From: Heparin reversal with protamine sulfate after Percutaneous Hepatic Perfusion (PHP): is less more?
Parameter | GroupPRO (n=92 patients) | GroupREDPRO (n= 13 patients) | GroupNOPRO (n= 28 patients) | |||
---|---|---|---|---|---|---|
Female; n; % | 48 | 52% | 6 | 46% | 15 | 54% |
Male; n; % | 44 | 48% | 7 | 54% | 13 | 46% |
Age (years); median; interquartile range | 59 | 52-66 | 58 | 51-66 | 58 | 50-63 |
Malignancy; n; % | ||||||
 • Uveal melanoma | 57 | 62% | 13 | 100% | 14 | 46% |
 • Biliary tract cancer | 17 | 19% | - | - | 5 | 17% |
 • Hepatocellular carcinoma | 6 | 7% | - | - | 1 | 4% |
 • Mammary carcinoma | 1 | 1% | - | - | 5 | 17% |
 • Colorectal carcinoma | 3 | 3% | - | - | 1 | 4% |
 • NET carcinoma | 2 | 1% | - | - | 1 | 4% |
 • Pancreatic carcinoma | 2 | 2% | - | - | - | - |
 • Periampullary carcinoma | 3 | 3% | - | - | - | - |
 • Endometrial carcinoma | 1 | 1% | - | - | - | - |
 • Soft tissue sarcoma | - | - | - | - | 1 | 4% |
Comorbidities; n; % | ||||||
 • Hypertension | 32 | 35% | 3 | 23% | 15 | 54% |
 • Diabetes mellitus | 8 | 9% | 3 | 23% | 5 | 18% |
 • Thyroid disorder | 13 | 14% | 6 | 46% | 3 | 11% |
 • Rhythm disorder | 3 | 2% | 2 | 15% | 2 | 4% |
 • Secondary malignoma | 2 | 2% | - | - | - | - |
No. of PHP per patient; median; min-max | 2 | 1-8 | 2 | 1-4 | 2 | 1-8 |
Treatments prior to PHP; n; % | ||||||
 • Liver resection | 14 | 15% | 3 | 23% | 5 | 18% |
 • Systemic chemotherapy | 24 | 26% | 1 | 8% | 11 | 39% |
 • Surgery and systemic chemotherapy | 6 | 7% | - | - | 3 | 11% |
 • Immunotherapy | 10 | 11% | 2 | 15% | 6 | 21% |
 • locoregional/intraarterial liver therapy other than PHP | 16 | 18% | 3 | 23% | 6 | 21% |
 • No previous (liver directed) treatments | 24 | 26% | 4 | 31% | 7 | 25% |