Fig. 3
From: Integrin αvβ6-targeted MR molecular imaging of breast cancer in a xenograft mouse model
Cytological verification of targeting ability of cFK-9-USPIO nanoparticles using MRI. The harvested 4 T1 and HEK293 cells were incubated with medium containing cFK-9-USPIO or cFK-9-USPIO with excess cFK-9 peptides. a MR image shows decreased T2 signal in 4 T1 cell phantoms incubated with cFK-9-USPIO compared to HEK293 cells or control, and higher T2 signal in 4 T1 cell phantoms incubated with cFK-9-USPIO with excess cFK-9 peptides than cFK-9-USPIO only. b Quantitative plots of differences in the reduction of T2 values of 4 T1 cells incubated with cFK-9-USPIO compared to that of 4 T1 cells incubated cFK-9-USPIO with excess cFK-9 peptides. In addition, the reduction of T2 values in 4 T1 incubated with cFK-9-USPIO is higher than HEK293. ***, p < 0.001