Fig. 3

Serial MIP images (A) in a patient with widespread metastatic melanoma demonstrate resolution of an in-transit deposit on the lateral aspect of the left leg (arrow on baseline scan) and gradual regression of metastatic disease over time despite residual left inguinal nodal abnormality after 6 months of immune checkpoint therapy. On coronal PET and CT images (B), nodular but contiguous linear uptake in the subcutaneous fat along the medial left thigh demonstrates no change over time on the MIP images above and clinically correlated with a varicose vein. Transaxial images (C) are more difficult to interpret than the coronal images in demonstrating mildly ¹⁸F-FDG -avid nodularity and a rounded shape on correlative CT, emphasizing the importance of review of images in orthogonal planes