Table 3 The AUC, optimal threshold, sensitivity, specificity, and accuracy for the ADC44.5msmean, ADC44.5ms5th, ADC44.5ms95th, ADC7.1msmean, ADC7.1ms5th, ADC7.1ms95th, cADCmean, cADC5th, cADC95th, rcADCmean, rcADC5th, and rcADC95th of the enhancing and peritumoral regions to differentiate primary central nervous system lymphomas from glioblastomas
Parameter | AUC (95% CI) | p-value | Threshold value | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
Enhancing region | ||||||
 ADC44.5msmean | 0.811 (0.713–0.887) |  < 0.01 | 1.052 (× 10–3 mm2/s) | 53.0 | 100 | 64.4 |
 ADC44.5ms5th | 0.881 (0.793–0.940) |  < 0.01 | 0.646 (× 10–3 mm2/s) | 71.2 | 95.2 | 77.0 |
 ADC44.5ms95th | 0.674 (0.565–0.771) |  < 0.01 | 1.325 (× 10–3 mm2/s) | 72.7 | 61.9 | 70.1 |
 ADC7.1msmean | 0.747 (0.643–0.835) |  < 0.01 | 1.238 (× 10–3 mm2/s) | 45.5 | 100 | 58.6 |
 ADC7.1ms5th | 0.803 (0.704–0.880) |  < 0.01 | 0.888 (× 10–3 mm2/s) | 53.0 | 100 | 64.4 |
 ADC7.1ms95th | 0.646 (0.537–0.746) | 0.02 | 1.636 (× 10–3 mm2/s) | 45.5 | 90.5 | 56.3 |
 cADCmean | 0.871 (0.782–0.933) |  < 0.01 | 0.174 (× 10–3 mm2/s) | 89.4 | 76.2 | 86.2 |
 cADC5th | 0.725 (0.619–0.815) |  < 0.01 | 0.081 (× 10–3 mm2/s) | 68.2 | 71.4 | 69.0 |
 cADC95th | 0.804 (0.705–0.881) |  < 0.01 | 0.263 (× 10–3 mm2/s) | 80.3 | 76.2 | 79.3 |
 rcADCmean | 0.920 (0.842–0.967) |  < 0.01 | 21.2 (%) | 95.5 | 81.0 | 92.0 |
 rcADC5th | 0.725 (0.619–0.816) |  < 0.01 | 6.85 (%) | 66.7 | 71.4 | 67.8 |
 rcADC95th | 0.884 (0.797–0.943) |  < 0.01 | 32.0 (%) | 84.8 | 85.7 | 85.1 |
Peritumoral region | ||||||
 ADC44.5msmean | 0.613 (0.503–0.716) | 0.11 | 1.347 (× 10–3 mm2/s) | 65.2 | 61.9 | 64.4 |
 ADC44.5ms5th | 0.615 (0.505–0.718) | 0.08 | 0.907 (× 10–3 mm2/s) | 54.5 | 76.2 | 59.8 |
 ADC44.5ms95th | 0.622 (0.512–0.724) | 0.10 | 1.596 (× 10–3 mm2/s) | 56.1 | 71.4 | 59.8 |
 ADC7.1msmean | 0.635 (0.525–0.736) | 0.06 | 1.445 (× 10–3 mm2/s) | 66.7 | 66.7 | 66.7 |
 ADC7.1ms5th | 0.630 (0.520–0.731) | 0.05 | 0.969 (× 10–3 mm2/s) | 47.0 | 85.7 | 56.3 |
 ADC7.1ms95th | 0.633 (0.523–0.734) | 0.08 | 1.684 (× 10–3 mm2/s) | 56.1 | 71.4 | 59.8 |
 cADCmean | 0.547 (0.437–0.654) | 0.55 | 0.082 (× 10–3 mm2/s) | 53.0 | 66.7 | 56.3 |
 cADC5th | 0.504 (0.395–0.613) | 0.95 | 0.007 (× 10–3 mm2/s) | 30.3 | 81.0 | 42.5 |
 cADC95th | 0.539 (0.428–0.646) | 0.60 | 0.128 (× 10–3 mm2/s) | 43.9 | 71.4 | 50.6 |
 rcADCmean | 0.514 (0.405–0.623) | 0.85 | 7.35 (%) | 59.1 | 57.1 | 58.6 |
 rcADC5th | 0.504 (0.395–0.613) | 0.95 | 0.75 (%) | 66.7 | 19.0 | 55.2 |
 rcADC95th | 0.509 (0.399–0.618) | 0.90 | 27.6 (%) | 81.8 | 4.8 | 63.2 |