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Table 1 overview of the 12 studies reporting WB-MRI in asymptomatic subjects of the general population

From: Whole-body magnetic resonance imaging (WB-MRI) for cancer screening in asymptomatic subjects of the general population: review and recommendations

  

WB-MRI protocol

Per-lesion analysis

Per-subject analysis

Cancer detection

Author

Year

Country

Magnet strenght

T1W TSE

T1W GE

T2W FS

T2W

DWI

Contrast

Cardiovascular sub-protocol

Classification method

All findings

Not relevant

≥ Relevant

Highly relevant

n° of WB-MRI examinations

Entirely normal (no findings)

Abnormal findings reported

With relevant findings (requiring further evaluation)

Suspected malignant cancers

Confirmed malignant cancers

Goehde37

2005

GER

1.5

 

WB

 

S

S

Y

cardiac,

WB-MRA

binary: 1 (non-relevant), 2 (relevant)

329

233

70,8%

96

29,2%

 

298

    

82

31.0%

1

0,3%

1

0.3%

Baumgart38

2007

GER

1.5

 

WB

 

S

 

Y

cardiac,

WB-MRA

–

      

1007

      

4

0,4%

4

0.4%

Lo41

2008

HKG

3.0

 

WB

S

WB

   

binary: 1 (non-relevant), 2 (relevant)

234

210

89,7%

24

10,3%

 

132

8

6,1%

124

93,9%

24

18.2%

4

3,0%

4

3.0%

Takahara42

2008

NED

1.5

 

WB

 

WB

WB

  

–

       

10

    

1

10.0%

1

10,0%

1

10.0%

Hegenscheid43

2013

GER

1.5

 

WB

WB

S

S

optional

cardiac,

WB-MRA

categorical system: 1(non-relevant), 2 (relevant benign), 3 (relevant unclear), 4 (relevant malignant)

13,455

12,403

92,2%

990

7,4%

62

0,5%

2500

    

787

31.5%

62

2,5%

  

Cieszanowski44

2014

PLN

1.5

 

WB

WB

    

categorical system: 1 (non-relevant), 2 (moderately or potentially relevant), 3 (relevant)

3375

2997

88,8%

378

11,2%

15

0,4%

666

7

1,1%

659

98,9%

  

7

1,1%

7

1.1%

Tarnoki45

2015

GER

3.0

WB

WB

WB

 

WB

Y

WB-MRA

categorical system: 1 (non-relevant), 2 (requiring further evaluation), 3 (relevant)

68

44

64,7%

24

35,3%

1

1,5%

22

2

9,1%

20

90,9%

15

68.0%

1

4,5%

  

Ulus46

2016

TUR

1.5

  

WB

WB

S

optional

 

–

      

116

33

28,4%

83

71,6%

12

10.3%

3

2,6%

2

1.7%

Saya47

2017

UK

1.5

 

WB

WB

 

WB

  

categorical system: 1 (definitely benign), 2 (likely to be benign), 3 (equivocal), 4 (likely to be malignant), 5 (definitely malignant)

      

44

    

8

18.2%

0

0,0%

0

0%

Lee48

2018

KOR

1.5

 

WB

WB

    

categorical system: 1 (benign), 2 (requiring further evaluation), 3 (malignant)

500

290

58,0%

210

42,0%

6

1,2%

229

16

7,0%

213

93,0%

  

6

2,6%

2

0.9%

Perkins*39

2018

USA

3.0

 

WB

 

WB

WB

N

cardiac

–

       

209*

    

70

33.5%

4

1,9%

4*

1.9%

Hou40

2020

USA

3.0

 

WB

 

WB

WB

N

cardiac

–

       

1190

        

20

1.7%

Total

 

17,961

16,336

91,0%

1625

9,0%

84

0.5%

6214

66 / 1165

5,7%

1099 / 1165

94,3%

999 / 3331

30,0%

93 / 5233 1.8%

41 / 3692 1.1%

  1. Abbreviations: T1W = T1 weighted; T2W = T2 weighted; TSE = turbo spin echo; GE = gradient echo; FS = fat saturated; DWI = diffusion weighted imaging; S = single anatomic segment; WB = whole-body; WB-MRA = whole-body magnetic resonance angiography
  2. * subjects included in this study are also included in the study by Hou et al. Therefore, they were not counted in the overall number of WB-MRI examinations, nor in the overall number of confirmed malignant cancers
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Cancer Imaging

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