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Table 2 Relationship between SWE values and histologic biomarkers of breast cancers

From: Tumor stiffness measured by shear wave elastography correlates with tumor hypoxia as well as histologic biomarkers in breast cancer

 

Eaverage

*p value

Eratio

*p value

Lymph node

 negative (n = 46)

108.1 (104.4 ± 31.6)

0.695

12.8 (12.8 ± 6.4)

0.027

 positive (n = 36)

115.1 (106.8 ± 29.7)

 

16.2 (17.3 ± 10.1)

 

ER

 negative (n = 23)

126.3 (118.5 ± 29.1)

0.006

15.9 (17.6 ± 11.2)

0.122

 positive (n = 59)

109.0 (100.4 ± 29.9)

 

13.0 (13.7 ± 6.9)

 

PR

 negative (n = 26)

124.8 (117.7 ± 27.9)

0.009

16.2 (17.6 ± 11.3)

0.134

 positive (n = 56)

108.1 (99.8 ± 30.4)

 

13.1 (13.5 ± 6.5)

 

HER2

 negative (n = 66)

111.6 (103.4 ± 31.7)

0.256

13.0 (13.6 ± 6.3)

0.085

 positive (n = 16)

119.7 (114.1 ± 24.6)

 

15.6 (19.7 ± 13.5)

 

Ki67

 negative (n = 41)

102.9 (95.0 ± 32.8)

0.002

12.8 (12.6 ± 5.8)

0.048

 positive (n = 41)

119.2 (116.0 ± 24.5)

 

14.7 (17.0 ± 10.0)

 

Tumor grade

 1 or 2 (n = 54)

104.4 (98.2 ± 30.9)

0.002

12.4 (13.3 ± 8.8)

0.003

 3 (n = 28)

120.9 (119.5 ± 25.2)

 

17.2 (17.6 ± 7.0)

 

Molecular subtype

 luminal A cancer (n = 26)

94.8 (91.4 ± 30.7)

0.009

12.4 (12.1 ± 5.5)

0.094

 luminal B cancer (n = 35)

115.3 (108.2 ± 27.1)

 

14.2 (15.1 ± 7.5)

 

 HER2-overexpressing cancer (n = 8)

127.6 (118.0 ± 32.1)

 

22.4 (24.1 ± 16.5)

 

 triple-negative cancer (n = 13)

123.2 (118.5 ± 30.8)

 

13.2 (13.7 ± 4.9)

 
  1. Data are displayed as median (mean ± standard deviation)
  2. *p values indicate comparisons between two groups using the Mann–Whitney U test or t test and four groups using the Kruskal–Wallis test
  3. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2