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Fig. 3 | Cancer Imaging

Fig. 3

From: Evaluation of integrin αvβ3-targeted imaging for predicting disease progression in patients with high-risk differentiated thyroid cancer (using 99mTc-3PRGD2)

Fig. 3

99mTc-3PRGD2 SPECT/CT detected local recurrence in a 67-year-old male PTC patient with initial TSH-stimulated Tg 211.5 ng/ml. 99mTc-3PRGD2 SPECT/CT before RAI showed a focal uptake in the left thyroid bed in planar image (A) and transaxial fused SPECT/CT (B), which was seen a soft-tissue mass on CT image. 131I post therapy WBS found a slight radioiodine uptake in planar image (D) and transaxial fused SPECT/CT (E) in the right thyroid bed. The lesion in the left thyroid bed was negative on 131I WBS (F). 99mTc-3PRGD2 SPECT/CT showed no 99mTc-3PRGD2 uptake in the right thyroid bed (C). Four months after initial RAI, the serum TSH-stimulated Tg of the patient elevated to 734 ng/ml. The neck ultrasound examination also detected local recurrence in the left thyroid bed. The patient received another RAI, and the post-therapeutic WBS showed only a vague uptake of radioiodine in the right thyroid bed (G, H). The lesion in the left thyroid bed was still negative on secondary 131I WBS (I)

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Cancer Imaging

ISSN: 1470-7330

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