Table 2 Classification results for 11 targets of interest that have p < 0.05 for one or more ROI sets. For both pipelines the cross-validated AUROC and permutation p-values are shown. The Feature group column for the Conventional pipeline details which feature groups are present in the features from the fit to the whole data set. The Feature group column with the Proposed pipeline is the feature group that was selected in the group selection step of the pipeline. The number of features in the final model for each case are shown, and the row in bold for each target is the sub-segmentation that has the highest AUROC for the Proposed pipeline. EvoST  = Evolutionary subtype

Necrosis

whole

0.841

< 0.01

all

9

0.817

< 0.01

all

9

whole/high/low

0.827

< 0.01

all

11

0.815

< 0.01

shape

7

whole/rim/core

0.856

< 0.01

all

11

0.834

< 0.01

all

10

Sarcomatoid change

whole

0.654

0.17

all

9

0.642

0.13

shape|firstorder

4

whole/high/low

0.757

0.044

all

8

0.764

0.026

shape

7

whole/rim/core

0.694

0.077

all

7

0.692

0.076

shape|firstorder

2

Microvascular invasion

whole

0.813

< 0.01

all

7

0.783

0.010

all

7

whole/high/low

0.791

< 0.01

all

10

0.750

0.011

all

11

whole/rim/core

0.812

< 0.01

all

8

0.774

0.010

all

11

Renal vein invasion

whole

0.862

< 0.01

all

8

0.862

< 0.01

shape

3

whole/high/low

0.845

< 0.01

all

7

0.841

< 0.01

shape

8

whole/rim/core

0.848

< 0.01

all

10

0.852

< 0.01

shape

3

Inferior vena cava invasion

whole

0.705

0.035

all

5

0.680

0.048

shape

2

whole/high/low

0.691

0.033

all

8

0.658

0.064

shape

4

whole/rim/core

0.730

0.040

all

7

0.672

0.092

shape

3

Overall stage 12 vs 34

whole

0.915

< 0.01

all

9

0.901

< 0.01

all

10

whole/high/low

0.890

< 0.01

all

15

0.893

< 0.01

shape

7

whole/rim/core

0.904

< 0.01

all

12

0.892

< 0.01

all

12

Branched EvoST

whole

0.720

0.014

all

11

0.736

0.012

firstorder

2

whole/high/low

0.706

0.032

all

10

0.698

0.032

texture

10

whole/rim/core

0.701

0.044

all

7

0.699

0.035

firstorder

4

Linear EvoST

whole

0.655

0.14

all

8

0.809

0.030

MeshVolume

1

whole/high/low

0.673

0.19

all

3

0.822

0.031

MeshVolume

1

whole/rim/core

0.632

0.19

all

5

0.814

0.015

MeshVolume

1

ITH Index

whole

0.734

0.012

all

6

0.745

0.013

shape

2

whole/high/low

0.755

0.022

all

14

0.728

0.015

all

13

whole/rim/core

0.729

0.015

all

8

0.730

0.014

shape|firstorder

4

wGII Max

whole

0.718

0.012

all

3

0.737

0.015

shape

2

whole/high/low

0.696

0.018

all

3

0.704

0.019

shape

5

whole/rim/core

0.677

0.019

all

3

0.721

0.014

shape

2

Loss 9p21.3

whole

0.793

< 0.01

all

5

0.814

< 0.01

shape

2

whole/high/low

0.779

< 0.01

all

9

0.788

< 0.01

shape

5

whole/rim/core

0.764

0.010

all

7

0.787

0.011

shape

2