Skip to main content

Table 1 List of classification targets and abbreviations, and the proportion in the positive class. Targets with a indicate continuous variables that were binarized by thresholding on the median cohort value – note that the % positive is expected to be 50%, but the presence of repeated values in these targets means this is not exact. Overall stage was binarized as stage 1 or 2 vs stage 3 or 4. The eleven targets in bold font have their predictive models explored in detail in the Results section and Discussion

From: Interpretability of radiomics models is improved when using feature group selection strategies for predicting molecular and clinical targets in clear-cell renal cell carcinoma: insights from the TRACERx Renal study

Target type

Target

# negative

# positive

% positive

Histopathology

Necrosis

41

50

55

Sarcomatoid changes

82

9

10

Microvascular invasion

53

38

42

Renal vein invasion

47

44

48

Inferior vena cava invasion

76

15

16

Overall Stage 12 vs 34

60

31

34

Evolutionary subtype

Branched

68

23

25

Linear

82

9

10

Punctuated

66

25

27

ITH and chromosome complexity

ITH Indexa

49

42

46

wGII Maxa

45

46

51

wGII Mediana

44

47

52

Somatic events

Loss 9p21.3

36

55

60

Loss 9p21.3 isClonal

73

18

20

Loss 14q31.1

32

59

65

Loss 14q31.1 isClonal

68

23

25

BAP1

72

19

21

BAP1 isClonal

80

11

12

PBRM1

41

50

55

PBRM1 isClonal

54

37

41