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Table 4 The multivariate analysis for prediction performance of APTw-SI, MTR and ADC values in the short-term treatment outcome for NPC patients after chemoradiotherapy

From: Amide proton transfer (APT) and magnetization transfer (MT) in predicting short-term therapeutic outcome in nasopharyngeal carcinoma after chemoradiotherapy: a feasibility study of three-dimensional chemical exchange saturation transfer (CEST) MRI

Parameters

AUC (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

P value

MTR

0.818(0.665–0.922)

89.29(71.8–97.7)

66.67(34.9–90.1)

<0.001**

APTw-SI: MTRasym

0.521(0.357–0.681)

75.00(42.8–94.5)

46.43(27.5–66.1)

0.839

ADC

0.649(0.482–0.793)

91.67(61.5–99.8)

60.71(40.6–78.5)

0.109

APTw-SI + ADC

0.652(0.485–0.795)

53.57(33.9–72.5)

91.67(61.5–99.8)

0.099

MTR + APTw-SI

0.839(0.689–0.936)

82.14(63.1–93.9)

83.33(51.6–97.9)

<0.001**

MTR + ADC

0.827(0.675–0.928)

82.14(63.1–93.9)

75.00(42.8–94.5)

<0.001**

MTR + APTw-SI + ADC

0.830(0.678–0.930)

85.71(67.3–96.0)

75.00(42.8–94.5)

<0.001**

  1. Note: AUC: area under the ROC curve; 95%CI: 95% Confidence interval; APTw-SI: amide proton transfer weighted signal intensity; MTR: magnetization transfer ratio; MTRasym: the asymmetric magnetization transfer ratio; ADC: apparent diffusion coefficient. *: P<0.05,**: P<0.01.