Table 5 Cox proportional regression analysis for postoperative recurrence in 54 patients after excluding eight patients who underwent delayed surgery (n = 54)
Univariate: HR (95% CI) | p-value | aMultivariate: HR (95% CI) | p-value | |
|---|---|---|---|---|
Age | 1.028 (0.993,1.063) | 0.117 | AD. | |
Male | 0.822 (0.406,1.666) | 0.587 | AD. | |
Tumor differentiation | AD. | |||
Well | ||||
Moderate | 1.090 (0.367,3.240) | 0.877 | ||
Poor | 1.374 (0.378,4.998) | 0.629 | ||
Interval from initial imaging and operation (mo.) | 0.934 (0.195,4.472) | 0.932 | AD. | |
Charlson co-morbidity index | 1.043 (0.847,1.286) | 0.691 | 0.784 (0.526,1.170) | 0.233 |
Adjuvant chemotherapy | 0.39 (0.185, 0.821) | 0.013* | 0.393 (0.137,1.128) | 0.393 |
Preoperative CA19–9 | 1.09 (0.979,1.213) | 0.115 | 1.127 (0.984,1.291) | 0.085 |
Postoperative CA19–9 | 1.112 (1.018,1.214) | 0.019* | 1.148 (1.025,1.285) | 0.017* |
Radiologic tumor size | 1.097 (0.664,1.812) | 0.719 | 1.409 (0.768, 2.585) | 0.268 |
Resectability | ||||
Resectable | 1 | 1 | ||
Borderline resectable | 1.683 (0.806,3.515) | 0.166 | 2.123 (0.876,5.144) | 0.096 |
Conspicuity score > 2 | 3.173 (1.522,6.613) | 0.002* | 3.944 (1.739, 8.945) | 0.001* |
Pathologic tumor size (cm) | 1.586 (1.026,2.452) | 0.038* | 2.064 (1.265, 3.366) | 0.004* |
Positive resection margin | 1.32 (0.499,3.490) | 0.575 | 1.147 (0.384, 3.427) | 0.806 |
Lymphatic invasion | 2.299 (1.048,5.045) | 0.038* | 2.966 (1.153,7.629) | 0.024* |
Perineural invasion | 2.014 (0.818,4.958) | 0.128 | 3.569 (1.194,10.67) | 0.023* |
Microvascular invasion | 1.135 (0.454, 2.835) | 0.787 | 1.545 (0.531,4.498) | 0.425 |
Pathologic T stage | ||||
T1 | 1 | 1 | ||
T2 | 0.383 (0.079,1.846) | 0.232 | 0.536 (0.062,5.124) | 0.610 |
T3 | 0.600 (0.135,2.663) | 0.502 | 0.918 (0.108,7.816) | 0.937 |
Positive lymph node | 1.157 (0.559, 2.392) | 0.695 | 1.117 (0.47,2.653) | 0.802 |