Table 4 Univariate and multivariate Cox regression analysis for OS in 144 patients excluding CR response

Age > 55 (years)

0.67 (0.44, 1.02)

0.063

0.95 (0.60, 1.50)

0.819

0.97 (0.61, 1.53)

0.881

Male

0.94 (0.52, 1.70)

0.843

1.44 (0.76, 2.73)

0.264

1.26 (0.67, 2.39)

0.470

Child–Pugh B class

1.09 (0.64, 1.86)

0.743

1.23 (0.69, 2.17)

0.480

1.43 (0.80, 2.57)

0.232

AFP > 400 (ng/ml)

2.09 (1.37, 3.19)

0.001

1.34 (0.84, 2.15)

0.222

1.47 (0.91, 2.37)

0.114

Multifocal disease

2.22 (1.43, 3.45)

<  0.001

1.25 (0.74, 2.09)

0.406

1.28 (0.77, 2.14)

0.348

Lesion diameter (cm)

1.18 (1.12, 1.25)

<  0.001

1.14 (1.07, 1.22)

<  0.001

1.14 (1.07, 1.22)

<  0.001

Macrovascular invasion

3.53 (2.28, 5.45)

<  0.001

2.79 (1.68, 4.63)

<  0.001

2.71 (1.62, 4.53)

<  0.001

Repeated treatment courses

0.70 (0.52, 0.93)

0.013

0.49 (0.35, 0.70)

<  0.001

0.53 (0.38, 0.75)

<  0.001

AEF_post > 54.85%

2.47 (1.61, 3.78)

<  0.001

1.82 (1.13, 2.92)

0.014

–

–

Decrease ratio > −0.102

0.32 (0.20, 0.53)

<  0.001

–

–

0.61 (0.35, 1.04)

0.068