Fig. 1

Semi-quantitative parameters were computed from the DCE MRI time series of each patient by fitting a piece-wise linear function to the signal intensity of each voxel, and AUC extracted from the normalised signal intensity curve. Quantitative maps Ktrans and Ve were computed by fitting the Tofts pharmacokinetic model to the DCE MRI data and the iAUGC60 parameter from the area under the Gadolinium contrast agent concentration curve