Fig. 1

Superiority of FAPI PET over FDG PET in Gastrointestinal cancers. A Patient with poorly differentiated gastric adenocarcinoma underwent FAPI PET and FDG PET imaging. FAPI PET revealed high uptake in gastric cardia (slender arrow), paraaortic lymph nodes (dashed arrow) and supraclavicular lymph nodes (short arrows) which were negative on FDG PET. FDG PET revealed increased uptake in gastric anastomosis (bent arrow) which was negative on FAPI PET and eventually was confirmed as residual gastritis by biopsy. B Patient with pancreatic cancer underwent FAPI and FDG PET imaging. FAPI outperformed FDG PET in detecting primary tumours and metastatic lesions such as perihepatic lesions and pulmonary lesion which was confirmed as PDAC metastasis. C Patient with colon cancer underwent FAPI and FDG imaging for an initial assessment. The uptake in the primary tumour (black arrows) and metastatic lesions was higher on FAPI PET than that of FDG PET. D In a patient with moderately differentiated hepatocellular carcinoma, FAPI PET revealed a strongly FAPI-avid lesion in the right hepatic lobe with no positive findings on FDG PET. (Figures adapted from A Zhang et al. [43], C Pang et al. [42] and D Wang et al. [49], under a CC BY license. B was originally published in JNM. Röhrich M, Naumann P, Giesel FL, Choyke PL, Staudinger F, Wefers A, Liew DP, Kratochwil C, Rathke H, Liermann J, Herfarth K, Jäger D, Debus J, Haberkorn U, Lang M, Koerber SA. Impact of 68Ga-FAPI PET/CT Imaging on the Therapeutic Management of Primary and Recurrent Pancreatic Ductal Adenocarcinomas. J Nucl Med. 2021;62(6):779–786. © SNMMI [50])