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Table 5 Prognostic factors for disease-free survival (DFS), univariate and multivariate analyses

From: Associations of muscle and adipose tissue parameters with long-term outcomes in middle and low rectal cancer: a retrospective cohort study

Prognostic factor

Univariate

Multivariate

HR (95% CI)

P

HR (95% CI)

P

Age (years)

1.008(0.984–1.033)

0.499

  

Sex

1.128(0.594–2.144)

0.712

  

BMI (kg/m2)

1.000(0.905–1.105)

0.998

  

CEA (ng/mL)

0.980(0.946–1.015)

0.256

  

TNM stage

 

0.905

  

I

Reference

Reference

  

II

0.821(0.335–2.007)

0.665

  

III

1.073(0.472–2.435)

0.867

  

IV

0.932(0.198–4.391)

0.929

  

Complications

 

0.076*

 

0.074

None

Reference

Reference

Reference

Reference

Minor

2.190(1.116–4.297)

0.023

2.220(1.131–4.359)

0.020

Major

1.574(0.684–3.621)

0.289

1.478(0.641–3.406)

0.359

ASA grade

 

0.699

  

1

Reference

Reference

  

2

0.782(0.411–1.491)

0.456

  

3

0.731(0.273–1.959)

0.533

  

Per-op CCRTx

0.934(0.415–2.104)

0.870

  

Post-op CCRTx

1.036(0.565–1.899)

0.909

  

Low-VFA vs high-VFA

1.095(0.598–2.007)

0.769

  

Low-MFA vs high-MFA

0.502(0.267–0.943)

0.032*

0.478(0.254–0.901)

0.022*

Low-SMI vs high-SMI

1.151(0.628–2.110)

0.649

  

Low-SMD vs high-SMD

2.248(1.195–4.228)

0.012*

2.280(1.211–4.291)

0.011*

  1. *Significant P values
  2. For risk factors with more than 2 categories, the first category was considered as the reference group
  3. ASA American Society of Anesthesiologists, BMI body mass index, CCRTx chemoradiation therapy, CEA carcinoembryonic antigen, MFA area of mesorectal fat, SMD skeletal muscle radiodensity, SMI skeletal muscle index, TNM tumor-node-metastasis, VFA area of visceral fat