Fig. 2

Dynamic tracer concentration changes in Control and GBM representative rats. A Visualization of key anatomical structures in the rat brain including the olfactory bulb, pituitary recess, pineal recess, ICM infusion site, and relevant arterial segments including the olfactory artery, lateral orbitofrontal artery, azygos of the anterior cerebral artery (azACA), and internal frontal artery (IFA). B, C shows the time evolution of contrast agent in control (B) and GBM (C) rats using CE-MRI, demonstrating influx (0-30 min) and anatomical glymphatic enhancement 90 min, 3 hours, and 5 hours after ICM infusion of Gd-DTPA