Table 1 Characteristics of patients by the presence of pECE in prostatectomy specimen (sample size = 169)
From: Early biomarkers of extracapsular extension of prostate cancer using MRI-derived semantic features
Variables | pECE+ | pECE- | p-value |
|---|---|---|---|
(n.° of patients = 44) | (n.° of patients = 125) | ||
Group characteristics | |||
Age at MRI (years) | 60.7 ± 7.2 (45.7; 72.4) | 61.9 ± 6.7 (41.2; 75.8) | 0.334 |
Prostate volume (g) | 38.8 ± 21.2 (20; 148) | 42.8 ± 19.7 (18; 122) | 0.282 |
PSA (ng/ml) | 8.0 ± 4.6 (2.2; 21.2) | 7.0 ± 3.9 (2.2; 31.0) | 0.212 |
PSAD* (ng/ml/g) | 0.2 ± 0.2 (0.1; 1.0) | 0.2 ± 0.1 (0.0; 0.8) | 0.090 |
Index lesion PI-RADS V2 | |||
3 | 1 (2.27) | 9 (7.20) | |
4 | 14 (31.82) | 77 (61.60) | 0.000 |
5 | 29 (65.91) | 39 (31.20) | |
Gleason score in prostate biopsy | |||
Less Aggressive <= 7 (3 + 4) | 14 (31.82) | 106 (84.80) | 0.000 |
More Aggressive > = 7 (4 + 3) | 30 (68.18) | 19 (15.20) | |
Semantic features on MRI | |||
Smooth capsular bulging | |||
No | 5 (11.36) | 61 (48.80) | 0.000 |
Yes | 39 (88.64) | 64 (51.20) | |
Capsular disruption | |||
No | 6 (13.64) | 81 (64.80) | 0.000 |
Yes | 38 (86.36) | 44 (35.20) | |
Unsharp margin | |||
No | 8 (18.18) | 72 (57.60) | 0.000 |
Yes | 36 (81.82) | 53 (42.40) | |
Irregular contour | |||
No | 9 (20.45) | 90 (72.00%) | 0.000 |
Yes | 35 (79.45) | 35 (28.00%) | |
Black striation periprostatic fat | |||
No | 24 (54.55) | 111 (88.80) | 0.000 |
Yes | 20 (45.45) | 14 (11.20) | |
Measurable ECE on MRI | |||
No | 24 (54.55) | 123 (98.40) | 0.000 |
Yes | 20 (45.45) | 2 (1.60) | |
Retoprostatic angle obliteration | |||
No | 35 (79.55) | 125 (100.00) | — |
Yes | 9 (20.45) | 0 (0.00) | |
Proposed variables on MRI | |||
Index lesion length (mm) | 17.6 ± 6.0 (7.0; 30.0) | 12.8 ± 4.9 (5.0; 32.0) | 0.000 |
Tumor capsular contact length (mm) | 19.9 ± 8.8 (0.0; 40.0) | 9.8 ± 6.5 (0.0; 26.0) | 0.000 |