Fig. 5

The perineural outflow pathway in Control and GBM rats. Red arrows point to the optic nerves. CE-MRI in representative Control (A) and GBM (B) rats show the dynamics of contrast agent in the perineural spaces along the optic nerves before infusion, 15 min, 30 min, 90 min, 3 hours, and 5 hours after the infusion of Gd-DTPA in the cisterna magna. These images suggest compromised outflow of CSF tracer from the perineural spaces along the optic nerves in GBM rat