Fig. 11
From: Nonprostatic diseases on PSMA PET imaging: a spectrum of benign and malignant findings
Two different patients with pulmonary histoplasmosis. On top, a 70-year-old patient under staging of prostate cancer (iPSA = 7.0 ng/mL, Gleason 8 = 4 + 4). 68Ga-PSMA-PET MIP (a), axial CT (b), axial PET/CT (c) and CT-guided biopsy (d) images show an irregular pulmonary nodule with faint uptake (arrow). See also the primary tumor on A (arrowhead). On bottom, a 64-year-old patient with biochemical recurrence (PSA = 0.66 ng/mL, Gleason 9 = 4 + 5) 8 years after radical prostatectomy and under androgen deprivation therapy (Abiraterone) for the last 2 years. 68Ga-PSMA-PET MIP (g), axial CT (h) and PET/CT (i) images show a rounded lung nodule in the lower lobe of the right lung without PSMA utpake (arrows). Histology images (e, f, j, k) show a positive Grocott stain, with multiple yeasts (dashed arrow) and areas of focal neutrophils conglomerates, consistent with histoplasmosis