Fig. 4

One pMMR CRC case (a-f). Male patient, 65 years old. The CEA status was negative. Postoperative pathologic results showed moderately differentiated adenocarcinoma in the left-hemi colon at stage pT4N1M0, with two lymph nodes metastasis. a In unenhanced CT images, the tumour appeared as an isoattenuation thickened bowel wall (green arrow). b In the venous phase, the tumour as a whole appeared as homogeneous hyperenhancement without hypoattenuation-within-tumour (green arrow). c In venous phase MPR images, there was an enhanced lymph node in the local region, with short diameter of 7 mm and long diameter of 8 mm. Only one lymph node had long diameter ≥ 8 mm. d After HE staining, the tumour specimen was assessed as moderately differentiated adenocarcinoma. e, f The pictures show the prediction results of the preoperative model and postoperative model. One dMMR CRC case (g-l). Male patient, 49 years old. The CEA status was negative. Postoperative pathologic results showed mucinous adenocarcinoma in the right-hemi colon at stage pT4N0M1, with peritoneal metastasis and no lymph node metastasis. g In unenhanced CT images, the majority of the tumour appeared as hypoattenuation with 25HU (green arrow). h In the venous phase, the tumour as a whole appeared as inhomogeneous enhancement with no enhancement with 29HU in hypoattenuation-within-tumour (green arrow). i In venous phase MPR images, there was an enhanced lymph node in the local region, with short diameter of 8 mm and long diameter of 8 mm. Three lymph nodes had long diameter ≥ 8 mm. j The tumour specimens were analysed by HE staining. The tumour cell clusters (red arrow) appeared to float in mucinous pools (yellow arrow). k, l The pictures show the prediction results of the preoperative model and postoperative model