Fig. 2

FAPI PET outperforming FDG PET in peritoneal lesion detection. A and B Patients with gastric cancer underwent FAPI PET and FDG PET for initial staging (A) and recurrence detection (B). FAPI PET images were superior to FDG PET in visualization of primary tumours and metastases, especially in peritoneal metastases in these images. C Patient with poorly differentiated gastric adenocarcinoma underwent FAPI PET and FDG PET/CT scans for staging. FAPI PET had higher uptake in primary tumour and peritoneal carcinomatosis compared to FDG PET. D Patient with rectal cancer underwent FAPI PET and FDG PET for staging (MIP images in a and h, respectively). Pelvic peritoneal carcinoma lesion was observed in FAPI PET images (blue arrows in b-d) due to intense tracer uptake. Conversely, low FDG uptake caused the small lesion to be difficult to detect (blue arrows in e–g). (Figure D adapted from Lin et al. [53], under a CC BY license. Figure A and B were originally published in JNM. Qin C, Shao F, Gai Y, Liu Q, Ruan W, Liu F, Hu F, Lan X. 68Ga-DOTA-FAPI-04 PET/MR in the Evaluation of Gastric Carcinomas: Comparison with 18F-FDG PET/CT. J Nucl Med. 2022 Jan;63(1):81–88. © SNMMI [45]. Figure C was adapted from the original figure with extraction of only FAPI PET and FDG PET MIP images from the bigger original figure which was published at reference [47] Kuten et al., under a CC BY license, link of the license: https://creativecommons.org/licenses/by/4.0/)