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Table 2 Correlation analysis between FDG PET/CT imaging features and immunohistochemical results with p-value < 0.10

From: Relationship of FDG PET/CT imaging features with tumor immune microenvironment and prognosis in colorectal cancer: a retrospective study

CD4 + cell

Grade 0

Grade 1

Grade 2

P-value

 MTV (cm3)

20.25 (15.05–43.83)

16.99 (10.93–29.13)

11.60 (6.47–26.54)

0.023

 TLG (g)

161.05 (105.23–442.98)

118.10 (66.49–243.70)

90.96 (36.61–212.22)

0.028

CD163 + cell

Grade 0

Grade 1

Grade 2

 

 CoV SUV

0.25 (0.22–0.33)

0.24 (0.20–0.27)

0.23 (0.21–0.29)

0.068

 Entropy

4.02 (3.58–4.43)

4.26 (3.77–4.57)

4.57 (3.90–4.97)

0.015

 BM SUV

1.62 (1.44–1.87)

1.79 (1.54–2.18)

1.84 (1.74–2.15)

0.020

 BLR

0.77 (0.71–0.85)

0.81 (0.73–1.02)

0.87 (0.77–1.03)

0.067

IL-6

Grade 0

Grade 1

Grade 2

 

 Maximum SUV

12.38 (8.94–16.01)

12.21 (9.24–14.57)

13.35 (11.00–21.16)

0.097

 MTV (cm3)

16.08 (6.81–24.87)

14.70 (6.73–27.70)

21.65 (11.60–37.94)

0.089

 TLG (g)

101.89 (55.21–242.75)

100.98 (37.04–189.25)

161.17 (85.78–490.48)

0.028

 Mean SUV

6.60 (5.26–9.33)

6.88 (5.44–8.18)

7.82 (6.23–10.26)

0.078

 Median SUV

6.24 (5.15–8.90)

6.57 (5.17–8.22)

7.44 (6.09–10.13)

0.067

 Uniformity

0.068 (0.048–0.093)

0.062 (0.049–0.085)

0.050 (0.038–0.066)

0.029

 Spleen SUV

1.63 (1.49–1.89)

1.69 (1.55–1.88)

1.83 (1.62–2.01)

0.077

 SLR

0.78 (0.71–0.87)

0.80 (0.76–0.84)

0.83 (0.78–0.96)

0.052

MMP-11

Grade 0

Grade 1

Grade 2

 

 CoV SUV

0.24 (0.20–0.32)

0.25 (0.23–0.30)

0.22 (0.19–0.30)

0.066

  1. All values are expressed in median (interquartile range)
  2. BLR, bone marrow-to-liver uptake ratio; BM, bone marrow; CoV, coefficient of variation; IL-6, interleukin-6; MMP-11, matrix metalloproteinase-11; MTV, metabolic tumor volume; SLR, spleen-to-liver uptake ratio; SUV, standardized uptake value; TLG, total lesion glycolysis