Fig. 2
Image examples of a patient with comparatively low tumor vascularity. 64 years old female patient with PDAC of the pancreatic corpus/ tail. a-c) Axial MR images with the patient in supine position. a Axial T2-HASTE MR image shows upstream dilatation of the main pancreatic duct and concomitant parenchymal atrophy (green arrows) due to an obstructing tumor in the pancreatic corpus/ tail (red arrows). b Diffusion-weighted MR image (b = 300 s/mm2) with a VOI encompassing the tumor (VOI tumor). c Diffusion-weighted MR imaging with overlaying color-coded f-map. Mean calculated ftumor-value for both readers was low (8.9%). d–f Axial CT images with the patient in an oblique, 30°, right-sided down position. d Temporal maximum intensity projection (MIP) CT images of the perfusion sequence with VOIs encompassing the pancreas (VOI pancreas) and the tumor (VOI tumor). e-f Temporal MIP CT images with color-coded parameter maps for blood flow (BFtumor, e) and blood volume (BVtumor, f) derived from perfusion-sequence. Mean BFtumor and BVtumor were low (30.9 ml/100 ml/min and 1.8 ml/100 ml). g) Representative cutout of corresponding immunostained tissue slide (CD34) after semi-automated segmentation of microvessels shows low MVDtumor. MVDtumor in total analysis area was 34.1 /mm2