Fig. 4
Representative Cases of 3D Response Utility in Predicting Overall Survival
A. Baseline scan (a, b) shows two target lesions of 5 and 9 mm. There were also other multiple lesions of less than 5 mm that are not shown in the image. On the MRI at best overall response (BOR) date (d, e), the previous target lesions show no significant change in size, and other multiple enhancing lesions measuring 1–2 mm have appeared (not shown in the image). Volumetric analysis of all segmented measurable and non-measurable enhancing lesions at baseline and the BOR date is shown in (c) and (f). On the baseline date (c), the total volume was 1459.1 mm3, and the total number of lesions was 35. On the BOR date (f), the total volume increased by 81.2% to 2643.4 mm3, and the measured number of lesions was 60. The patient died about 10 months after the baseline date B. Baseline scan (a, b) shows a target lesion in the right frontal lobe with size of 12 mm and other multiple lesions with size of less than 5 mm. In the MRI at BOR date (d, e), previous target lesion and other multiple non-measurable enhancing lesions shows unequivocal size increase. Volumetric analysis of all segmented measurable and non-measurable enhancing lesions at baseline and the BOR date is shown in (c) and (f). On the baseline date (c), the total volume was 778.5mm3 and the lesion number 16. On the BOR date (f), the total volume increased by 70.8% to 1329.4mm3, and the measured number of lesions was 21. The patient died about 14 months after the baseline date