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Table 4 Comparison of therapeutic response evaluation between CT and PET criteria

From: Comparative analysis of different response criteria at early phase after PD-1 blockade in non-small lung cancer

Variables

RECIST 1.0

irRECIST

Controlled

Uncontrolled

Total

(κ)

Controlled

Uncontrolled

Total

(κ)

PERCIST

 SULpeak

  Controlled

39

9

48

(κ = 0.11)

42

6

48

(κ = 0.18)

  Uncontrolled

4

2

6

4

2

6

  Total

43

11

54

46

8

54

 MTV

  Controlled

26

0

26

(κ = 0.38)

26

0

26

(κ = 0.28)

  Uncontrolled

17

11

18

20

8

28

  Total

43

11

54

46

8

54

 TLG

  Controlled

28

1

29

(κ = 0.38)

29

0

29

(κ = 0.33)

  Uncontrolled

15

10

25

17

8

25

  Total

43

11

54

46

8

54

iPERCIST

 SULpeak

  Controlled

41

9

50

(κ = 0.18)

44

7

51

(κ = 0.11)

  Uncontrolled

2

2

4

2

1

3

  Total

43

11

54

46

8

54

 MTV

  Controlled

32

10

42

(κ = 0)

32

0

32

(κ = 0.40)

  Uncontrolled

11

1

12

14

8

22

  Total

43

11

54

46

8

54

 TLG

  Controlled

34

1

35

(κ = 0.55)

35

0

35

(κ = 0.48)

  Uncontrolled

9

10

19

11

8

19

  Total

43

11

54

46

8

54

EORTC criteria

 SULpeak

  Controlled

35

9

44

(κ = 0)

38

6

44

(κ = 0.06)

  Uncontrolled

8

2

10

8

2

10

  Total

43

11

54

46

8

54

 MTV

  Controlled

27

1

28

(κ = 0.35)

27

0

27

(κ = 0.29)

  Uncontrolled

16

10

26

19

8

27

  Total

43

11

54

46

8

54

 TLG

  Controlled

31

3

34

(κ = 0.34)

31

3

34

(κ = 0.18)

  Uncontrolled

12

8

20

15

5

20

  Total

43

11

54

46

8

54

  1. Abbreviations: CT Computed tomography, PET Positron emission tomography, RECIST Response Evaluation Criteria Solid in Tumors, irRECIST Immune modified Response Evaluation Criteria Solid in Tumors, PERCIST PET Evaluation Criteria in Solid Tumors, iPERCIST Immune modified Response Evaluation Criteria Solid in Tumors, EORTC European Organization for Research and Treatment of Cancer, SULpeak The peak standardized uptake value normalized by lean body mass, MTV Metabolic tumor volume, TLG Total lesion glycolysis, (κ) The value of agreement between two assessments using Cohen κ coefficient
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Cancer Imaging

ISSN: 1470-7330

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