Articles

Automatic segmentation of head and neck primary tumors on MRI using a multi-view CNN

Accurate segmentation of head and neck squamous cell cancer (HNSCC) is important for radiotherapy treatment planning. Manual segmentation of these tumors is time-consuming and vulnerable to inconsistencies bet...

Authors: Jens P.E. Schouten, Samantha Noteboom, Roland M. Martens, Steven W. Mes, C. René Leemans, Pim de Graaf and Martijn D. Steenwijk

PET/MR fusion texture analysis for the clinical outcome prediction in soft-tissue sarcoma

Various fusion strategies (feature-level fusion, matrix-level fusion, and image-level fusion) were used to fuse PET and MR images, which might lead to different feature values and classification performance. T...

Authors: Wenzhe Zhao, Xin Huang, Geliang Wang and Jianxin Guo

Multidetector CT findings of primary pleural angiosarcoma : a systematic review, an additional cases report

To demonstrate and analyze the relatively common imaging findings in this rare primary pleural angiosarcoma (PPA).

Authors: Bo Mi Gil, Myung Hee Chung, Ki-Nam Lee, Jung Im Jung, Won Jong Yoo, Soon Seog Kwon and Heejeong Lee

Quantitative washout in patients with hepatocellular carcinoma undergoing TACE: an imaging biomarker for predicting prognosis?

The delayed percentage attenuation ratio (DPAR) was recently identified as a novel predictor of an early complete response in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoemboliza...

Authors: Lukas Müller, Felix Hahn, Florian Jungmann, Aline Mähringer-Kunz, Fabian Stoehr, Moritz C. Halfmann, Daniel Pinto dos Santos, Jan Hinrichs, Timo A. Auer, Christoph Düber and Roman Kloeckner

Radiomics nomogram for the preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma

To develop and validate a radiomics nomogram for the preoperative prediction of lymph node (LN) metastasis in pancreatic ductal adenocarcinoma (PDAC).

Authors: Yun Bian, Shiwei Guo, Hui Jiang, Suizhi Gao, Chengwei Shao, Kai Cao, Xu Fang, Jing Li, Li Wang, Chao Ma, Jianming Zheng, Gang Jin and Jianping Lu

PET/CT variants and pitfalls in malignant melanoma

¹⁸F-FDG PET/CT plays an increasingly pivotal role in the staging and post-treatment monitoring of high-risk melanoma patients, augmented by the introduction of therapies, including tyrosine kinase inhibitors (TK....

Authors: Nicolas Aide, Amir Iravani, Kevin Prigent, Diane Kottler, Ramin Alipour and Rodney J. Hicks

Long-term outcome of percutaneous radiofrequency ablation for periportal hepatocellular carcinoma: tumor recurrence or progression, survival and clinical significance

Recent studies have suggested that periportal location of percutaneous radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is considered as one of the independent risk factors for local tumor prog...

Authors: Shoujin Cao, Tianshi Lyu, Zeyang Fan, Haitao Guan, Li Song, Xiaoqiang Tong, Jian Wang and Yinghua Zou

Early tumor shrinkage and response assessment according to mRECIST predict overall survival in hepatocellular carcinoma patients under sorafenib

The aim of this study was to explore the relationship between follow-up imaging characteristics and overall survival (OS) in advanced hepatocellular carcinoma (HCC) patients under sorafenib treatment.

Authors: Osman Öcal, Regina Schinner, Kerstin Schütte, Enrico N. de Toni, Christian Loewe, Otto van Delden, Vincent Vandecaveye, Bernhard Gebauer, Christoph J. Zech, Christian Sengel, Irene Bargellini, Antonio Gasbarrini, Bruno Sangro, Maciej Pech, Peter Malfertheiner, Jens Ricke…

Free-breathing radial 3D fat-suppressed T1-weighted gradient echo (r-VIBE) sequence for assessment of pulmonary lesions: a prospective comparison of CT and MRI

To determine whether the pulmonary MR imaging with free-breathing radial 3D fat-suppressed T1-weighted gradient echo (r-VIBE) sequence can detect lung lesions and display lesion profiles with an accuracy compa...

Authors: Nan Yu, Haifeng Duan, Chuangbo Yang, Yong Yu and Shan Dang

DCE-MRI is more sensitive than IVIM-DWI for assessing anti-angiogenic treatment-induced changes in colorectal liver metastases

Diffusion weighted imaging (DWI) with intravoxel incoherent motion (IVIM) modelling can inform on tissue perfusion without exogenous contrast administration. Dynamic-contrast-enhanced (DCE) MRI can also charac...

Authors: Mihaela Rata, Khurum Khan, David J Collins, Dow-Mu Koh, Nina Tunariu, Maria Antonietta Bali, James d’Arcy, Jessica M Winfield, Simona Picchia, Nicola Valeri, Ian Chau, David Cunningham, Matteo Fassan, Martin O Leach and Matthew R Orton

Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers

The indication for endoscopic resection for submucosally invasive colorectal cancer (T1-CRC) depends on the preoperative diagnosis of invasion depth. The aim of this investigation was to evaluate the associati...

Authors: Keisuke Kawasaki, Takehiro Torisu, Takahisa Nagahata, Motohiro Esaki, Koichi Kurahara, Makoto Eizuka, Yoshihito Tanaka, Minako Fujiwara, Shinichiro Kawatoko, Yumi Oshiro, Shun Yamada, Koji Ikegami, Shin Fujioka, Yuta Fuyuno, Yuichi Matsuno, Junji Umeno…

Magnetic resonance imaging-based radiomics signature for preoperative prediction of Ki67 expression in bladder cancer

The Ki67 expression is associated with the advanced clinicopathological features and poor prognosis in bladder cancer (BCa). We aimed to develop and validate magnetic resonance imaging (MRI)-based radiomics si...

Authors: Zongtai Zheng, Zhuoran Gu, Feijia Xu, Niraj Maskey, Yanyan He, Yang Yan, Tianyuan Xu, Shenghua Liu and Xudong Yao

Whole-body diffusion-weighted MRI of normal lymph nodes: prospective apparent diffusion coefficient histogram and nodal distribution analysis in a healthy cohort

Whole body DWI (WB-DWI) enables the identification of lymph nodes for disease evaluation. However, quantitative data of benign lymph nodes across the body are lacking to allow meaningful comparison of diseased...

Authors: Ricardo Donners, Raphael Shih Zhu Yiin, Matthew Blackledge and Dow-Mu Koh

Radiology reporting in oncology—oncologists’ perspective

Structured reporting and standardized criteria are increasingly recognized as means of improving both radiological and clinical practice by allowing for better content and clarity. Our aim was to examine oncol...

Authors: Elisabeta Valeria Spînu-Popa, Dania Cioni and Emanuele Neri

Retraction Note to: Diffusion-weighted MR imaging of locally advanced breast carcinoma: the optimal time window of predicting the early response to neoadjuvant chemotherapy

Authors: Li Yuan, Jian-Jun Li, Chang-Qing Li, Cheng-Gong Yan, Ze-Long Cheng, Yuan-Kui Wu, Peng Hao, Bing-Quan Lin and Yi-Kai Xu

CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck

Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSC...

Authors: Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel and Joseph A. Paydarfar

Associations between dynamic-contrast enhanced MRI and tumor infiltrating lymphocytes and tumor-stroma ratio in head and neck squamous cell cancer

The present study used dynamic-contrast enhanced MRI (DCE-MRI) to elucidate possible associations with tumor-infiltrating lymphocytes (TIL), stroma ratio and vimentin expression in head and neck squamous cell ...

Authors: Hans-Jonas Meyer, Anne Kathrin Höhn and Alexey Surov

Comparison of the pre-treatment functional MRI metrics’ efficacy in predicting Locoregionally advanced nasopharyngeal carcinoma response to induction chemotherapy

Functional MRI (fMRI) parameters analysis has been proven to be a promising tool of predicting therapeutic response to induction chemotherapy (IC) in nasopharyngeal carcinoma (NPC). The study was designed to iden...

Authors: Da-wei Zhao, Wen-jun Fan, Ling-ling Meng, Yan-rong Luo, Jian Wei, Kun Liu, Gang Liu, Jin-feng Li, Xiao Zang, Meng Li, Xin-xin Zhang and Lin Ma

Magnetic resonance imaging of pure ovarian dysgerminoma: a series of eight cases

Imaging findings have a prominent role in early and correct identification of ovarian dysgerminoma, the most common ovarian malignant germ cell tumor (OMGCT). Despite Computed Tomography (CT) is widely used, M...

Authors: Laura Maria Cacioppa, Federico Crusco, Francesco Marchetti, Michele Duranti, Matteo Renzulli and Rita Golfieri

FDG-PET/CT imaging for evaluating durable responses to immune check point inhibitors in patients with advanced cutaneous squamous cell carcinoma

The role of FDG-PET/CT imaging in assessing response to immunotherapy in advanced cutaneous squamous cell carcinoma (CSCC) is unknown. This study compared complete metabolic response (CMR) rates by FDG-PET and...

Authors: Luke S. McLean, Karda Cavanagh, Rodney J. Hicks, Jason Callahan, Jing Xie, Anthony Cardin, Annette M. Lim and Danny Rischin

Predicting microvascular invasion in hepatocellular carcinoma: a deep learning model validated across hospitals

The accuracy of estimating microvascular invasion (MVI) preoperatively in hepatocellular carcinoma (HCC) by clinical observers is low. Most recent studies constructed MVI predictive models utilizing radiologic...

Authors: Shu-Cheng Liu, Jesyin Lai, Jhao-Yu Huang, Chia-Fong Cho, Pei Hua Lee, Min-Hsuan Lu, Chun-Chieh Yeh, Jiaxin Yu and Wei-Ching Lin

Clustering subtypes of breast cancer by combining immunohistochemistry profiles and metabolism characteristics measured using FDG PET/CT

The aim of this study was to investigate the effect of combining immunohistochemical profiles and metabolic information to characterize breast cancer subtypes.

Authors: Hyun Woo Kwon, Jeong Hyeon Lee, Kisoo Pahk, Kyong Hwa Park and Sungeun Kim

Differentiating prostate cancer from benign prostatic hyperplasia using whole-lesion histogram and texture analysis of diffusion- and T2-weighted imaging

To explore the usefulness of analyzing histograms and textures of apparent diffusion coefficient (ADC) maps and T2-weighted (T2W) images to differentiate prostatic cancer (PCa) from benign prostatic hyperplasi...

Authors: Pengyi Xing, Luguang Chen, Qingsong Yang, Tao Song, Chao Ma, Robert Grimm, Caixia Fu, Tiegong Wang, Wenjia Peng and Jianping Lu

Proceedings of the International Cancer Imaging Society Meeting and 20th Annual Teaching Course

Authors:

CT and MRI findings of cystic renal cell carcinoma: comparison with cystic collecting duct carcinoma

Cystic renal cell carcinoma (CRCC) and cystic collecting duct carcinoma (CCDC) share similar oncogeni and some imaging findings. The aim of this study was to characterize the clinical and CT imagings features ...

Authors: Qingqiang Zhu, Jun Ling, Jing Ye, Wenrong Zhu, Jingtao Wu and Wenxin Chen

Emergency room imaging in pediatric patients with cancer: analysis of the spectrum and frequency of imaging modalities and findings in a tertiary cancer center and their relationship with survival

To assess the spectrum and frequency of modalities used for emergency room (ER) imaging and their findings in pediatric cancer patients and assess their relationship with survival.

Authors: Sungmin Woo, Abdallah Araji, Mohammad Ali El Amine, Natalie Gangai, Elizabeth Acquafredda, Anita P. Price, Tanya M. Trippett, Hedvig Hricak, Hebert Alberto Vargas and Gerald G. Behr

Tumor stiffness measured by 3D magnetic resonance elastography can help predict the aggressiveness of endometrial carcinoma: preliminary findings

Preoperative evaluation of aggressiveness, including tumor histological subtype, grade of differentiation, Federation International of Gynecology and Obstetrics (FIGO) stage, and depth of myometrial invasion, ...

Authors: Linqi Zhang, Xi Long, Mayidili Nijiati, Tianhui Zhang, Mengsi Li, Ying Deng, Sichi Kuang, Yuanqiang Xiao, Jie Zhu, Bingjun He, Jingbiao Chen, Phillip Rossman, Kevin J Glaser, Sudhakar K Venkatesh, Richard L Ehman and Jin Wang

Applying arterial enhancement fraction (AEF) texture features to predict the tumor response in hepatocellular carcinoma (HCC) treated with Transarterial chemoembolization (TACE)

To evaluate the application of Arterial Enhancement Fraction (AEF) texture features in predicting the tumor response in Hepatocellular Carcinoma (HCC) treated with Transarterial Chemoembolization (TACE) by mea...

Authors: Xiaonan Mao, Yan Guo, Feng Wen, Hongyuan Liang, Wei Sun and Zaiming Lu

Implementing CT tumor volume and CT pleural thickness into future staging systems for malignant pleural mesothelioma

Tumor thickness and tumor volume measured by computed tomography (CT) were suggested as valuable prognosticator for patients’ survival diagnosed with malignant pleural mesothelioma (MPM). The purpose was to as...

Authors: Olivia Lauk, Miriam Patella, Thomas Neuer, Bianca Battilana, Thomas Frauenfelder, Thi Dan Linh Nguyen-Kim, Walter Weder, Claudio Caviezel, Sven Hillinger, Ilhan Inci and Isabelle Opitz

Differentiation of renal angiomyolipoma without visible fat from small clear cell renal cell carcinoma by using specific region of interest on contrast-enhanced CT: a new combination of quantitative tools

To investigate the value of using specific region of interest (ROI) on contrast-enhanced CT for differentiating renal angiomyolipoma without visible fat (AML.wovf) from small clear cell renal cell carcinoma (c...

Authors: Xu Wang, Ge Song and Haitao Jiang

MRI-based radiomics models to assess prostate cancer, extracapsular extension and positive surgical margins

To investigate the performance of magnetic resonance imaging (MRI)-based radiomics models for benign and malignant prostate lesion discrimination and extracapsular extension (ECE) and positive surgical margins...

Authors: Dong He, Ximing Wang, Chenchao Fu, Xuedong Wei, Jie Bao, Xuefu Ji, Honglin Bai, Wei Xia, Xin Gao, Yuhua Huang and Jianquan Hou

Can preoperative liver MRI with gadoxetic acid help reduce open-close laparotomies for curative intent pancreatic cancer surgery?

To evaluate gadoxetic acid-enhanced liver MRI (EOB-MRI) versus contrast-enhanced computed tomography (CECT) for preoperative detection of liver metastasis (LM) and reduction of open-close laparotomies for panc...

Authors: Kartik S. Jhaveri, Ali Babaei Jandaghi, Seng Thipphavong, Osvaldo Espin-Garcia, Anna Dodd, Shawn Hutchinson, Trevor W. Reichman, Carol-Anne Moulton, Ian D. McGilvary and Steven Gallinger

Integrin α_vβ₆-targeted MR molecular imaging of breast cancer in a xenograft mouse model

The motif RXDLXXL-based nanoprobes allow specific imaging of integrin α_vβ₆, a protein overexpressed during tumorigenesis and tumor progression of various tumors. We applied a novel RXDLXXL-coupled cyclic arginine...

Authors: Dengfeng Li, Chengyan Dong, Xiaohong Ma and Xinming Zhao

Deep learning for semi-automated unidirectional measurement of lung tumor size in CT

Performing Response Evaluation Criteria in Solid Tumor (RECISTS) measurement is a non-trivial task requiring much expertise and time. A deep learning-based algorithm has the potential to assist with rapid and ...

Authors: MinJae Woo, A. Michael Devane, Steven C. Lowe, Ervin L Lowther and Ronald W. Gimbel

CT-based multi-phase Radiomic models for differentiating clear cell renal cell carcinoma

The aim of the study is to compare the diagnostic value of models that based on a set of CT texture and non-texture features for differentiating clear cell renal cell carcinomas(ccRCCs) from non-clear cell ren...

Authors: Menglin Chen, Fu Yin, Yuanmeng Yu, Haijie Zhang and Ge Wen

Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study

This study aimed to explore the spatial distribution of brain metastases (BMs) from small cell lung cancer (SCLC) a homogenous sample, and to identify the metastatic risk levels in brain regions.

Authors: Yong Wang, Wei Xia, Baoyan Liu, Liu Zhou, Meng Ni, Rui Zhang, Jingyi Shen, Yujun Bai, Guixiang Weng, Shuanghu Yuan and Xin Gao

High resolution MRI-based radiomic nomogram in predicting perineural invasion in rectal cancer

To establish and validate a high-resolution magnetic resonance imaging (HRMRI)-based radiomic nomogram for prediction of preoperative perineural invasion (PNI) of rectal cancer (RC).

Authors: Yan-song Yang, Yong-juan Qiu, Gui-hua Zheng, Hai-peng Gong, Ya-qiong Ge, Yi-fei Zhang, Feng Feng and Yue-tao Wang

Primary disease sites and patterns of spread in cases of neurolymphomatosis in the orbit associated with lymphoma

Neurolymphomatosis involving the cranial nerves (CNs) is rare. We sought a better understanding of the primary disease sites and patterns of spread in neurolymphomatosis of the orbit and retro-orbital cranial ...

Authors: Seth J. Fritzhand, Bita Esmaeli, Jia Sun and J. Matthew Debnam

Application of contrast-enhanced CT radiomics in prediction of early recurrence of locally advanced oesophageal squamous cell carcinoma after trimodal therapy

Early recurrence of oesophageal squamous cell carcinoma (SCC) is defined as recurrence after surgery within 1 year, and appears as local recurrence, distant recurrence, and lymph node positive and disseminated...

Authors: Sun Tang, Jing Ou, Jun Liu, Yu-ping Wu, Chang-qiang Wu, Tian-wu Chen, Xiao-ming Zhang, Rui Li, Meng-jie Tang, Li-qin Yang, Bang-guo Tan, Fu-lin Lu and Jiani Hu

“Real-world” radiomics from multi-vendor MRI: an original retrospective study on the prediction of nodal status and disease survival in breast cancer, as an exemplar to promote discussion of the wider issues

Most MRI radiomics studies to date, even multi-centre ones, have used “pure” datasets deliberately accrued from single-vendor, single-field-strength scanners. This does not reflect aspirations for the ultimate...

Authors: Simon J. Doran, Santosh Kumar, Matthew Orton, James d’Arcy, Fenna Kwaks, Elizabeth O’Flynn, Zaki Ahmed, Kate Downey, Mitch Dowsett, Nicholas Turner, Christina Messiou and Dow-Mu Koh

The value of bone marrow, liver, and spleen imaging in diagnosis, prognostication, and follow-up monitoring of myeloproliferative neoplasms: a systematic review

Diagnostic and treatment response criteria for the JAK2/CALR/MPL mutation-related myeloproliferative neoplasms (MPNs) are largely based on bone marrow (BM) biopsy results. However, these biopsies have several ...

Authors: Stefanie Slot, Niels W. C. J. van de Donk, René H. J. Otten, Bouke J. H. Boden, Josée Zijlstra, Pieter G. H. M. Raijmakers and Sonja Zweegman

Intra-patient comparison of physiologic ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing ⁶⁸Ga -PSMA-11 and in 96.9% of patients undergoing ¹⁸F-DCFPyL PET/CT examination. We have observed ...

Authors: Medhat M. Osman, Amir Iravani, Michael S. Hofman and Rodney J. Hicks

Validation of ¹⁸F-FDG PET/MRI and diffusion-weighted MRI for estimating the extent of peritoneal carcinomatosis in ovarian and endometrial cancer -a pilot study

The extent of peritoneal carcinomatosis is difficult to estimate preoperatively, but a valid measure would be important in identifying operable patients.

Authors: Björg Jónsdóttir, Montserrat Alemany Ripoll, Antonina Bergman, Ilvars Silins, Inger Sundström Poromaa, Håkan Ahlström and Karin Stålberg

Ultrasound features of medullary thyroid cancer as predictors of biological behavior

Medullary thyroid cancer (MTC) has more aggressive behavior and poor prognosis. Ultrasound (US) has facilitated the qualitative diagnosis of thyroid nodules, however, some MTC may be diagnosed as a benign nodu...

Authors: Jingzhu Zhao, Xiangqian Zheng, Ming Gao, Sheng Zhang, Xinwei Yun, Jiadong Chi and Guangwei Xu

Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization

To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer.

Authors: Jianxing Qiu, Jing Liu, Zhongxu Bi, Xiaowei Sun, Xin Wang, Junling Zhang, Chengwen Liu, Jinxia Zhu and Naishan Qin

Are radiomics features universally applicable to different organs?

Many studies have successfully identified radiomics features reflecting macroscale tumor features and tumor microenvironment for various organs. There is an increased interest in applying these radiomics featu...

Authors: Seung-Hak Lee, Hwan-ho Cho, Junmo Kwon, Ho Yun Lee and Hyunjin Park

Application of diffusion kurtosis tensor MR imaging in characterization of renal cell carcinomas with different pathological types and grades

To probe the feasibility and reproducibility of diffusion kurtosis tensor imaging (DKTI) in renal cell carcinoma (RCC) and to apply DKTI in distinguishing the subtypes of RCC and the grades of clear cell RCC (...

Authors: Jie Zhu, Xiaojie Luo, Jiayin Gao, Saying Li, Chunmei Li and Min Chen

Value of conventional magnetic resonance imaging texture analysis in the differential diagnosis of benign and borderline/malignant phyllodes tumors of the breast

The purpose of this study was to determine the potential value of magnetic resonance imaging (MRI) texture analysis (TA) in differentiating between benign and borderline/malignant phyllodes tumors of the breast.

Authors: Xiaoguang Li, Nianping Jiang, Chunlai Zhang, Xiangguo Luo, Peng Zhong and Jingqin Fang

The value of contrast‐enhanced ultrasound in determining the location of sentinel lymph nodes in breast cancer

This study aimed to explore the sentinel lymph node (SLN) identification rate in breast cancer by subcutaneous and intradermal injection of ultrasound contrast agent in the mammary areola region, compared to t...

Authors: Jun Luo, Liting Feng, Qing Zhou, Qin Chen, Jinping Liu, Chihua Wu, Jing Luo, Jie Chen, Hao Wu and Wanyue Deng

Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET

The purpose of this study was to develop a voxel-wise clustering method of multiparametric magnetic resonance imaging (MRI) and 3,4-dihydroxy-6-[¹⁸F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (P...

Authors: Hiroyuki Tatekawa, Akifumi Hagiwara, Hiroyuki Uetani, Shadfar Bahri, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon and Benjamin M. Ellingson