Reliability of dynamic susceptibility contrast perfusion metrics in pre- and post-treatment glioma

Cancer Imaging

Table 3 Inter-observer classification for perfusion parameters of differently shaped regions of interest and in different areas in glioma patients prior to treatment

	Perfusion metric	Intraclass Correlation	95%-Confidence interval		P-value
	Perfusion metric	Intraclass Correlation	Lower Bound	Upper Bound	P-value
Whole tumor region; Untreated group of patients; Circular ROI	CBF	0.963	0.924	0.984	< 0.001
	CBV	0.948	0.892	0.977	< 0.001
	TTP	0.951	0.899	0.979	< 0.001
Tumor hotspot; Untreated group of patients; Circular ROI	CBF	0.441	-0.156	0.756	0.058
	CBV	0.501	-0.032	0.782	0.030
	TTP	0.198	-0.658	0.649	0.269
Peritumoral region; Untreated group of patients; Circular ROI	CBF	0.821	0.630	0.922	< 0.001
	CBV	0.924	0.843	0.967	< 0.001
	TTP	0.741	0.465	0.887	< 0.001
Whole tumor region; Untreated group of patients;Polygonal ROI	CBF	0.504	-0.026	0.783	0.029
	CBV	0.687	0.352	0.863	0.001
	TTP	0.856	0.703	0.937	< 0.001
Tumor hotspot; Untreated group of patients; Polygonal ROI	CBF	0.828	0.644	0.925	< 0.001
	CBV	0.529	0.027	0.794	0.021
	TTP	0.200	-0.655	0.650	0.268
Peritumoral region; Untreated group of patients; Polygonal ROI	CBF	0.442	-0.154	0.756	0.057
	CBV	0.409	-0.223	0.742	0.078
	TTP	0.113	-0.834	0.612	0.363

CBV Cerebral blood volume, ICC Intraclass correlation coefficient, CBF Cerebral blood flow, TTP Time-to-peak

ISSN: 1470-7330