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Table 3 Differences in SWE values and histologic biomarkers according to GLUT1 expression

From: Tumor stiffness measured by shear wave elastography correlates with tumor hypoxia as well as histologic biomarkers in breast cancer

 

GLUT1

*p value

≤median (n = 41)

>median (n = 41)

Eaverage

85. 4 ± 29.3 kPa

125.5 ± 14.8 kPa

< 0.001

Eratio

11.7 ± 5.7

17.9 ± 9.6

< 0.001

Lymph node

  

0.373

 negative

21 (45.7)

25 (54.3)

 

 positive

20 (55.6)

16 (44.4)

 

ER

  

0.001

 negative

5 (21.7)

18 (78.3)

 

 positive

36 (61.0)

23 (39.0)

 

PR

  

0.004

 negative

7 (26.9)

19 (73.1)

 

 positive

34 (60.7)

22 (39.3)

 

HER2

  

0.026

 negative

37 (56.1)

29 (43.9)

 

 positive

4 (25.0)

12 (75.0)

 

Ki67

  

0.001

 negative

28 (68.3)

13 (31.7)

 

 positive

13 (31.7)

28 (68.3)

 

Tumor grade

  

0.005

 1 or 2

33 (61.1)

21 (38.9)

 

 3

8 (28.6)

20 (71.4)

 

Molecular subtype

  

0.001

 luminal A cancer

21 (80.8)

5 (19.2)

 

 luminal B cancer

15 (42.9)

20 (57.1)

 

 HER2-overexpressing cancer

2 (25.0)

6 (75.0)

 

 triple-negative cancer

3 (23.1)

10 (76.9)

 
  1. Data refers to the numbers of subject included, means ± standard deviation for continuous variables and counts (%) for categorical variables
  2. *p values indicate comparisons between two groups using the Mann–Whitney U test or t test and four groups using the Kruskal–Wallis test
  3. GLUT1 glucose transporter-1 protein, ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2