Fig. 1

A T2WI shows the location of the tumor at 2.5 mm depth, 1.5 mm to the right, and 1.0 mm anterior to the bregma on the right hemisphere of the coronal section of the rat brain. The red dashed line encloses the whole tumor. Regions of interest (ROIs) for the olfactory bulb and whole brain are shown as colored anatomical areas in (B, C) on the sagittal sections of the rat brain. The time signal curves (TSCs) (D, E) are acquired from the related ROIs. Compared to the control rats, the TSCs measured from the GBM rats show an initial signal increase at later time points, a lower percentage of signal change from the baseline, and a slow signal decrease after the peak signal