Fig. 2

A combination of PET and MRI functional biomarkers in predicting overall survival. (A–D) Representative axial images of a lower-third esophageal cancer patient with T3N2 disease. (A) Interim maximal intensity projection PET image; (B) Interim contrast-enhanced MR image; (C) Fused interim [18F]FDG-PET/MRI image; and (D) Interim contrast-enhanced MR image with an overlaid Ve map of the primary tumor. This patient had an interim TLG of 113 and an interim Ve value of 34. He died of tumor recurrence with a short overall survival period of 8 months after definitive chemoradiotherapy. (E–H) Images of an upper-third esophageal carcinoma patient with T4bN2 disease. (E) Interim maximal intensity projection PET image; (F) Interim contrast-enhanced MR image; (G) Fused interim [18F]FDG-PET/MRI image; and (H) Interim contrast-enhanced MR image with an overlaid Ve map of the primary tumor. He had an interim TLG of 45 and a Ve value of 162. This patient still survived without disease recurrence for four years after definitive chemoradiotherapy