Baseline and interim [18F]FDG-PET/MRI to assess treatment response and survival in patients with M0 esophageal squamous cell carcinoma treated by curative-intent therapy

Table 3 Comparison of PET/MRI parameters between the CR and non-CR groups

PET/MRI parameters	CR group median ± IQR	Non-CR group median ± IQR	P value
Baseline K^trans	83.960 ± 29.225	138.400 ± 122.100	0.087
Interim K^trans	125.580 ± 68.690	120.510 ± 37.665	0.520
ΔK ^trans	54.774 ± 94.165	-13.377 ± 36.951	0.359
Baseline K_ep	71.330 ± 53.925	104.640 ± 64.240	0.265
Interim K_ep	68.310 ± 54.088	90.560 ± 62.265	0.232
ΔK _ep	-6.824 ± 52.085	-0.846 ± 36.123	0.626
Baseline V_e	192.990 ± 59.943	269.180 ± 87.690	0.315
Interim V_e	232.580 ± 75.310	211.860 ± 56.485	0.607
ΔV _e	3.114 ± 47.243	-5.304 ± 23.312	0.386
Baseline iAUC	415.710 ± 145.535	551.010 ± 123.675	0.705
Interim iAUC	466.790 ± 224.903	642.550 ± 174.445	0.107
ΔiAUC	10.601 ± 74.505	33.293 ± 23.762	0.265
Baseline ADC_mean	1193.450 ± 610.553	1060.280 ± 510.645	0.665
Interim ADC_mean	1251.010 ± 606.508	1072.120 ± 553.610	0.551
ΔADC_mean	-0.229 ± 14.129	5.828 ± 6.820	0.978
Baseline SUVmax	15.150 ± 2.638	18.500 ± 3.340	0.062
Interim SUVmax	8.390 ± 2.620	10.620 ± 1.720	0.042
ΔSUVmax	-48.636 ± 11.937	-36.307 ± 10.398	0.302
Baseline TLG	146.230 ± 91.748	290.430 ± 72.225	0.013
Interim TLG	30.820 ± 25.108	98.910 ± 38.750	< 0.001
ΔTLG	-71.546 ± 16.773	-53.436 ± 16.810	0.464

IQR = interquartile range; CR = complete response; SUV_max = maximum standardized uptake value; TLG = total lesion glycolysis; ADC_mean = mean apparent diffusion coefficient; K^trans = volume transfer constant; K_ep = flux rate constant; V_e = extracellular volume ratio; iAUC = initial area under curve
P value, comparison of the parameters between CR group and non-CR group

ISSN: 1470-7330