Fig. 2From: Quantification of tumor burden in multiple myeloma by atlas-based semi-automatic segmentation of WB-DWIAtlas building scheme. Initially, an image is selected as the reference (fixed) and the others are moving images. Each moving image is registered to the fixed image, by applying an optimal rigid transformation, followed by an optimal affine and free-form transformations (B-spline), which maximizes the similarity between the fixed and moving images. Then, the registered moving images are averaged, resulting in a mean image. Then, this mean image is selected as the new fixed image and all the original moving images are again registered to it, following the same process. This was repeated until no meaningful changes were found between successive mean imagesBack to article page