Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation

The last 5 years have been marked by profound innovation in the targeted treatment of chronic lymphocytic leukemia (CLL) and indolent lymphomas. Using CLL as a case study, we present a timeline and overview of...

Authors: Babina Gosangi, Matthew Davids, Bhanusupriya Somarouthu, Francesco Alessandrino, Angela Giardino, Nikhil Ramaiya and Katherine Krajewski

Most-enhancing tumor volume by MRI radiomics predicts recurrence-free survival “early on” in neoadjuvant treatment of breast cancer

The hypothesis of this study was that MRI-based radiomics has the ability to predict recurrence-free survival “early on” in breast cancer neoadjuvant chemotherapy.

Authors: Karen Drukker, Hui Li, Natalia Antropova, Alexandra Edwards, John Papaioannou and Maryellen L. Giger

Ultrasound shear wave elastography of breast lesions: correlation of anisotropy with clinical and histopathological findings

Ultrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements may change with transducer orientation, defined as anisotropy. In this...

Authors: Ya-ling Chen, Yi Gao, Cai Chang, Fen Wang, Wei Zeng and Jia-jian Chen

Added value of diffusion-weighted imaging in hepatic tumors and its impact on patient management

To investigate the added diagnostic value of diffusion-weighted imaging (DWI) of the liver and its impact on therapy decisions in patients with hepatic malignancy.

Authors: Jana Taron, Jonas Johannink, Michael Bitzer, Konstantin Nikolaou, Mike Notohamiprodjo and Rüdiger Hoffmann

Imaging features of fibrolamellar hepatocellular carcinoma in gadoxetic acid-enhanced MRI

Fibrolamellar hepatocellular carcinoma (FLC) is a rare malignancy occurring in young patients without cirrhosis. Objectives of our study were to analyze contrast material uptake in hepatobiliary phase imaging ...

Authors: Viktoria Palm, Ruofan Sheng, Philipp Mayer, Karl-Heinz Weiss, Christoph Springfeld, Arianeb Mehrabi, Thomas Longerich, Anne Katrin Berger, Hans-Ulrich Kauczor and Tim Frederik Weber

Primary carcinosarcoma of the liver: imaging features and clinical findings in six cases and a review of the literature

Carcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of ima...

Authors: Jing Li, Pan Liang, Dandan Zhang, Jie Liu, Hongkai Zhang, Jinrong Qu and Jianbo Gao

MRI features of combined hepatocellular- cholangiocarcinoma versus mass forming intrahepatic cholangiocarcinoma

Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare primary liver tumor, which has overlapping imaging features with mass forming intra-hepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma ...

Authors: Jennifer Sammon, Sandra Fischer, Ravi Menezes, Hooman Hosseini-Nik, Sara Lewis, Bachir Taouli and Kartik Jhaveri

Pre-treatment DWI as a predictor of overall survival in locally advanced pancreatic cancer treated with Cyberknife radiotherapy and sequential S-1 therapy

To identify the value of the pre-treatment apparent diffusion coefficient (ADC) derived from diffusion weighted imaging (DWI) in predicting the overall survival (OS) for locally advanced pancreatic cancer (LAP...

Authors: Yu Zhang, Xiaofei Zhu, Denghui Liu, Jiaqi Song, Huojun Zhang and Jianping Lu

Cement pulmonary embolism as a complication of percutaneous vertebroplasty in cancer patients

Vertebroplasty is a minimally invasive procedure commonly performed for vertebral compression fractures secondary to osteoporosis or malignancy. Leakage of bone cement into the paravertebral venous system and ...

Authors: Asem Mansour, Nayef Abdel-Razeq, Hussein Abuali, Mohammad Makoseh, Nouran Shaikh-Salem, Kamelah Abushalha and Samer Salah

Diagnostic performance of ¹⁸F-FDG PET/CT using point spread function reconstruction on initial staging of rectal cancer: a comparison study with conventional PET/CT and pelvic MRI

Accurate staging is crucial for treatment selection and prognosis prediction in patients with rectal cancer. Point spread function (PSF) reconstruction can improve spatial resolution and signal-to-noise ratio ...

Authors: Masatoshi Hotta, Ryogo Minamimoto, Hideaki Yano, Yoshimasa Gohda and Yasutaka Shuno

Changes in biodistribution on ⁶⁸Ga-DOTA-Octreotate PET/CT after long acting somatostatin analogue therapy in neuroendocrine tumour patients may result in pseudoprogression

To evaluate the effects of long-acting somatostatin analogue (SSA) therapy on ⁶⁸Ga-DOTA-octreotate (GaTate) uptake at physiological and metastatic sites in neuroendocrine tumour (NET) patients.

Authors: Martin H. Cherk, Grace Kong, Rodney J. Hicks and Michael S. Hofman

¹⁸F–FDG-PET/CT and diffusion-weighted MRI for monitoring a BRAF and CDK 4/6 inhibitor combination therapy in a murine model of human melanoma

The purpose of the study was to investigate a novel BRAF and CDK 4/6 inhibitor combination therapy in a murine model of BRAF-V600-mutant human melanoma monitored by ¹⁸F–FDG-PET/CT and diffusion-weighted MRI (DW-M...

Authors: Ralf S. Eschbach, Philipp M. Kazmierczak, Maurice M. Heimer, Andrei Todica, Heidrun Hirner-Eppeneder, Moritz J. Schneider, Georg Keinrath, Olga Solyanik, Jessica Olivier, Wolfgang G. Kunz, Maximilian F. Reiser, Peter Bartenstein, Jens Ricke and Clemens C. Cyran

Identification of the pericardiacophrenic vein on CT

To evaluate the depictability of pericardiacophrenic veins (PCPV) as landmarks for the location of the phrenic nerves on multi-detector-row computed tomography (MDCT), and to investigate the usefulness of depi...

Authors: Yoshiyuki Ozawa, Ritsuko Suzuki, Masaki Hara and Yuta Shibamoto

⁶⁸Ga PSMA-11 PET with CT urography protocol in the initial staging and biochemical relapse of prostate cancer

⁶⁸Ga-labelled prostate specific membrane antigen (PSMA) ligand PET/CT is a promising modality in primary staging (PS) and biochemical relapse (BCR) of prostate cancer (PC). However, pe...

Authors: Amir Iravani, Michael S. Hofman, Tony Mulcahy, Scott Williams, Declan Murphy, Bimal K. Parameswaran and Rodney J. Hicks

Integration of CT urography improves diagnostic confidence of ⁶⁸Ga-PSMA-11 PET/CT in prostate cancer patients

To prove the feasibility of integrating CT urography (CTU) into ⁶⁸Ga-PSMA-11 PET/CT and to analyze the impact of CTU on assigning focal tracer accumulation in the ureteric space to either ureteric excretion or me...

Authors: Leon Will, Frederik L. Giesel, Martin T. Freitag, Anne K. Berger, Walter Mier, Klaus Kopka, Stefan A. Koerber, Hendrik Rathke, Christophe Kremer, Clemens Kratochwil, Hans-Ulrich Kauczor, Uwe Haberkorn and Tim F. Weber

3.0T MRI for long-term observation of lung nodules post cryoablation: a pilot study

The purpose of this study was to use serial magnetic resonance imaging (MRI) examinations to observe changes in malignant lung tumors over time post-cryoablation.

Authors: Jing Li, Jinrong Qu, Hongkai Zhang, Yingshu Wang, Lin Zheng, Xiang Geng, Yan Zhao and Hailiang Li

How we read pediatric PET/CT: indications and strategies for image acquisition, interpretation and reporting

PET/CT plays an important role in the diagnosis, staging and management of many pediatric malignancies. The techniques for performing PET/CT examinations in children have evolved, with increasing attention foc...

Authors: Gabrielle C. Colleran, Neha Kwatra, Leah Oberg, Frederick D. Grant, Laura Drubach, Michael J. Callahan, Robert D. MacDougall, Frederic H. Fahey and Stephan D. Voss

Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis

Malignant obstructive jaundice is a common problem in the clinic. Currently, the generally applied treatment methods are percutaneous transhepatic biliary drainage (PTBD) and endoscopic biliary drainage (EBD)....

Authors: Feng Duan, Li Cui, Yanhua Bai, Xiaohui Li, Jieyu Yan and Xuan Liu

Lymphomatosis cerebri: a rare variant of primary central nervous system lymphoma and MR imaging features

Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL), characterized by diffuse infiltration without the formation of a discrete mass. The diagnosis of LC is a challen...

Authors: Hui Yu, Bo Gao, Jing Liu, Yong-Cheng Yu, Mark S. Shiroishi, Ming-Ming Huang, Wen-Xiu Yang and Zhi-Zhong Guan

Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients

To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and ...

Authors: José Hugo Mendes Luz, Paula Mendes Luz, Tiago Bilhim, Henrique Salas Martin, Hugo Rodrigues Gouveia, Élia Coimbra, Filipe Veloso Gomes, Roberto Romulo Souza, Igor Murad Faria and Tiago Nepomuceno de Miranda

Proceedings of the International Cancer Imaging Society (ICIS) 17th Annual Teaching Course

Authors:

¹⁸F-FDG PET/CT response in a phase 1/2 trial of nab-paclitaxel plus gemcitabine for advanced pancreatic cancer

Positron emission tomography (PET) is poised to become a useful imaging modality in staging and evaluating therapeutic responses in patients with metastatic pancreatic cancer (mPC). This analysis from a phase ...

Authors: Ronald L. Korn, Daniel D. Von Hoff, Mitesh J. Borad, Markus F. Renschler, Desmond McGovern, R. Curtis Bay and Ramesh K. Ramanathan

Osteoradionecrosis of the hyoid bone after intra-arterial chemoradiotherapy for oropharyngeal cancer: MR imaging findings

Osteoradionecrosis (ORN) of the hyoid bone sometimes induces severe front neck infection and can cause laryngeal stenosis and carotid rupture. Although ORN of the hyoid bone is known to be a complication of ch...

Authors: Hiromitsu Hatakeyama, Noriyuki Fujima, Kazuhiko Tsuchiya, Kenji Mizoguchi, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma and Satoshi Fukuda

Subclinical focal cholangitis mimicking liver metastasis in asymptomatic patients with history of pancreatic ductal adenocarcinoma and biliary tree intervention

Cholangitis is an inflammatory process of the biliary tract with a wide range of clinical manifestations and it is not always considered in the differential diagnosis in asymptomatic patients. To the best of o...

Authors: Natally Horvat, Edmund M. Godfrey, Timothy J. Sadler, Jaclyn F. Hechtman, Laura H. Tang, Carlie S. Sigel, Serena Monti and Lorenzo Mannelli

Primary hepatic neuroendocrine tumors: multi-modal imaging features with pathological correlations

Primary hepatic neuroendocrine carcinomas (PHNECs) are rare and asymptomatic, and are therefore difficult to distinguish radiologically from other liver carcinomas. In this study, we aimed to determine the com...

Authors: Kai Yang, Ying-Sheng Cheng, Ji-Jin Yang, Xu Jiang and Ji-Xiang Guo