Renal protection CT protocol using low-dose and low-concentration iodine contrast medium in at-risk patients of HCC and with chronic kidney disease: a randomized controlled non-inferiority trial

Table 4 Comparison of lesion detection rates between the standard and RPP groups

	Figure of merit (95% CI)			P-value
	Standard group iDose (A)	RPP group 50 keV (B)	RPP group DL-iodine boosting (C)	(A) vs. (B)	(A) vs. (C)
Arterial phase
All FLLs (n = 62)	0.594 (0.468, 0.721)	0.825 (0.713, 0.936)	0.742 (0.574, 0.911)	0.006	0.163
< 20 mm (n = 50)	0.574 (0.438, 0.711)	0.735 (0.569, 0.901)	0.632 (0.506, 0.758)	0.059	0.524
Portal venous phase
All FLLs (n = 62)	0.606 (0.476, 0.735)	0.800 (0.675, 0.925)	0.747 (0.563, 0.931)	0.033	0.216
< 20 mm (n = 50)	0.577 (0.452, 0.702)	0.698 (0.596, 0.800)	0.620 (0.491, 0.749)	0.086	0.624

Note: CI = confidence interval, FLLs = focal liver lesions, RPP = renal protection protocol. Figure of merit was not calculated for FLLs ≥ 20 mm due to the small number of FLLs (n = 12). P-value < 0.017 indicated a significant difference

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