Figure 3

Patient 3, 53 year-old woman. a and b: CT demonstrates a mostly sclerotic lesion with small areas of lysis. c: The main part of the lesion is a chordoma, revealing the characteristic destructive nodular growth pattern of the tumor (H&E, obj 4). On higher power (d), cords and strands of tumors cells in an abundant myxoid background with mild atypia are seen (H&E, obj 20). e: a small area of BNCT is composed of sheets of adipocyte-like cells, without a nodular growth pattern or myxoid background (H&E, obj 20). The atypical areas (f and g) do not fulfill the criteria for BNCT or chordoma. f: micronodular growth pattern, no myxoid background (H&E, obj 4). Eosinophilic spindle cells with mild atypia (g).