Skip to main content

Table 2 Univariate and multivariate-adjusted association of splenic area and overall survival in the discovery and validation cohort

From: Preoperative splenic area as a prognostic biomarker of early-stage non-small cell lung cancer

Variable

Univariate analysis

 

Multivariate analysis (M1)1

 

Multivariate analysis (M2)2

HR (95% CI)

P value

 

HR (95% CI)

P value

 

HR (95% CI)

P value

Discovery cohort

        

All patients

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.32(1.08,1.61)

0.007

 

1.29(1.06,1.58)

0.01

 

1.32(1.08,1.63)

0.008

Male

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.30 (1.01,1.67)

0.045

 

1.29 (1.00,1.67)

0.048

 

1.47 (1.13,1.93)

0.004

Female

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.18 (0.86,1.63)

0.31

 

1.17 (0.85,1.61)

0.35

 

1.07 (0.77,1.50)

0.69

Validation cohort

        

All patients

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.59 (1.01,2.50)

0.045

 

1.79 (1.12,2.86)

0.02

 

1.84 (1.12,3.02)

0.02

Male

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.54 (0.88–2.68)

0.13

 

1.5 (0.86,2.62)

0.15

 

1.57 (0.86,2.86)

0.14

Female

        

Normal

Ref

  

Ref

  

Ref

 

Abnormal

1.67 (0.75,3.74)

0.21

 

3.67(1.34,10.04)

0.01

 

3.83 (1.12,13.18)

0.03

  1. Note:
  2. 1Multivariate analysis (M1) was adjusted for age (continuous)
  3. 2Multivariate analysis (M2) was adjusted for multivariate analysis (M1) plus smoking history, preoperative CEA, tumor location, surgical approach, tumor differentiation, histologic stage and histologic type, pleural invasion and adjuvant chemotherapy
Back to article page

Cancer Imaging

ISSN: 1470-7330

Contact us