Jie Zhu, Bingjun He, Jingbiao Chen, Phillip Rossman, Kevin J Glaser, Sudhakar K Venkatesh, Richard L Ehman and Jin Wang

Applying arterial enhancement fraction (AEF) texture features to predict the tumor response in hepatocellular carcinoma (HCC) treated with Transarterial chemoembolization (TACE)

To evaluate the application of Arterial Enhancement Fraction (AEF) texture features in predicting the tumor response in Hepatocellular Carcinoma (HCC) treated with Transarterial Chemoembolization (TACE) by mea...

Authors: Xiaonan Mao, Yan Guo, Feng Wen, Hongyuan Liang, Wei Sun and Zaiming Lu

Implementing CT tumor volume and CT pleural thickness into future staging systems for malignant pleural mesothelioma

Tumor thickness and tumor volume measured by computed tomography (CT) were suggested as valuable prognosticator for patients’ survival diagnosed with malignant pleural mesothelioma (MPM). The purpose was to as...

Authors: Olivia Lauk, Miriam Patella, Thomas Neuer, Bianca Battilana, Thomas Frauenfelder, Thi Dan Linh Nguyen-Kim, Walter Weder, Claudio Caviezel, Sven Hillinger, Ilhan Inci and Isabelle Opitz

Differentiation of renal angiomyolipoma without visible fat from small clear cell renal cell carcinoma by using specific region of interest on contrast-enhanced CT: a new combination of quantitative tools

To investigate the value of using specific region of interest (ROI) on contrast-enhanced CT for differentiating renal angiomyolipoma without visible fat (AML.wovf) from small clear cell renal cell carcinoma (c...

Authors: Xu Wang, Ge Song and Haitao Jiang

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

To investigate the performance of magnetic resonance imaging (MRI)-based radiomics models for benign and malignant prostate lesion discrimination and extracapsular extension (ECE) and positive surgical margins...

Authors: Dong He, Ximing Wang, Chenchao Fu, Xuedong Wei, Jie Bao, Xuefu Ji, Honglin Bai, Wei Xia, Xin Gao, Yuhua Huang and Jianquan Hou

Can preoperative liver MRI with gadoxetic acid help reduce open-close laparotomies for curative intent pancreatic cancer surgery?

To evaluate gadoxetic acid-enhanced liver MRI (EOB-MRI) versus contrast-enhanced computed tomography (CECT) for preoperative detection of liver metastasis (LM) and reduction of open-close laparotomies for panc...

Authors: Kartik S. Jhaveri, Ali Babaei Jandaghi, Seng Thipphavong, Osvaldo Espin-Garcia, Anna Dodd, Shawn Hutchinson, Trevor W. Reichman, Carol-Anne Moulton, Ian D. McGilvary and Steven Gallinger

Integrin α_vβ₆-targeted MR molecular imaging of breast cancer in a xenograft mouse model

The motif RXDLXXL-based nanoprobes allow specific imaging of integrin α_vβ₆, a protein overexpressed during tumorigenesis and tumor progression of various tumors. We applied a novel RXDLXXL-coupled cyclic arginine...

Authors: Dengfeng Li, Chengyan Dong, Xiaohong Ma and Xinming Zhao

Deep learning for semi-automated unidirectional measurement of lung tumor size in CT

Performing Response Evaluation Criteria in Solid Tumor (RECISTS) measurement is a non-trivial task requiring much expertise and time. A deep learning-based algorithm has the potential to assist with rapid and ...

Authors: MinJae Woo, A. Michael Devane, Steven C. Lowe, Ervin L Lowther and Ronald W. Gimbel

CT-based multi-phase Radiomic models for differentiating clear cell renal cell carcinoma

The aim of the study is to compare the diagnostic value of models that based on a set of CT texture and non-texture features for differentiating clear cell renal cell carcinomas(ccRCCs) from non-clear cell ren...

Authors: Menglin Chen, Fu Yin, Yuanmeng Yu, Haijie Zhang and Ge Wen

Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study

This study aimed to explore the spatial distribution of brain metastases (BMs) from small cell lung cancer (SCLC) a homogenous sample, and to identify the metastatic risk levels in brain regions.

Authors: Yong Wang, Wei Xia, Baoyan Liu, Liu Zhou, Meng Ni, Rui Zhang, Jingyi Shen, Yujun Bai, Guixiang Weng, Shuanghu Yuan and Xin Gao

High resolution MRI-based radiomic nomogram in predicting perineural invasion in rectal cancer

To establish and validate a high-resolution magnetic resonance imaging (HRMRI)-based radiomic nomogram for prediction of preoperative perineural invasion (PNI) of rectal cancer (RC).

Authors: Yan-song Yang, Yong-juan Qiu, Gui-hua Zheng, Hai-peng Gong, Ya-qiong Ge, Yi-fei Zhang, Feng Feng and Yue-tao Wang

Primary disease sites and patterns of spread in cases of neurolymphomatosis in the orbit associated with lymphoma

Neurolymphomatosis involving the cranial nerves (CNs) is rare. We sought a better understanding of the primary disease sites and patterns of spread in neurolymphomatosis of the orbit and retro-orbital cranial ...

Authors: Seth J. Fritzhand, Bita Esmaeli, Jia Sun and J. Matthew Debnam

Application of contrast-enhanced CT radiomics in prediction of early recurrence of locally advanced oesophageal squamous cell carcinoma after trimodal therapy

Early recurrence of oesophageal squamous cell carcinoma (SCC) is defined as recurrence after surgery within 1 year, and appears as local recurrence, distant recurrence, and lymph node positive and disseminated...

Authors: Sun Tang, Jing Ou, Jun Liu, Yu-ping Wu, Chang-qiang Wu, Tian-wu Chen, Xiao-ming Zhang, Rui Li, Meng-jie Tang, Li-qin Yang, Bang-guo Tan, Fu-lin Lu and Jiani Hu

“Real-world” radiomics from multi-vendor MRI: an original retrospective study on the prediction of nodal status and disease survival in breast cancer, as an exemplar to promote discussion of the wider issues

Most MRI radiomics studies to date, even multi-centre ones, have used “pure” datasets deliberately accrued from single-vendor, single-field-strength scanners. This does not reflect aspirations for the ultimate...

Authors: Simon J. Doran, Santosh Kumar, Matthew Orton, James d’Arcy, Fenna Kwaks, Elizabeth O’Flynn, Zaki Ahmed, Kate Downey, Mitch Dowsett, Nicholas Turner, Christina Messiou and Dow-Mu Koh

The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review

Diagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several ...

Authors: Stefanie Slot, Niels W. C. J. van de Donk, René H. J. Otten, Bouke J. H. Boden, Josée Zijlstra, Pieter G. H. M. Raijmakers and Sonja Zweegman

Intra-patient comparison of physiologic ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing ⁶⁸Ga -PSMA-11 and in 96.9% of patients undergoing ¹⁸F-DCFPyL PET/CT examination. We have observed ...

Authors: Medhat M. Osman, Amir Iravani, Michael S. Hofman and Rodney J. Hicks

Validation of ¹⁸F-FDG PET/MRI and diffusion-weighted MRI for estimating the extent of peritoneal carcinomatosis in ovarian and endometrial cancer -a pilot study

The extent of peritoneal carcinomatosis is difficult to estimate preoperatively, but a valid measure would be important in identifying operable patients.

Authors: Björg Jónsdóttir, Montserrat Alemany Ripoll, Antonina Bergman, Ilvars Silins, Inger Sundström Poromaa, Håkan Ahlström and Karin Stålberg

Ultrasound features of medullary thyroid cancer as predictors of biological behavior

Medullary thyroid cancer (MTC) has more aggressive behavior and poor prognosis. Ultrasound (US) has facilitated the qualitative diagnosis of thyroid nodules, however, some MTC may be diagnosed as a benign nodu...

Authors: Jingzhu Zhao, Xiangqian Zheng, Ming Gao, Sheng Zhang, Xinwei Yun, Jiadong Chi and Guangwei Xu

Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization

To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer.

Authors: Jianxing Qiu, Jing Liu, Zhongxu Bi, Xiaowei Sun, Xin Wang, Junling Zhang, Chengwen Liu, Jinxia Zhu and Naishan Qin

Are radiomics features universally applicable to different organs?

Many studies have successfully identified radiomics features reflecting macroscale tumor features and tumor microenvironment for various organs. There is an increased interest in applying these radiomics featu...

Authors: Seung-Hak Lee, Hwan-ho Cho, Junmo Kwon, Ho Yun Lee and Hyunjin Park

Application of diffusion kurtosis tensor MR imaging in characterization of renal cell carcinomas with different pathological types and grades

To probe the feasibility and reproducibility of diffusion kurtosis tensor imaging (DKTI) in renal cell carcinoma (RCC) and to apply DKTI in distinguishing the subtypes of RCC and the grades of clear cell RCC (...

Authors: Jie Zhu, Xiaojie Luo, Jiayin Gao, Saying Li, Chunmei Li and Min Chen

Value of conventional magnetic resonance imaging texture analysis in the differential diagnosis of benign and borderline/malignant phyllodes tumors of the breast

The purpose of this study was to determine the potential value of magnetic resonance imaging (MRI) texture analysis (TA) in differentiating between benign and borderline/malignant phyllodes tumors of the breast.

Authors: Xiaoguang Li, Nianping Jiang, Chunlai Zhang, Xiangguo Luo, Peng Zhong and Jingqin Fang

The value of contrast‐enhanced ultrasound in determining the location of sentinel lymph nodes in breast cancer

This study aimed to explore the sentinel lymph node (SLN) identification rate in breast cancer by subcutaneous and intradermal injection of ultrasound contrast agent in the mammary areola region, compared to t...

Authors: Jun Luo, Liting Feng, Qing Zhou, Qin Chen, Jinping Liu, Chihua Wu, Jing Luo, Jie Chen, Hao Wu and Wanyue Deng

Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET

The purpose of this study was to develop a voxel-wise clustering method of multiparametric magnetic resonance imaging (MRI) and 3,4-dihydroxy-6-[¹⁸F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (P...

Authors: Hiroyuki Tatekawa, Akifumi Hagiwara, Hiroyuki Uetani, Shadfar Bahri, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon and Benjamin M. Ellingson

Radiomic nomogram based on MRI to predict grade of branching type intraductal papillary mucinous neoplasms of the pancreas: a multicenter study

Accurate diagnosis of high-grade branching type intraductal papillary mucinous neoplasms (BD-IPMNs) is challenging in clinical setting. We aimed to construct and validate a nomogram combining clinical characte...

Authors: Sijia Cui, Tianyu Tang, Qiuming Su, Yajie Wang, Zhenyu Shu, Wei Yang and Xiangyang Gong

Clinical utility of FDG PET/CT for primary and recurrent papillary renal cell carcinoma

Papillary renal cell carcinoma (RCC) is the second most common subtype of RCC, after clear cell RCC. This study aimed to investigate the usefulness of FDG PET/CT in primary and recurrent papillary RCC, and the...

Authors: Guozhu Hou, Dachun Zhao, Yuanyuan Jiang, Zhaohui Zhu, Li Huo, Fang Li and Wuying Cheng

Imaging features of fumarate hydratase-deficient renal cell carcinomas: a retrospective study

Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a subtype of RCC that is increasingly recognized pathologically. The aim of this study was to evaluate the imaging features of FH-RCC on computed t...

Authors: Ines Nikolovski, Maria I. Carlo, Ying-Bei Chen and Hebert Alberto Vargas

MR imaging features of pancreatic schwannoma: a Chinese case series and a systematic review of 25 cases

There is a paucity of existing literature centering on the magnetic resonance (MR) imaging features of pancreatic schwannomas, due to the neoplasm’s nonspecific presentation and its rarity. We aimed to identif...

Authors: Zhenshan Shi, Dairong Cao, Qian Zhuang, Ruixiong You, Xiumei Li, Zhongmin Li, Yueming Li and Xinming Huang

Pentixafor PET/CT for imaging of chemokine receptor 4 expression in esophageal cancer – a first clinical approach

Expression of CXCR4, a chemokine (C-X-C motif) receptor that plays a central role in tumor growth and metastasis of circulating tumor cells, has been described in a variety of solid tumors. A high expression o...

Authors: Philipp Linde, Christian Baues, Simone Wegen, Maike Trommer, Alexander Quaas, Johannes Rosenbrock, Eren Celik, Simone Marnitz, Christiane J. Bruns, Thomas Fischer, Klaus Schomaecker, Hans-Juergen Wester, Alexander Drzezga, Lutz van Heek and Carsten Kobe

Correction to: Diffusion-weighted MRI improves response assessment after definitive radiotherapy in patients with NSCLC

An amendment to this paper has been published and can be accessed via the original article.

Authors: Philippe Jagoda, Jochen Fleckenstein, Mathias Sonnhoff, Günther Schneider, Christian Ruebe, Arno Buecker and Jonas Stroeder

A CT-based radiomics nomogram for distinguishing between benign and malignant bone tumours

We sought to evaluate the performance of a computed tomography (CT)-based radiomics nomogram we devised in distinguishing benign from malignant bone tumours.

Authors: Weikai Sun, Shunli Liu, Jia Guo, Song Liu, Dapeng Hao, Feng Hou, Hexiang Wang and Wenjian Xu

Robustness of magnetic resonance radiomic features to pixel size resampling and interpolation in patients with cervical cancer

Radiomics is a promising field in oncology imaging. However, the implementation of radiomics clinically has been limited because its robustness remains unclear. Previous CT and PET studies suggested that radio...

Authors: Shin-Hyung Park, Hyejin Lim, Bong Kyung Bae, Myong Hun Hahm, Gun Oh Chong, Shin Young Jeong and Jae-Chul Kim

The chemical tool-kit for molecular imaging with radionuclides in the age of targeted and immune therapy

Nuclear medicine has evolved over the last half-century from a functional imaging modality using a handful of radiopharmaceuticals, many of unknown structure and mechanism of action, into a modern speciality t...

Authors: Timothy H. Witney and Philip J. Blower

Texture analysis of iodine maps and conventional images for k-nearest neighbor classification of benign and metastatic lung nodules

The purpose of this study was to analyze if the use of texture analysis on spectral detector CT (SDCT)-derived iodine maps (IM) in addition to conventional images (CI) improves lung nodule differentiation, whe...

Authors: Simon Lennartz, Alina Mager, Nils Große Hokamp, Sebastian Schäfer, David Zopfs, David Maintz, Hans Christian Reinhardt, Roman K. Thomas, Liliana Caldeira and Thorsten Persigehl

Diagnostic efficiency of whole-body ¹⁸F-FDG PET/MRI, MRI alone, and SUV and ADC values in staging of primary uterine cervical cancer

The use of PET/MRI for gynecological cancers is emerging. The purpose of this study was to assess the additional diagnostic value of PET over MRI alone in local and whole-body staging of cervical cancer, and t...

Authors: Aida Steiner, Sara Narva, Irina Rinta-Kiikka, Sakari Hietanen, Johanna Hynninen and Johanna Virtanen

Diffusion-weighted MRI improves response assessment after definitive radiotherapy in patients with NSCLC

Computed tomography (CT) is the standard procedure for follow-up of non-small-cell lung cancer (NSCLC) after radiochemotherapy. CT has difficulties differentiating between tumor, atelectasis and radiation indu...

Authors: Philippe Jagoda, Jochen Fleckenstein, Mathias Sonnhoff, Günther Schneider, Christian Ruebe, Arno Buecker and Jonas Stroeder

Interstitial lung abnormalities in patients with stage I non-small cell lung cancer are associated with shorter overall survival: the Boston lung cancer study

Interstitial lung abnormalities (ILA) can be detected on computed tomography (CT) in lung cancer patients and have an association with mortality in advanced non-small cell lung cancer (NSCLC) patients. The aim...

Authors: Tomoyuki Hida, Akinori Hata, Junwei Lu, Vladimir I. Valtchinov, Takuya Hino, Mizuki Nishino, Hiroshi Honda, Noriyuki Tomiyama, David C. Christiani and Hiroto Hatabu

Assessment of tissue perfusion of pancreatic cancer as potential imaging biomarker by means of Intravoxel incoherent motion MRI and CT perfusion: correlation with histological microvessel density as ground truth

The aim of this study was to compare intravoxel incoherent motion (IVIM) diffusion weighted (DW) MRI and CT perfusion to assess tumor perfusion of pancreatic ductal adenocarcinoma (PDAC).

Authors: Philipp Mayer, Franziska Fritz, Marco Koell, Stephan Skornitzke, Frank Bergmann, Matthias M. Gaida, Thilo Hackert, Klaus Maier-Hein, Frederik B. Laun, Hans-Ulrich Kauczor, Lars Grenacher, Miriam Klauß and Wolfram Stiller

A comparative study of methods for determining Intravoxel incoherent motion parameters in cervix cancer

To compare different fitting methods for determining IVIM (Intravoxel Incoherent Motion) parameters and to determine whether the use of different IVIM fitting methods would affect differentiation of cervix can...

Authors: Xue Wang, Jiao Song, Shengfa Zhou, Yi Lu, Wenxiao Lin, Tong San Koh, Zujun Hou and Zhihan Yan

Value of ¹⁸F-FDG-PET to predict PD-L1 expression and outcomes of PD-1 inhibition therapy in human cancers

Anti-programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies are administered in varied human cancer types. The expression of PD-L1 within tumor cells has been identified as a predictive ma...

Authors: Kyoichi Kaira, Ichiei Kuji and Hiroshi Kagamu

Imaging of head and neck mucosa-associated lymphoid tissue lymphoma (MALToma)

Marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALToma) arises in extranodal sites in the head and neck. Chronic inflammatory, infectious or autoimmune conditions are implicated in its pat...

Authors: K. W. S. Ko, Kunwar S. Bhatia, Qi Yong H. Ai and Ann D. King

Nomograms based on SUVmax of ¹⁸F-FDG PET/CT and clinical parameters for predicting progression-free and overall survival in patients with newly diagnosed extranodal natural killer/T-cell lymphoma

The prognostic value of ¹⁸F-FDG PET/CT in extranodal natural killer/T-cell lymphoma (ENKTL) is not well established. We aimed to develop nomograms for individualized estimates of progression-free survival (PFS) a...

Authors: Hongyan Li, Guozhu Shao, Yajing Zhang, Xiaomin Chen, Chengcheng Du, Kun Wang and Zairong Gao

Relationship between clinicopathologic factors and FDG avidity in radioiodine-negative recurrent or metastatic differentiated thyroid carcinoma

In this study, we investigated the relationship between clinicopathologic factors, BRAF^V600E mutation status and [¹⁸F] F-fluoro-2-deoxyglucose (FDG) avidity in patients with radioiodine (RAI)-negative recurrent o...

Authors: Le Ngoc Ha, Amir Iravani, Nguyen Thi Nhung, Ngo Thi Minh Hanh, Febby Hutomo and Mai Hong Son