Table 4 Cox proportional regression analysis for postoperative recurrence (n = 62)
Univariate: HR (95% CI) | p-value | aMultivariate: HR (95% CI) | p-value | |
|---|---|---|---|---|
Age | 1.019 (0.989,1.050) | 0.210 | AD. | |
Male | 0.893 (0.474,1.684) | 0.727 | AD. | |
Tumor differentiation | AD. | |||
Well | ||||
Moderate | 1.031 (0.419,2.535) | 0.948 | ||
Poor | 1.187 (0.393,3.581) | 0.761 | ||
Interval between initial imaging and operation (mo.) | 1.085 (0.990,1.189) | 0.08 | AD. | |
CCI | 1.044 (0.865,1.260) | 0.653 | 0.918 (0.675–1.248) | 0.585 |
Adjuvant chemotherapy | 0.474 (0.242,0.926) | 0.029* | 0.544 (0.220–1.343) | 0.187 |
Preoperative CA19–9 | 1.105 (1.007,1.214) | 0.036* | 1.146 (1.022–1.286) | 0.02* |
Postoperative CA19–9 | 1.105 (1.021,1.196) | 0.014* | 1.114 (1.006–1.232) | 0.037* |
Radiologic tumor size | 1.248 (0.882,1.767) | 0.211 | 1.483 (0.966–2.276) | 0.072 |
Resectability | ||||
Resectable | 1 | 1 | ||
Borderline resectable | 1.560 (0.799,3.049) | 0.193 | 1.868 (0.833–4.188) | 0.129 |
Unresectable | 4.018 (0.896,18.012) | 0.069 | 1.349 (0.093–19.548) | 0.826 |
Conspicuity score > 2 | 3.122 (1.616,6.029) | 0.001* | 3.669 (1.735,7.762) | 0.001* |
Pathologic tumor size (cm) | 1.383 (1.058, 1.807) | 0.018* | 1.612 (1.062–2.448) | 0.025* |
Positive resection margin | 1.528 (0.664,3.514) | 0.318 | 1.407 (0.552–3.583) | 0.475 |
Lymphatic invasion | 2.058 (1.043,4.059) | 0.037* | 2.757 (1.224–6.211) | 0.014* |
Perineural invasion | 1.659 (0.815,3.378) | 0.163 | 2.448 (1.048–5.721) | 0.039 |
Microvascular invasion | 1.318 (0.61,2.848) | 0.482 | 1.464 (0.644–3.327) | 0.363 |
Pathologic T stage | ||||
T1 | 1 | 1 | ||
T2 | 0.417 (0.089,1.947) | 0.266 | 0.583 (0.069–4.928) | 0.620 |
T3 | 0.588 (0.135,2.588) | 0.480 | 0.739 (0.09–6.055) | 0.778 |
T4 | 0.402 (0.035,4.645) | 0.465 | 0.535 (0.022–13.170) | 0.702 |
Positive lymph node | 1.178 (0.615, 2.256) | 0.622 | 1.261 (0.605–2.630) | 0.536 |