Fig. 2

89-year-old woman with previous localization of melanoma on the right lower limb, who was on active surveillance. A: zoomed MIP images; B: transverse PET slices and C corresponding CT slices. Subcutaneous ¹⁸F-FDG foci related to in-transit metastases can be seen on the right leg (red arrows). Also visible are foci related to venous varicosity, not to be mistaken for subcutaneous metastases (orange arrow). It is noteworthy that in-transit metastases are only clearly visible on digital images reconstructed with small-voxels. EARL-compliant images, which mimic former generation PET systems by applying a post-reconstruction filtering step [23], are equivocal. EARL: European Association of Nuclear Medicine Research limited