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Table 1 Baseline and MSCT Characteristics of Patients with PDAC

From: Radiomics nomogram for the preoperative prediction of lymph node metastasis in pancreatic ductal adenocarcinoma

Characteristics Training cohort Validation cohort
LN-negative
(n = 81)
LN-positive
(n = 99)
P value LN-negative
(n = 26)
LN-positive
(n = 19)
P value
Age (y, mean ± SD) 61.7 ± 7.2 59.6 ± 9.8 0.115 62.9 ± 8.1 64.1 ± 7.3 0.620
BMI (kg/m2, mean ± SD) 22.6 ± 2.8 22.6 ± 2.6 0.999 23.17 ± 3.0 22.5 ± 2.4 0.422
Sex
 Male 47 (58.0) 60 (60.6) 0.726 16 (61.5) 14 (73.7) 0.393
 Female 34 (42.0) 39 (39.4) 10 (38.5) 5 (26.3)
 CA19–9 (μg/L, median, min-max) 332.1 (71.6–1066.6) 293.5 (103.7–1200.0) 0.479 278.4 (13.6–1200.0) 305.5 (41.8–1200.0) 0.926
CA 19–9
  < 1000 μg/L 57 (70.4) 65 (65.7) 0.501 17 (65.4) 13 (68.4) 0.831
 ≥1000 μg/L 24 (29.6) 34 (34.3) 9 (34.6) 6 (31.6)
T stage
 T1 14 (17.3) 8 (8.1) 0.158 5 (19.2) 0 0.157
 T2 15 (18.5) 23 (23.2) 5 (19.2) 5 (26.3)
 T3–4 52 (64.2) 68 (68.7) 16 (61.5) 14 (73.7)
M stage
 M0 80 (98.8) 91 (91.9) 0.043 23 (88.5) 19 (100.0) 0.068
 M1 1 (1.23) 8 (8.1) 0 3 (11.5)
Differentiation grade
 Well to moderately 65 (80.3) 85 (85.9) 0.315 23 (88.5) 12 (63.2) 0.070
 Poorly to undifferentiated 16 (19.8) 14 (14.14) 3 (11.5) 7 (36.8)
Surgery
 Pylorus-preserving pancreatoduodenectomy 2 (2.47) 10 (10.1) 0.133 2 (7.7) 2 (10.5) 0.781
 Pancreatoduodenectomy 43 (53.1) 53 (53.5) 14 (53.9) 9 (47.4)
 Total pancreatectomy 7 (8.6) 4 (4.0) 1 (3.9) 0
 Distal pancreatectomy 29 (35.8) 32 (32.3) 9 (34.6) 8 (42.1)
Location
 Head 44 (54.3) 63 (63.6) 0.205 16 (61.5) 11 (57.9) 0.805
 Neck, body and tail 37 (45.7) 36 (36.4) 10 (38.5) 8 (42.1)
 Size (mm, median, interquartile range) 26.0 (19.8–31.2) 23.5 (19.0–31.8) 0.885 24.4 (16.7–28.9) 29.2 (21.3–35.3) 0.044
Vascular invasion
 No 50 (61.7) 60 (60.6) 0.878 19 (73.1) 11 (57.9) 0.286
 Yes 31 (38.3) 39 (39.4) 7 (26.9) 8 (42.1)
Organ invasion
 No 72 (88.9) 86 (86.9) 0.681 22 (84.6) 15 (78.0) 0.704
 Yes 9 (11.1) 13 (13.1) 4 (15.4) 4 (21.1)
CT-reported LN status
 Negative 61 (75.3) 57 (57.6) 0.013 19 (73.1) 9 (47.4) 0.079
 Positive 20 (24.7) 42 (42.4) 7 (26.9) 10 (52.6)
  1. Data are presented as n (%)
  2. MSCT multislice computed tomography, LN lymph node, CA19–9 carbohydrate antigen 19–9