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Table 3 Stephenson nomogram criteria as predictors of therapeutic change after molecular imaging based on the whole study cohort. Salvage radiotherapy (sRT); Androgen deprivation therapy (ADT).

From: Influence of molecular imaging on patient selection for treatment intensification prior to salvage radiation therapy for prostate cancer: a post hoc analysis of the PROPS trial

 

Therapeutic decision

n

Mean

SD

95% CI

Odds Ratio

(95% CI)

P-value1

Pre-sRT PSA

sRT

ADT ± sRT

71

19

0.39

0.63

0.49

0.50

(0.28; 0.51)

(0.39; 0.87)

2.63(0.92;7.50)

0.0699T

Surgical Gleason score

sRT

ADT ± sRT

71

20

7.42

7.50

0.71

0.89

(7.25; 7.59)

(7.08; 7.92)

1.15(0.60;2.19)

0.6814

  

Therapeutic decision

  
  

sRT

ADT ± sRT

  
  

n/N

%

n/N

%

Odds Ratio

(95% CI)

P-value 1

Extraprostatic extention

No

Yes

28/71

43/71

39.4

60.6

6/20

14/20

30.0

70.0

1.52(0.52;4.42)

0.4429

Surgical margins

Negatives

Positives

51/71

20/71

71.8

28.2

13/20

7/20

65.0

35.0

1.37(0.48;3.94)

0.5556

Seminal vesicle invasion

No

Yes

55/71

16/71

77.5

22.5

14/20

6/20

70.0

30.0

0.68(0.22;2.05)

0.4924

  1. 1Based on Bivariate Logistic Regression with Wald confidence interval, and Firth Correction for bias (C)
  2. when appropriate. T < 0.15