Table 4 Univariate analysis of clinical factors and PET/MRI biological imaging markers in relation to overall survival and progression-free survival in patients with esophageal squamous cell carcinoma
Variable | OS | PFS | ||
|---|---|---|---|---|
Patient no. (event no.) | P value | Patient no. (event no.) | P value | |
Age (years) | 0.576 | 0.201 | ||
≤ 56 | 21 (7) | 21 (12) | ||
> 56 | 19 (7) | 19 (7) | ||
Sex | 0.170 | 0.423 | ||
Male | 38 (12) | 38 (17) | ||
Female | 2 (2) | 2 (2) | ||
Tumor site | 0.710 | 0.969 | ||
Cervical | 3 (2) | 3 (1) | ||
Upper-third thoracic | 9 (4) | 9 (5) | ||
Middle-third thoracic | 17 (5) | 17 (8) | ||
Lower-third thoracic | 11 (3) | 11 (5) | ||
Tumor stage | 0.368 | 0.375 | ||
I-II | 5 (1) | 5 (1) | ||
III-IV | 35 (13) | 35 (18) | ||
T classification | 0.189 | 0.346 | ||
T1-2 | 7 (1) | 7 (2) | ||
T3-4 | 33 (13) | 33 (17) | ||
N classification | 0.516 | 0.770 | ||
N0-1 | 14 (4) | 14 (7) | ||
N2-3 | 26 (10) | 26 (12) | ||
Treatment | 0.144 | 0.025 | ||
nCRT + sugery | 13 (3) | 13 (3) | ||
dCRT | 27 (11) | 27 (16) | ||
Imaging Biomarker | ||||
Baseline SUVmax | 0.523 | 0.027 | ||
≤ 20 | 32 (12) | 32 (13) | ||
> 20 | 8 (2) | 8 (6) | ||
Baseline TLG (g/mL × mL) | 0.246 | 0.036 | ||
≤ 221.8 | 24 (8) | 24 (8) | ||
> 221.8 | 16 (6) | 16 (11) | ||
Baseline Ktrans (10− 3 min− 1) | 0.306 | 0.008 | ||
≤ 85.5 | 21 (7) | 21 (6) | ||
> 85.5 | 19 (7) | 19 (13) | ||
Baseline Kep (10− 3 min− 1) | 0.324 | 0.166 | ||
≤ 47 | 13 (4) | 13 (4) | ||
> 47 | 27 (10) | 27 (15) | ||
Baseline Ve (10− 3) | 0.088 | 0.004 | ||
≤ 202 | 31 (9) | 31 (12) | ||
> 202 | 9 (5) | 9 (7) | ||
Baseline iAUC | 0.190 | 0.921 | ||
≤ 235 | 9 (5) | 9 (4) | ||
> 235 | 31 (9) | 31 (15) | ||
Baseline ADCmean (10− 3 mm2/s) | 0.900 | 0.865 | ||
≤ 864 | 16 (4) | 16 (8) | ||
> 864 | 24 (10) | 24 (11) | ||
Interim SUVmax | 0.004 | 0.027 | ||
≤ 8.4 | 16 (2) | 16 (4) | ||
> 8.4 | 24 (12) | 24 (15) | ||
Interim TLG (g/mL × mL) | < 0.001 | < 0.001 | ||
≤ 98.9 | 29 (6) | 29 (8) | ||
> 98.9 | 11 (8) | 11 (11) | ||
Interim Ktrans (10− 3 min− 1) | 0.147 | 0.940 | ||
≤ 120.5 | 21 (10) | 21 (10) | ||
> 120.5 | 19 (4) | 19 (9) | ||
Interim Kep (10− 3 min− 1) | 0.304 | 0.426 | ||
≤ 159 | 35 (12) | 35 (16) | ||
> 159 | 5 (2) | 5 (3) | ||
Interim Ve (10− 3) | 0.015 | 0.455 | ||
≤ 89 | 9 (6) | 9 (5) | ||
> 89 | 31 (8) | 31 (14) | ||
Interim iAUC | 0.434 | 0.631 | ||
≤ 235 | 9 (4) | 9 (5) | ||
> 235 | 31(10) | 31 (14) | ||
Interim ADCmean (10− 3 mm2/s) | 0.105 | 0.568 | ||
≤ 1251 | 21 (9) | 21 (11) | ||
> 1251 | 19 (5) | 19 (8) | ||
Δ SUVmax | 0.006 | 0.047 | ||
≤ -48.6 (-32) | 16 (2) | 30 (12) | ||
> -48.6 (-32) | 24 (12) | 10 (7) | ||
Δ TLG (g/mL × mL) | 0.057 | 0.435 | ||
≤ -47.9 | 27 (7) | 27 (12) | ||
> -47.9 | 13 (7) | 13 (7) | ||
Δ Ktrans (10− 3 min− 1) | 0.235 | 0.046 | ||
≤ 21.2 | 21 (9) | 21 (13) | ||
> 21.2 | 19 (5) | 19 (6) | ||
Δ Kep (10− 3 min− 1) | 0.591 | 0.082 | ||
≤ 8.6 | 23 (9) | 23 (14) | ||
> 8.6 | 17 (5) | 17 (5) | ||
Δ Ve (10− 3) | 0.062 | 0.116 | ||
≤ -44 | 10 (6) | 10 (6) | ||
> -44 | 30 (8) | 30 (13) | ||
Δ iAUC | 0.372 | 0.367 | ||
≤ 1.7 | 17 (5) | 17 (7) | ||
> 1.7 | 23 (9) | 23 (12) | ||
Δ ADCmean (10− 3 mm2/s) | 0.217 | 0.752 | ||
≤ 6.3 | 24 (10) | 24 (10) | ||
> 6.3 | 16 (4) | 16 (9) | ||