Table 4 The AUC, optimal threshold, sensitivity, specificity, and accuracy for ADC0Hzmean, ADC0Hz5th, ADC0Hz95th, ADC50Hzmean, ADC50Hz5th, ADC50Hz95th, cADCmean, cADC5th, cADC95th, rcADCmean, rcADC5th, and rcADC95th of the enhancing and peritumoral regions to differentiate brain metastases from glioblastomas
From: Differentiating brain metastasis from glioblastoma by time-dependent diffusion MRI
Parameter | AUC (95% CI) | p Value | Threshold value | Sensitivity (%) | Specificity (%) | Accuracy (%) |
|---|---|---|---|---|---|---|
Enhancing region | ||||||
 ADC0Hzmean | 0.527 (0.420–0.632) | 0.71 | 0.800 (× 10–3 mm2/s) | 80.8 | 25.9 | 71.7 |
 ADC0Hz5th | 0.595 (0.487–0.696) | 0.19 | 0.683 (× 10–3 mm2/s) | 70.8 | 55.6 | 66.3 |
 ADC0Hz95th | 0.592 (0.485–0.694) | 0.20 | 1.659 (× 10–3 mm2/s) | 73.8 | 51.9 | 67.4 |
 ADC50Hzmean | 0.544 (0.437–0.649) | 0.53 | 1.350 (× 10–3 mm2/s) | 72.3 | 44.4 | 64.1 |
 ADC50Hz5th | 0.526 (0.419–0.631) | 0.71 | 0.664 (× 10–3 mm2/s) | 96.9 | 18.5 | 73.9 |
 ADC50Hz95th | 0.615 (0.508–0.714) | 0.10 | 1.704 (× 10–3 mm2/s) | 66.2 | 59.3 | 64.1 |
 cADCmean | 0.877 (0.793–0.937) |  < 0.01 | 0.174 (× 10–3 mm2/s) | 89.2 | 81.5 | 87.0 |
 cADC5th | 0.630 (0.523–0.729) | 0.06 | 0.081 (× 10–3 mm2/s) | 67.7 | 59.3 | 65.2 |
 cADC95th | 0.865 (0.778–0.927) |  < 0.01 | 0.278 (× 10–3 mm2/s) | 87.7 | 81.5 | 85.9 |
 rcADCmean | 0.819 (0.724–0.891) |  < 0.01 | 16.8 (%) | 69.2 | 81.5 | 72.8 |
 rcADC5th | 0.652 (0.546–0.749) | 0.02 | 6.65 (%) | 63.1 | 66.7 | 64.1 |
 rcADC95th | 0.796 (0.700–0.873) |  < 0.01 | 30.6 (%) | 84.6 | 66.7 | 79.3 |
Peritumoral region | ||||||
 ADC0Hzmean | 0.566 (0.459–0.669) | 0.30 | 1.156 (× 10–3 mm2/s) | 40.0 | 81.5 | 52.2 |
 ADC0Hz5th | 0.509 (0.402–0.615) | 0.89 | 0.669 (× 10–3 mm2/s) | 18.5 | 96.3 | 41.3 |
 ADC0Hz95th | 0.559 (0.452–0.662) | 0.37 | 1.615 (× 10–3 mm2/s) | 56.9 | 59.3 | 57.6 |
 ADC50Hzmean | 0.558 (0.450–0.661) | 0.38 | 1.242 (× 10–3 mm2/s) | 38.5 | 77.8 | 50.0 |
 ADC50Hz5th | 0.509 (0.403–0.615) | 0.89 | 1.267 (× 10–3 mm2/s) | 95.4 | 14.8 | 71.7 |
 ADC50Hz95th | 0.559 (0.452–0.662) | 0.37 | 1.691 (× 10–3 mm2/s) | 55.4 | 63.0 | 57.6 |
 cADCmean | 0.598 (0.491–0.699) | 0.14 | 0.072 (× 10–3 mm2/s) | 69.2 | 48.1 | 63.0 |
 cADC5th | 0.580 (0.473–0.682) | 0.21 | 0.038 (× 10–3 mm2/s) | 46.2 | 77.8 | 55.4 |
 cADC95th | 0.569 (0.462–0.672) | 0.30 | 0.140 (× 10–3 mm2/s) | 49.2 | 70.4 | 55.4 |
 rcADCmean | 0.507 (0.401–0.613) | 0.91 | 9.0 (%) | 70.8 | 3.7 | 51.1 |
 rcADC5th | 0.568 (0.460–0.671) | 0.29 | 2.6 (%) | 47.7 | 70.4 | 54.3 |
 rcADC95th | 0.506 (0.399–0.612) | 0.92 | 8.7 (%) | 24.6 | 96.3 | 45.7 |