Table 3 Univariate and multivariate analysis of prognostic factors associated with overall survival
Prognostic Factors | Reference | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | ||
Age, > 60 years | ≤ 60 years | 0.94 (0.78–1.14) | 0.529 | ||
Sex, female | male | 1.16 (0.93–1.44) | 0.184 | ||
Alcohol consumption, yes | No | 0.83 (0.64–1.08) | 0.169 | ||
Hepatitis B carrier, positive | Negative | 1.09 (0.90–1.32) | 0.386 | ||
Hepatitis C carrier, positive | Negative | 1.06 (0.84–1.34) | 0.634 | ||
Diabetes mellitus, yes | No | 1.14 (0.90–1.45) | 0.279 | ||
Size of the largest lesion, > 7 cm | ≤ 7 cm | 1.49 (1.23–1.81) | < 0.001 | ||
Tumor number, > 5 | ≤ 5 | 1.60 (1.25–2.05) | < 0.001 | ||
Serum AFP level, > 200 ng/mL | ≤ 200 ng/mL | 1.56 (1.28–1.90) | < 0.001 | ||
Ascites, present | absent | 1.34 (0.98–1.84) | 0.071 | ||
Alanine transaminase, > 40 U/l | ≤ 40 U/L | 1.17 (0.97–1.42) | 0.101 | ||
Albumin, < 3.6 g/dL | ≥ 3.6 g/dL | 1.61 (1.31–1.98) | < 0.001 | ||
Total bilirubin, > 1.2 mg/dL | ≤ 1.2 mg/dL | 1.41 (1.15–1.73) | < 0.001 | ||
Platelet count, ≤ 103 mm3 | > 103 mm3 | 1.03 (0.84,1.25) | 0.797 | ||
Child–Pugh class B | class A | 1.48 (1.22–1.81) | < 0.001 | 1.52 (1.23–1.87) | < 0.001 |
Treatment response to TACE, SD + PD | CR + PR | 1.91 (1.58–2.32) | < 0.001 | 1.65 (1.35–2.01) | < 0.001 |
ALBI-TAE model | A (Low risk) | ||||
B (Intermediate risk) | 2.08 (1.40–3.09) | < 0.001 | 1.59 (1.06–2.40) | 0.026 | |
C (High risk) | 3.46 (2.30–5.21) | < 0.001 | 2.54 (1.66–3.88) | < 0.001 | |
D (Very high risk) | 5.10 (3.22–8.09) | < 0.001 | 3.73 (2.31–6.01) | < 0.001 | |