Table 4 CTCAE grade 3 and 4 hematologic and hepatic toxicity after PHP in groupPRO (n=192), groupREDPRO (n=21) and groupNOPRO (n=43)
From: Heparin reversal with protamine sulfate after Percutaneous Hepatic Perfusion (PHP): is less more?
Adverse event | CTCAE Grade 3-4 | |
|---|---|---|
Value | % | |
GroupPRO | ||
Hematological toxicity | ||
- Thrombopenia | 74 | 39 |
- Leucopenia | 27 | 14 |
- Anemia | 40 | 21 |
Hepatologic toxicity | ||
- AST increase | 27 | 14 |
- ALT increase | 19 | 10 |
- Hypoalbuminemia | 6 | 3 |
- Hyperbilirubinemia | 7 | 4 |
GroupREDPRO | ||
Hematological toxicity | ||
- Thrombopenia | 3 | 14 |
- Leucopenia | 2 | 10 |
- Anemia | 3 | 14 |
Hepatologic toxicity | ||
- AST increase | 2 | 10 |
- ALT increase | 1 | 5 |
- Hypoalbuminemia | - | - |
- Hyperbilirubinemia | 1 | 5 |
GroupNOPRO | ||
Hematological Toxicity | ||
- Thrombopenia | 10 | 23 |
- Leucopenia | 4 | 9 |
- Anemia | 8 | 19 |
Hepatologic Toxicity | ||
- AST increase | 6 | 14 |
- ALT increase | 1 | 2 |
- Hypoalbuminemia | 4 | 9 |
- Hyperbilirubinemia | 1 | 2 |