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Fig. 1 | Cancer Imaging

Fig. 1

From: Contrast-enhanced ultrasound findings of adult renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma

Fig. 1

A 68-year-old man with a 2.5-cm diameter Xp11.2/TFE3 RCC. a Conventional US showed a hypoechoic mass with peripheral calcifications in the interpolar region of the right kidney (arrows). b CDFI showed the tumour lack of blood flow signal (arrows). c The tumour enhanced simultaneously with the renal cortex at the initial enhancement of CEUS imaging (arrows). d The tumour showed heterogeneous hypoenhancement at the peak enhancement of CEUS imaging (arrows). e The tumour showed fast wash-out at the medullary phase of CEUS imaging (arrows). f Haematoxylin eosin (HE) staining showed an eosinophilic cytoplasm arranged with a nested architecture (× 200). g Immunohistochemical staining demonstrated diffuse and strong TFE3 protein expression in the tumour cell nucleus (× 200). h FISH showed separated red and green signals in the tumour cell nucleus, which were considered to be the positive signals of TFE3 rearrangement (× 1000)

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Cancer Imaging

ISSN: 1470-7330

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