- Multidisciplinary Symposium — Carcinoma of the Pancreas: Monday 15 October 2001, 15.30–Close
- Open Access
Carcinoma of the pancreas: detection and staging using CT and MRI
- Jay P. Heiken1
© International Cancer Imaging Society 2001
- Published: 5 May 2015
- Positive Predictive Value
- Pancreatic Carcinoma
- Superior Mesenteric Vein
- Portal Venous Invasion
- Vessel Circumference
Our ability to diagnose pancreatic carcinoma has improved substantially over the past 20 years, owing to major advances in pancreatic imaging, including the development of US, CT and MRI. Despite these advances, however, the prognosis of patients with pancreatic cancer remains dismal. The overall 5-year survival rate is only 3%, although the 5-year survival rate for patients who undergo pancreatic resection is reported to be approximately 20%[2–4]. Because of the very poor prognosis of patients with pancreatic carcinoma, many physicians take a nihilistic approach to its diagnosis and staging. It is important to keep in mind, however, that a large percentage of patients with pancreatic cancer who undergo laparotomy for possible curative resection are found to have unresectable disease. Thus, optimization of pre-operative imaging is important in order to reduce the percentage of patients who are unnecessarily subjected to laparotomy.
CT has become established as the primary initial imaging method for both detection and staging of suspected pancreatic carcinoma. Most studies have found that CT is highly reliable when it demonstrates features indicating that a tumor is unresectable[5,6]. The positive predictive value (PPV) of a diagnosis of unresectability with helical CT has ranged from 92% to 100%[7–11]. Helical CT is less reliable, however, for predicting that a tumor is resectable (PPV = 76–90%)[7–11]. Nevertheless, this represents a substantial improvement over prediction of resectability with conventional CT (PPV = 45–72%)[12–14]. Limitations of CT include: poor ability to demonstrate small hepatic or peritoneal metastases; inability to demonstrate microscopic lymph node metastases; and inability to differentiate inflammatory from neoplastic lymph node enlargement.
Optimized technique is essential to achieve the highest predictive values for resectability and unresectability. The CT data should be acquired helically using a rapid IV contrast medium injection rate (e.g. 4–5 ml/s)[15,16] and appropriate scan timing during the pancreatic parenchymal phase of enhancement[17,18]. Images should be acquired with thin collimation (< 3 mm) to optimize in-plane spatial resolution, and overlapping reconstructions are recommended for producing high quality multiplanar and 3-dimensional images when needed. Curved planar reformations through the pancreatic duct or peripancreatic vessels can be useful for displaying the imaging findings to the surgeon. Two-dimensional and 3-dimensional volume-rendered images of the peripancreatic vessels are not routinely necessary for staging but can provide useful information in some cases[20,21]. Such CT angiographic images can be useful in pre-operative planning, especially if variant celiac axis, hepatic artery or superior mesenteric artery anatomy is present.
State-of-the-art MRI using breath-hold imaging sequences, a phased-array torso coil and dynamic gadolinium enhancement is equivalent to CT for demonstrating small pancreatic carcinomas and providing accurate staging information. A recent study found dynamic gadolinium-enhanced MR imaging to be superior to dual-phase helical CT in the pre-operative assessment of resectability of pancreatic carcinoma. However, in that study, the helical CT imaging technique was not optimized. As with CT, the MR imaging technique must be optimized in order for MR to provide accurate pre-operative staging information. The limitations of MR imaging are similar to those of CT. A potential advantage of MR is its superior tissue contrast compared with CT. In addition, heavily T2-weighted pulse sequences can be used to perform MR cholangiopancreatography (MRCP)[23,24]. Although its spatial resolution is less than that of endoscopic retrograde cholangiopancreatography (ERCP), an advantage of MRCP over ERCP, in addition to its noninvasiveness, is its ability to demonstrate the portions of the pancreatic and bile ducts proximal to obstructions and high-grade strictures. In addition, MRCP is useful for the demonstration and evaluation of mucin-producing pancreatic tumors[25–27].
In the hands of some investigators, transabdominal color Doppler ultrasonography has been shown to have an accuracy similar to those of CT and angiography for diagnosing arterial and portal venous invasion by pancreatic carcinoma[28,29]. Nevertheless, ultrasonography continues to play a secondary role in the detection and staging of pancreatic carcinoma at most institutions. Endoscopic ultrasound (EUS) is also highly accurate for predicting portal venous invasion and is considered by some investigators to be the most accurate test for imaging pancreatic cancer. EUS is particularly useful for detecting small masses in the head and body of the pancreas and for directing transluminal biopsies of these masses. Limitations of EUS are that it is not widely available and that it provides inconsistent visualization of the pancreatic tail. FDG-PET may have a potential role in the diagnosis of pancreatic carcinoma in patients with an indeterminate pancreatic mass, but currently does not play a significant role in pancreatic carcinoma staging.
Although criteria for unresectability vary among surgeons, imaging features that generally indicate unresectability include vascular invasion, lymph node metastases beyond those in the immediate vicinity of the pancreas, and distant metastases. Metastases most commonly involve the liver or peritoneum.
Several recent studies have evaluated the accuracy of CT findings of vascular invasion (of the portal vein, superior mesenteric vein, superior mesenteric artery, celiac axis and hepatic artery) in predicting the resectability of pancreatic carcinoma[31–34]. In three of these studies[32–34] the proportion of the vessel circumference in contact with the tumor was assessed. All three studies found that when the tumor is not contiguous with the vessel (i.e. when an intervening fat plane is present), vascular invasion is almost never present. When the tumor is contiguous with less than one-quarter of the vessel circumference, it is resectable in the majority of cases, but when the tumor is contiguous with one-quarter to one-half the vessel circumference, it is unresectable in the majority of cases. It is in the group of patients in which the tumor contacts up to one-half the vessel circumference that EUS may be of value to better assess vascular invasion. Otherwise, surgical exploration is needed to determine resectability. Tumors contacting more than one-half the circumference of the vessel are nearly always unresectable. Another study assessed the contour of the tumor at its point of contact with the vessel as a predictor of resectability. Tumors that were inseparable from the vessel but had a convex contour with the vessel wall were resectable in 55% of cases (an additional 34% could be resected but required venous resection). Tumors that were inseparable from the vessel and had a concave contour with the vessel were resectable in only 7% of cases (an additional 40% could be resected but required venous resection). The proportion of vessel circumference involved by tumor is a more reliable predictor of resectability than the tumor contour at its point of contact with the vessel. Another sign of unresectability of adenocarcinoma of the head of the pancreas is a teardrop shape of the superior mesenteric vein (SMV), which represents either direct tumor infiltration of the vein or peritumoral fibrosis adherent to the vessel.
Assessment of the peripancreatic veins can also provide information regarding the likelihood of vascular invasion by pancreatic carcinoma. In patients with pancreatic carcinoma, dilatation of the posterior superior pancreaticoduodenal vein or the gastrocolic trunk is a sign of portal or superior mesenteric vein invasion[36–39]. However, a dilated gastrocolic trunk should not be used as an independent sign of surgical unresectability.
Our ability to detect and stage pancreatic carcinoma is currently better than it has ever been, and it is very likely that continued technological advances in CT and MR imaging will further improve our diagnostic and staging capabilities. Improvements in pre-operative staging will further minimize the number of patients with unresectable tumors who undergo needless laparotomy and may help in directing patients to appropriate nonoperative or combined operative and nonoperative forms of therapy, if improved treatment methods become available. Finally, imaging for early detection of pancreatic carcinoma may take on greater importance if genetic screening methods allow identification of individuals who are at high risk for developing this insidious and deadly disease.
- National Cancer Institute. Annual Cancer Statistics Review 1973–1988. NIH Publication No. 91-1789. Bethesda, MD: Department of Health and Human Services, 1991.Google Scholar
- Fernández-del Castillo C, Rattner DW, Warshaw AL. Standards for pancreatic resection in the 1990s. Arch Surg 1995; 130: 295–300.View ArticlePubMedGoogle Scholar
- Geer RJ, Brennan MF. Prognostic indicators for survival after resection of pancreatic adenocarcinoma. Am J Surg 1993; 165: 68–73.View ArticlePubMedGoogle Scholar
- Cameron JL, Crist DW, Sitzmann JV et al. Factors influencing survival after pancreatoduodenectomy for pancreatic cancer. Am J Surg 1991; 161: 120–5.View ArticlePubMedGoogle Scholar
- Andren-Sandberg A, Lindberg CG, Lundstedt C, Ihse I. Computed tomography and laparoscopy in the assessment of the patient with pancreatic cancer. J Am Coll Surg 1998; 186: 35–40.View ArticlePubMedGoogle Scholar
- Freeny PC, Traverso LW, Ryan JA. Diagnosis and staging of pancreatic adenocarcinoma with dynamic computed tomography. Am J Surg 1993; 165: 600–5.View ArticlePubMedGoogle Scholar
- Zeman RK, Cooper C, Zeiberg AS et al. TNM staging of pancreatic carcinoma using helical CT. Am J Radiol 1997; 169: 459–64.Google Scholar
- Diehl SJ, Lehmann KJ, Sadick M, Lachmann R, Georgi M. Pancreatic cancer: value of dual-phase helical CT in assessing resectability. Radiology 1998; 206: 373–8.View ArticlePubMedGoogle Scholar
- Sheridan MB, Ward J, Guthrie JA et al. Dynamic contrast-enhanced MR imaging and dual-phase helical CT in the preoperative assessment of suspected pancreatic cancer: a comparative study with receiver operating characteristic analysis. Am J Radiol 1999; 173: 583–90.Google Scholar
- Legmann P, Vignaux O, Dousset B et al. Pancreatic tumors: comparison of dual-phase helical CT and endoscopic sonography. Am J Radiol 1998; 170: 1315–22.Google Scholar
- Coley SC, Strickland NH, Walker JD, Williamson RCN. Spiral CT and the pre-operative assessment of pancreatic adenocarcinoma. Clin Radiol 1997; 52: 24–30.View ArticlePubMedGoogle Scholar
- Warshaw AL. Implications of peritoneal cytology for staging of early pancreatic cancer. Am J Surg 1991; 161: 26–30.View ArticlePubMedGoogle Scholar
- Freeny PC, Traverso LW, Ryan JA. Diagnosis and staging of pancreatic adenocarcinoma with dynamic computed tomography. Am J Surg 1993; 165: 600–6.View ArticlePubMedGoogle Scholar
- Andersen HB, Effersoe H, Tjalve E et al. CT for assessment of pancreatic and periampullary cancer. Acta Radiol 1993; 34: 569–72.View ArticlePubMedGoogle Scholar
- Tublin ME, Tessler FN, Cheng SL et al. Effect of injection rate of contrast medium on pancreatic and hepatic helical CT. Radiology 1999; 210: 97–101.View ArticlePubMedGoogle Scholar
- Kim T, Murakami T, Takahashi S, Okada A, Hori M, Narumi Y, Nakamura H. Pancreatic CT imaging: effects of different injection rates and doses of contrast material. Radiology 1999; 212: 219–25.View ArticlePubMedGoogle Scholar
- Lu DS, Vandantham S, Krasny RM et al. Two-phase helical CT for pancreatic tumors: pancreatic versus hepatic phase enhancement of tumor, pancreas, and vascular structures. Radiology 1996; 199: 697–701.View ArticlePubMedGoogle Scholar
- Boland GW, O’Malley ME, Saez M, Fernández-del-Castillo C, Warshaw AL, Mueller PR. Pancreatic-phase versus portal vein-phase helical CT of the pancreas: optimal temporal window for evaluation of pancreatic adenocarcinoma. Am J Radiol 1999; 172: 605–8.Google Scholar
- Nino-Murcia M, Jeffrey RB, Beaulieu CF, Li KCP, Rubin GD. Multidetector CT of the pancreas and bile duct system: value of curved planar reformations. Am J Radiol 2001; 176: 689–93.Google Scholar
- Raptopoulos V, Steer ML, Sheiman RG, Vrachliotis TG, Gougoutas CA, Movson JS. The use of helical CT and CT angiography to predict vascular involvement from pancreatic cancer: correlation with findings at surgery. Am J Radiol 1997; 168: 971–7.Google Scholar
- Baek SY, Sheafor DH, Keogan MT, DeLong DM, Nelson RC. Two-dimensional multiplanar and three-dimensional volume-rendered vascular CT in pancreatic carcinoma: interobserver agreement and comparison with standard helical techniques. Am J Radiol 2001; 176: 1467–3.Google Scholar
- Ichikawa T, Haradome H, Hachiya J et al. Pancreatic ductal adenocarcinoma: preoperative assessment with helical CT versus dynamic MR imaging. Radiology 1997; 202: 655–62.View ArticlePubMedGoogle Scholar
- Lamanto D, Pavone P, Laghi A et al. Magnetic resonance cholangiopancreatography in the diagnosis of biliopancreatic diseases. Am J Surg 1997; 174: 33–8.View ArticleGoogle Scholar
- Yamaguchi K, Chijiiwa K, Shimizu S, Yokohata K, Morisaki T, Tanaka M. Comparison of endoscopic retrograde and magnetic resonance cholangiopancreatography in the surgical diagnosis of pancreatic diseases. Am J Surg 1998; 175: 203–8.View ArticlePubMedGoogle Scholar
- Sugiyama M, Atomi Y, Hachiya J. Intraductal papillary tumors of the pancreas: evaluation with magnetic resonance cholangiopancreatography. Am J Gastroenterol 1998; 93: 156–9.View ArticlePubMedGoogle Scholar
- Onaya H, Itai Y, Niitsu M et al. Ductectatic mucinous cystic neoplasms of the pancreas: evaluation with MR cholangiopancreatography. Am J Radiol 1998; 171: 171–7.Google Scholar
- Koito K, Namieno T, Ichimura T et al. Mucin-producing pancreatic tumors: comparison of MR cholangiopancreatography with endoscopic retrograde cholangiopancreatography. Radiology 1998; 208: 231–7.View ArticlePubMedGoogle Scholar
- Tomiyama T, Ueno N, Tano S, Wada S, Kimura K. Assessment of arterial invasion in pancreatic cancer using color Doppler ultrasonography. Am J Gastroenterol 1996; 91: 1410–6.PubMedGoogle Scholar
- Ueno N, Tomiyama T, Tano S, Wada S, Miyata T. Color Doppler ultrasonography in the diagnosis of portal vein invasion in patients with pancreatic cancer. J Ultrasound Med 1997; 16: 825–30.PubMedGoogle Scholar
- Sugiyama M, Hagi H, Atomi Y, Saito M. Diagnosis of portal venous invasion by pancreatobiliary carcinoma: value of endoscopic ultrasonography. Abdom Imaging 1997; 22: 434–8.View ArticlePubMedGoogle Scholar
- Loyer EM, David CL, Dubrow RA, Charnsangave C. Vascular involvement in pancreatic adenocarcinoma: reassessment by thin-section CT. Abdom Imaging 1996; 21: 202–6.View ArticlePubMedGoogle Scholar
- Lu DSK, Reber HA, Krasny RM, Kadell BM, Sayre J. Local staging of pancreatic cancer: criteria for unresectability of major vessels as revealed by pancreatic-phase, thin-section helical CT. Am J Radiol 1997; 168: 1439–43.Google Scholar
- Furukawa H, Kosuge T, Mukai K et al. Helical computed tomography in the diagnosis of portal vein invasion by pancreatic head carcinoma. Arch Surg 1998; 133: 61–5.PubMedGoogle Scholar
- O’Malley ME, Boland GWL, Wood BJ, Fernández-del-Castillo C, Warshaw AL, Mueller PR. Adenocarcinoma of the head of the pancreas: determination of surgical unresectability with thin-section pancreatic-phase helical CT. Am J Radiol 1999; 173: 1513–8.Google Scholar
- Hough TJ, Raptopoulos V, Siewert B, Matthews JB. Teardrop superior mesenteric vein: CT sign for unresectable carcinoma of the pancreas. Am J Radiol 1999; 173: 1509–12.Google Scholar
- Mori H, Miyake H, Aikawa H et al. Dilated posterior superior pancreaticoduodenal vein: recognition with CT and clinical significance in patients with pancreaticobiliary carcinomas. Radiology 1991; 181: 793–800.View ArticlePubMedGoogle Scholar
- Mori H, McGrath FP, Malone DE, Stevenson GW. The gastrocolic trunk and its tributaries: CT evaluation. Radiology 1992; 182: 871–7.View ArticlePubMedGoogle Scholar
- Hommeyer SC, Freeny PC, Crabo LG. Carcinoma of the head of the pancreas: evaluation of the pancreaticoduodenal veins with dynamic CT — potential for improved accuracy in staging. Radiology 1995; 196: 233–8.View ArticlePubMedGoogle Scholar
- Yamada Y, Mori H, Kiyosue H, Matsumoto S, Hori Y, Maeda T. CT assessment of the inferior peripancreatic veins: clinical significance. Am J Radiol 2000; 174: 677–84.Google Scholar