Table 2 Univariate and multivariate analysis results for overall survival and event-free survival; CT group

Clinicopathological features

 Sex (female)

0.777(0.538–1.124)

0.180

0.881(0.624–1.244)

0.473

 Age(> 60)

1.084(0.755–1.557)

0.662

0.872(0.62–1.226)

0.430

 CEA

2.155(1.491–3.114)

 < 0.001

1.761(1.160–2.674)

0.008

1.691(1.192–2.399)

0.003

1.252(0.841–1.863)

0.268

 CA199

1.634(1.121–2.383)

0.011

1.078(0.697–1.668)

0.735

1.691(1.188–2.407)

0.004

0.825(0.558–1.220)

0.335

 Tumor necrosis

1.721(1.100–2.693)

0.017

1.741(1.083–2.798)

0.022

1.769(1.154–2.712)

0.009

1.598(1.013–2.522)

0.044

Imaging features

 Size (> 5 cm)

2.715(1.485–3.186)

 < 0.001

1.152(0.746–1.777)

0.524

2.488(1.738–3.563)

 < 0.001

1.457(0.980–2.166)

0.063

 Tumour multiplicity

2.432(1.615–3.660)

 < 0.001

2.213(1.385–3.537)

0.001

2.190(1.480–3.241)

 < 0.001

1.591(1.040–2.435)

0.032

 Lesion contour (infiltrative)

3.096(2.099–4.565)

 < 0.001

2.565(1.633–4.029)

 < 0.001

2.745(1.915–3.935)

 < 0.001

2.252(1.478–3.432)

 < 0.001

 Tumor location (perihilar)

1.150(0.748–1.768)

0.526

0.985(0.652–1.487)

0.943

 Cirrhosis

0.709(0.410–1.224)

0.217

0.700(0.415–1.180)

0.181

 Vascular invasion

1.775(1.223–2.576)

0.003

1.016(0.653–1.580)

0.945

1.387(0.977–1.969)

0.068

 Lymph node metastasis

3.274(2.212–4.845)

 < 0.001

2.975(1.903–4.650)

 < 0.001

2.566(1.792–3.676)

 < 0.001

1.691(1.129–2.531)

0.011

 Bile duct invasion

1.576(1.089–2.282)

0.016

1.186(0.757–1.860)

0.457

1.217(0.863–1.715)

0.262

 Arterial enhancement pattern

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 Hypoenhancement(vs. hyper)

7.776(4.072–14.847)

 < 0.001

5.318(2.564–11.027)

 < 0.001

7.018(3.824–12.879)

 < 0.001

4.274(2.214–8.251)

 < 0.001

 Rim-enhancement(vs. hyper)

3.820(2.006–7.247)

 < 0.001

2.926(1.459–5.866)

0.002

5.010(2.752–9.123)

 < 0.001

3.521(1.848–6.708)

 < 0.001

 Enhancing capsule

0.627(0.420–0.936)

0.022

1.806(1.005–3.039)

0.025

0.631(0.435–0.917)

0.016

1.213(0.755–1.948)

0.425

 Delayed enhancement

0.658(0.424–1.021)

0.062

1.021(0.691–1.508)

0.919