Fig. 3

a-d- A 65 y/o female, presented with macroscopic hematuria. c. T2-weigthed image in axial plane showing a flat lesion (*) in the right posterior bladder wall, protruding through the muscle layer. b. In ADC map, the lesion is seen extending across the whole wall, with interruption of low signal of muscularis propria; c. Arterial phase, after intravenous contrast media injection, showing enhancement of the lesion (arrowhead), underneath the lamina propria (white arrow), confirming the muscular involvement. d. In this Hematoxilin- Eosin (H&E, 100x), the lesion (L) is infiltrating the muscularis propria of the bladder (asterisk). A high-grade urothelial cancer invading the muscular (T2 staging) was confirmed after cystectomy