Value of 18F-FDG-PET to predict PD-L1 expression and outcomes of PD-1 inhibition therapy in human cancers

Cancer Imaging

Table 1 Relationship between PD-L1 expression and FDG uptake in review literatures

Authors/References	Sample size	Cancer type	Histology	Correlation between FDG uptake and PD-L1 expression		Correlation of FDG uptake with TILs (statistical assessment)
Authors/References	Sample size	Cancer type	Histology	p-value	PD-L1 clone
Kasahara N / [8]	167	Lung cancer	SCC	0.02	E1L3N	Not significant
Kaira K / [9]	315	Lung cancer	AC	0.01	E1L3N/28–8	Not significant
Takada K / [7]	579	Lung cancer	SCC/AC/other	< 0.001	SP142	NA
Zhang M / [10]	84	Lung cancer	SCC	0.035	28–8	NA
Kasahara N / [24]	98	Lung cancer	SCLC	0.36	E1L3N	Significant
Hu B / [25]	362	Lung cancer	SCC/AC	0.001	28–8	NA
Wang Y / [27]	122	Lung cancer	SCC/AC	0.012	NA	Significant
Jiang H / [26]	65	Colon cancer	AC	0.000	28–8	NA
Chen R / [15]	63	Bladder cancer	UC/SCC/SRC	0.032	NA	NA
Zhao L / [28]	84	NPC	SCC	< 0.001	SP263	NA
Hirakata T / [30]	97	Breast cancer	AC	< 0.001	28–8	Significant

Abbreviations: PD-L1 programmed death ligand-1, ¹⁸F-FDG 2-Deoxy-2-[¹⁸F] fluoro-D-glucose, TILs tumor infiltrative lymphocytes, SCC squamous cell carcinoma, AC adenocarcinoma, SCLC small cell lung cancer, UC urothelial cancer, SRC signet ring cell carcinoma, NPC nasopharyngeal carcinoma, NA not applicable

ISSN: 1470-7330