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Table 2 Parameter values and P values derived with the ET and DP models

From: Endometrial carcinoma: use of tracer kinetic modeling of dynamic contrast-enhanced MRI for preoperative risk assessment

  Low-risk type
Median (95% CI)
High-risk type
Median (95% CI)
P value Corrected P value
ET model
 Ktrans 0.10 (0.09–0.12) 0.05 (0.04–0.05) < 0.001 < 0.001*
 Vp 1.02 (0.82–1.14) 0.58 (0.38–0.74) < 0.001 < 0.001*
 Ve 8.12 (6.50–10.23) 7.86 (6.95–8.96) 0.39 0.39
 Kep 1.20 (0.94–1.44) 0.57 (0.51–0.68) < 0.001 < 0.001*
DP model
 F 13.01 (12.26–14.79) 8.12 (6.86–8.74) < 0.001 < 0.001*
 MTT 15.15 (12.12–17.33) 12.38 (11.03–14.19) 0.08 0.13
 Vp 3.03 (2.37–3.69) 1.46 (1.22–2.02) < 0.001 < 0.001*
 Ve 6.17 (4.88–8.06) 6.31 (5.74–8.09) 0.61 0.61
 PS 8.32 (6.75–10.74) 4.01 (3.16–5.14) < 0.001 < 0.001*
 E 43.63 (37.02–51.29) 38.72 (34.42–47.26) 0.52 0.63
  1. * Significant P values
  2. ET extended Tofts, DP distributed parameter, Ktrans transfer constant, Kep efflux rate constant, Vp blood volume, Ve extravascular extracellular volume, F blood flow, MTT mean transit time, PS permeability surface area product, E extraction fraction. Ktrans and Kep are in units of min−1, Vp and Ve are in units of mL/100 mL, F and PS are in units of mL/min/100 mL, MTT is in unit of seconds, E is in unit of %